A5026090669- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- COVID-19 Clinical Research Studies
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Fibroblast Growth Factor Research
- Viral-associated cancers and disorders
- Cancer and Skin Lesions
- Protein Tyrosine Phosphatases
- Colorectal and Anal Carcinomas
- Alcohol Consumption and Health Effects
- Abdominal Trauma and Injuries
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Lipids, and Metabolism
Kurume University
2016-2025
Yale University
2020-2021
Kurume University Hospital
2012-2015
National Hospital Organization Kyushu Cancer Center
2015
Combined hepatocellular-cholangiocarcinoma comprises <1% of all liver carcinomas. The histogenesis combined has remained unclear for many years. However, recent advances in hepatic progenitor cell (HPC) investigations have provided new insights. concept that originates from HPCs is adopted the chapter "combined hepatocellular-cholangiocarcinoma" latest World Health Organization (WHO) classification. In this study, we conducted clinicopathologic analysis according to WHO Fifty-four cases were...
Highlights•Liver injury in patients with COVID-19 is associated elevated IL-6 and coagulopathy.•Patients exhibit hepatic endotheliopathy which liver injury.•IL-6 trans-signaling causes sinusoidal endothelial cells.AbstractBackground AimsCOVID-19 interleukin-6 (IL-6). We hypothesized that cells (LSECs) leads to (a proinflammatory procoagulant state) COVID-19.MethodsCoagulopathy, endotheliopathy, alanine aminotransferase (ALT) were retrospectively analyzed a subset (n = 68), followed by larger...
Background/Aim: Lenvatinib is a potent inhibitor of receptor tyrosine kinases, targeting vascular endothelial growth factor receptors (VEGFR1-3), fibroblast (FGFR1-4), KIT, and RET. Here, we investigated the antiproliferative effects lenvatinib in liver cancer cells vitro vivo. Materials Methods: Eleven hepatocellular carcinoma cell lines two combined hepatocellular/cholangiocarcinoma were treated with 0-30 μM lenvatinib. Cell growth, apoptosis expression FGFR1-4, FGF19, substrate (FRS)2α...
Coronavirus disease (COVID-19) is characterized by pneumonia with secondary damage to multiple organs including the liver. Liver injury (elevated alanine aminotransferase [ALT] and aspartate [AST]) often correlates severity in COVID-19 patients. The aim of this study identify pathological microthrombi patient livers correlating their morphology liver injury, examine hyperfibrinogenemia von Willebrand factor (vWF) as mechanisms formation.Forty-three post-mortem biopsy samples from patients...
Aims The WHO classification describes that combined hepatocellular-cholangiocarcinoma, subtypes with stem-cell features, intermediate-cell subtype (CHC-INT) is composed of tumour cells features intermediate between hepatocytes and cholangiocytes. However, we previously reported CHC-INT showed a high positive rate biliary markers, but the expression hepatocyte paraffin (HepPar)-1 was low. In this study, examined other such as arginase-1 (Arg-1), keratin (K) 8 K18 in order to examine utility...
Background/Aim: Therapeutic targeting of receptor protein tyrosine kinases (PTKs) has proven successful in treating cancer. However, reports about PTKs prostate cancer are few. Elevated expression the erythropoietin-producing hepatocellular A2 (EPHA2) kinase, a transmembrane protein, is associated with poor prognosis certain types when enzyme dephosphorylated. This study investigated whether EPHA2 useful predicting biochemical recurrence Patients and Methods: Data from 241 patients who had...
Background/Aim: Recently, vessels encapsulating tumor clusters (VETC) pattern and macrotrabecular massive (MTM) of hepatocellular carcinoma (HCC) have been reported as aggressive histological types. These patterns showed an immunosuppressive immune microenvironment (TIME). Since there no reports on the differences these two subtypes simultaneously, this study examined immunophenotypes TIME MTM-HCC VETC-HCC immunohistochemically. Patients Methods: Seventy-four cases previously diagnosed HCC,...
Spleen stiffness is increased in liver cirrhosis (LC). We attempted to characterize the pathological features of spleen LC.We compared findings resected tissues 28 LC patients and those six healthy controls. In addition, we measured before splenectomy by shear wave elastography nine patients. After splenectomy, examined relationship between findings.Passive congestion was more frequently observed than controls (P < 0.01). The sinus wider spleens patients, diffuse α-smooth muscle actin (αSMA)...
Objective Limited information is available regarding the role of programmed death ligand 1 (PD‐L1) expression and CD8 + tumor‐infiltrating lymphocyte (TIL) density in tumor immune microenvironment (TIM) patients with salivary gland carcinoma (SGC). This study aimed to assess association between prognosis SGC probability PD‐L1 and/or cells using proportion score (TPS), mononuclear cell (MIDS), combined positive (CPS), TIL TIM. Study Design Retrospective cohort study. Methods We...
Aim Combined hepatocellular cholangiocarcinoma, subtype with stem‐cell features, intermediate‐cell (INT) shows various histological appearances and could be misdiagnosed as intrahepatic cholangiocarcinoma (iCCA). In the present study, we aimed to identify specific diagnostic markers of INT. Methods We extracted RNA from FFPE sections six INT, five iCCA, carcinoma (HCC) cases compared gene expression between HCC by microarray analysis. then undertook immunohistochemical (IHC) staining...
Aim We tried to characterize the pathological features of patients who developed hepatocellular carcinoma ( HCC ) with negative results both serous hepatitis B surface antigen and C virus antibody (non‐ , non‐ ). Methods In a multicenter study in K yushu, J apan, we studied histopathological characteristics non‐cancerous liver tissues 129 (103 men 26 women) . The histological damage was evaluated for fibrosis (stage) inflammation (grade) according L udwig classification chronic hepatitis....
Regulator of G-protein signaling (RGS) 5 acts as a GTPase-activating protein to negatively regulate signaling. RGS5 is reportedly related the invasion and metastasis cancers, such nonsmall lung cancer hepatocellular carcinoma. We examined expression its relationship with in squamous cell carcinoma (SCC) tongue. For immunohistochemical analysis RGS5, we used SCC tissues tongue obtained from 43 patients. between deepest point clinicopathological features. Because cancers are...
We aimed to compare the well-established liver fibrosis (LF) markers in Japanese patients with chronic hepatitis B (CHB, n = 331) and C (CHC, 886) discuss possible causes of differences results between CHB CHC patients.Virtual touch quantification (VTQ) acoustic radiation force impulse, Fibrosis-4 (Fib-4) index, aspartate aminotransferase platelet ratio index (APRI), hyaluronic acid (HA) were compared two cohorts. As an additional investigation, total collagen proportional area (TCPA, %) was...
Background/Aim: Assessment of the biological behavior tumors is important for choosing an appropriate cancer therapy. In hepatocellular carcinoma (HCC), behaviour can be assessed by tumor morphology and molecular biology. This study investigated usefulness tissue biopsy predicting HCC. Patients Methods: We studied 43 patients who underwent hepatectomy preoperative liver performed clinicopathological immunohistochemical (IHC) analyses. The expression following molecules was examined:...