A5101545533- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Mast cells and histamine
- Microtubule and mitosis dynamics
- Diet, Metabolism, and Disease
- Advanced Fluorescence Microscopy Techniques
- Metabolomics and Mass Spectrometry Studies
- Cell Image Analysis Techniques
- Cellular Mechanics and Interactions
- Chemical Synthesis and Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Heat shock proteins research
- Glutathione Transferases and Polymorphisms
- Immune cells in cancer
- Liver physiology and pathology
- Cancer Genomics and Diagnostics
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2019-2022
Shanghai University of Traditional Chinese Medicine
2019-2022
Chