A5010664147- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Breast Lesions and Carcinomas
- AI in cancer detection
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Respiratory Support and Mechanisms
- Infectious Diseases and Mycology
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- MRI in cancer diagnosis
- Sarcoma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Airway Management and Intubation Techniques
- Gut microbiota and health
- Reproductive tract infections research
- Ovarian cancer diagnosis and treatment
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- BRCA gene mutations in cancer
- Advanced Proteomics Techniques and Applications
- Cervical Cancer and HPV Research
- Cancer and Skin Lesions
Fudan University Shanghai Cancer Center
2022-2024
Southeast University
2024
Shanghai Medical College of Fudan University
2016-2023
Soochow University
2022-2023
Second Affiliated Hospital of Soochow University
2022-2023
Abstract Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 plasma samples originated from 147 CRC patients (CRCs) undergoing cetuximab with multi-course treatment, 90 healthy controls (HCs). COL12A1, THBS2, S100A8, S100A9 are screened as potential proteins to distinguish CRCs HCs both in tissue validation cohorts. We identify biomarkers (RRAS2, MMP8, FBLN1,...
Abstract Background Exploration of adaptive evolutionary changes at the genetic level in vaginal microbial communities during different stages cervical cancer remains limited. This study aimed to elucidate mutational profile microbiota throughout progression disease and subsequently establish diagnostic models. Methods utilized a metagenomic dataset consisting 151 subjects classified into four categories: invasive (CC) ( n = 42), intraepithelial neoplasia (CIN) 43), HPV-infected (HPVi)...
Abstract Aim Pathologists are currently supposed to be aware of both domestic and international guidelines for breast cancer diagnosis, but it is unclear how successfully these have been integrated into routine clinical practice in China. Thus, this national proficiency testing (PT) scheme pathology was set up conduct a baseline assessment the diagnostic capability pathologists Methods This PT plan designed implemented according “Conformity assessment—General requirements testing”...
Triple-negative breast cancer (TNBC) is the most challenging subtype. Molecular stratification and target therapy bring clinical benefit for TNBC patients, but it difficult to implement comprehensive molecular testing in practice. Here, using our multi-omics cohort (N=425), a deep learning-based framework was devised validated predictions of features, subtypes prognosis from pathological whole slide images (WSIs). The first incorporated neural network decompose tissue on WSIs, followed by...
The present study was conducted to evaluate the radiological findings, particularly ultrasonographic (US) characteristics of sclerosing adenosis (SA), and their correlation with histopathological results. A retrospective review identified 191 patients a total 200 lesions histopathologically confirmed as SA following breast surgery between July 2009 December 2012. Of patients, 145 (151 lesions) major component were included for US mammographic (MG) analysis. All analyzed female, mean age ±...
Abstract Background: With Trastuzumab deruxtecan (T-DXd) changing the anti-HER2 treatment paradigm, HER2-low (defined as IHC2+/ISH- and IHC1+) breast cancer patients have emerged a new targetable population. The lower threshold for HER2 expression that can benefit from HER2-directed antibody-drug conjugates (ADCs) is still being investigated, such immunohistochemistry (IHC) >0 to < 1+ IHC 0 with incomplete faint staining in ≤10% of tumor cells) DESTINY-Breast06 trial. Accurate...
Risk-reducing salpingo-oophorectomy (RRSO) is recommended for women at increased risk of breast and ovarian cancer. We launched a prospective study receiving RRSO, including those with mutations in genes beyond BRCA1/2.80 were enrolled RRSO sectioning extensively examining the fimbriae (SEE-FIM) protocol between October 2016 June 2022. The majority participants had inherited susceptibility gene or family history suggesting cancer risk, while patients isolated metastatic high-grade serous...
The significance of postoperative adjuvant radiotherapy (PORT) on the survival resected IIIA-N2 non-small cell lung cancer (NSCLC) remains controversial. Here, we aimed to determine predictive value three nodal classifications which might aid in PORT decision-making.A total 4797 patients with stage NSCLC were identified Surveillance, Epidemiology and End Results (SEER) database grouped by whether was administered. Survival analysis used identify patient groups who can benefit from PORT....
GTPase immunity-associated protein 7 (GIMAP7) has been previously recognized as a prognostic marker in pan-cancer. Our objective was to explore the function of GIMAP7 progression lung adenocarcinoma (LUAD). overexpressed by transfection with plasmid, and knocked down using siRNAs. The biological functions were examined employing CCK-8, EdU, colony formation, flow cytometry, wound healing, transwell assays. effects on extracellular acidification rate (ECAR), oxygen consumption (OCR), lactate...
Patients who underwent lobectomy resection are prone to hypoxemia, and the vast majority present with type I respiratory failure. Thus, improvement of hypoxemia is one most important factors facilitate postoperative recovery patients. In this study, superiority-inferiority different oxygen inhalation methods were compared high-flow nasal therapy (HFNO), noninvasive mechanical ventilation (NIMV) breath (NOB) in patients after single-port video-assisted thoracoscopic (VATS) lobectomy, clinical...