A5083791483- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Liver physiology and pathology
- Genetic factors in colorectal cancer
- Mitochondrial Function and Pathology
- Breast Lesions and Carcinomas
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer and Skin Lesions
- MicroRNA in disease regulation
- Insect Resistance and Genetics
- Chromatin Remodeling and Cancer
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Insect-Plant Interactions and Control
- BRCA gene mutations in cancer
- Endometrial and Cervical Cancer Treatments
- HER2/EGFR in Cancer Research
- Bioinformatics and Genomic Networks
- Insect and Pesticide Research
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
Fudan University Shanghai Cancer Center
2016-2025
Wuhan Sports University
2024-2025
Chinese Academy of Sciences
2015-2024
University of Hong Kong
2021-2024
Fudan University
2010-2024
Kunming Institute of Zoology
2015-2024
XinHua Hospital
2015-2024
Shanghai Jiao Tong University
2006-2024
Jilin Agricultural University
2015-2024
Shanghai Medical College of Fudan University
2015-2024
Abstract Introduction Profiling the spatial‐temporal expression pattern and characterizing regulatory networks of brain tissues are vital for understanding pathophysiology Alzheimer's disease (AD). Methods We performed a systematic integrated analysis profiles AD‐affected (684 AD 562 controls). A network‐based convergent functional genomic approach was used to prioritize possible regulator genes during development, followed by characterization. Results generated complete list differentially...
Abstract Granular cell tumors (GCTs) are rare that can arise in multiple anatomical locations, and characterized by abundant intracytoplasmic granules. The genetic drivers of GCTs currently unknown. Here, we apply whole-exome sequencing targeted analysis to reveal mutually exclusive, clonal, inactivating somatic mutations the endosomal pH regulators ATP6AP1 or ATP6AP2 72% GCTs. Silencing these genes vitro results impaired vesicle acidification, redistribution compartments, accumulation...
Pathogenic germline variants in ataxia-telangiectasia mutated (ATM), a gene that plays role DNA damage response and cell cycle checkpoints, confer an increased breast cancer (BC) risk. Here, we investigated the phenotypic characteristics landscape of somatic genetic alterations 24 BCs from ATM mutation carriers by whole-exome targeted sequencing. ATM-associated were consistently hormone receptor positive largely displayed minimal immune infiltrate. Although 79.2% these tumors exhibited loss...
Programmed cell death ligand 1 (PD-L1) is a potential predictive biomarker of the response to anti-PD-L1/anti- programmed (PD-1) therapy in multiple cancers, including triple negative breast cancer(TNBC). The purpose this study was investigate whether PD-L1 expression homogenous primary tumors(PTs) and synchronous axillary lymph node metastases(LNMs) TNBC.PD-L1 immunohistochemically evaluated 101 TNBC patients' PTs paired LNMs. tumor cells infiltrating immune or lymphocytes associated LNMs...
Objective We elected to analyze the correlation between pre-treatment apparent diffusion coefficient (ADC) and clinical, histological, immunohistochemical status of rectal cancers. Materials Methods Forty-nine cancer patients who received surgical resection without neoadjuvant therapy were selected that underwent primary MRI diffusion-weighted imaging (DWI). Tumor ADC values determined analyzed identify any correlations these CEA or CA19-9 levels, and/or histological properties tumor....
Lung cancer (LC) is a leading cause of cancer-related deaths worldwide. Its rapid growth requires hyperactive catabolism principal metabolic fuels. It unclear whether fructose, an abundant sugar in current diets, essential for LC. We demonstrated that, under the condition coexistence fuels body, fructose was readily used by LC cells vivo as glucose alternative via upregulating GLUT5, major transporter encoded solute carrier family 2 member 5 (SLC2A5). Metabolomic profiling coupled with...
Abstract Cotton plants accumulate phytotoxins, such as gossypol and related sesquiterpene aldehydes, to resist insect herbivores. The survival of insects exposed toxic secondary metabolites depends on the detoxification metabolism mediated by limited groups cytochrome P450. Gossypol has an antibiotic effect Aphis gossypii , concentrations were increased in present study, mortality cotton aphids from 4 28%. fecundity was also significantly reduced compared with control. transcriptional levels...
Alzheimer's disease is the most common neurodegenerative disease, and has a high level of genetic heritability population heterogeneity. In this study, we performed whole-exome sequencing Han Chinese patients with familial and/or early-onset followed by independent validation, imaging analysis function characterization. We identified an exome-wide significant rare missense variant rs3792646 (p.K420Q) in C7 gene discovery stage (P = 1.09 × 10-6, odds ratio 7.853) confirmed association...
Deubiquitinases (DUBs) and noncoding RNAs have been the subjects of recent extensive studies regarding their roles in lung cancer, but mechanisms involved are largely unknown. In our study, we used The Cancer Genome Atlas data set bioinformatics analyses identified USP21, a DUB, as potential contributor to oncogenesis non-small-cell cancer (NSCLC). We further demonstrated that USP21 was highly expressed NSCLCs. then conducted series vitro vivo assays explore effect on NSCLC progression...
Background Ki67 labeling index (LI) is critical for treatment options and prognosis evaluation in breast cancer. Visual assessment (VA) widely used to assess LI, but has some limitations. In this study, we compared the consistency between VA automated digital image analysis (DIA) of LI cancer, evaluate application value DIA assessment. Methods immunostained slides 155 cases primary invasive cancer were eyeballing assessed by five pathologists analyzed one pathologist respectively. Two score...
Ductal carcinoma in situ (DCIS) is a nonobligate precursor of invasive breast cancer. Here, we sought to investigate the level intralesion genetic heterogeneity DCIS and patterns clonal architecture changes progression from disease.Synchronous (n = 27) ductal carcinomas no special type (IDC-NSTs; n 26) 25 patients, pure 7) 7 patients were microdissected separately subjected high-depth whole-exome 56) or massively parallel sequencing targeting ≥410 key cancer-related genes 4). Somatic...
Uterine tumor resembling ovarian sex cord (UTROSCT) is a rare mesenchymal neoplasm that mainly harbors NCOA1-3 rearrangements with partner genes ESR1 or GREB1 . Here, we explored 23 UTROSCTs by targeted RNA sequencing. The association between molecular diversity and clinicopathologic features was investigated. mean age of our cohort 43 years (23-65 y). Only 15 patients (65%) were originally diagnosed UTROSCTs. Mitotic figures ranged from 1 to 7/10 high power fields, primary tumors increased...
Abstract Ferroptosis is a novel form of programmed cell death triggered by iron‐dependent lipid peroxidation and has been associated with various diseases, including cancer. Erastin, an inhibitor system Xc‐, which plays critical role in regulating ferroptosis, identified as inducer ferroptosis cancer cells. In this study, we investigated the impact butyrate, short‐chain fatty acid produced gut microbiota, on erastin‐induced lung Our results demonstrated that butyrate significantly enhanced...
Homologous Recombination Deficiency (HRD) is a predictive biomarker for ovarian cancer treated with PARP inhibitors or breast first-line platinum-based chemotherapy. However, limited research documented on treatment prediction HRD as in patients, especially the Chinese population.We investigated association between status and response of chemotherapy 240 HGSOC patients.The Pt-sensitive patients showed higher scores than Pt-resistant ones, but this was not significant(median: 42.6 vs. 31.6, p...
We measured net carbon flux (FCO2) and H2O (FH2O) by the eddy-covariance method at three Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco)–western hemlock (Tsuga heterophylla (Raf.) Sarg.) sites located in Wind River Valley of southern Washington State, USA. Stands were approximately 20, 40 450 years old measurements made between June 15 October 1998 40- 450-year-old stands, 1999 20- stands. Our objectives to determine if there differences among stands in: (1) patterns daytime FCO2 during...
GATA-binding protein 3 (GATA3) is a sensitive and relatively specific marker in breast urothelial carcinomas. Its diagnostic utility primary metastatic cancers has been explored confirmed. However, the relationship between GATA3 expression different carcinoma intrinsic subtypes not specifically defined literature despite few reports with small number of cases. The aim current investigation to clarify among histological surrogate molecular large series cases.Immunohistochemical staining...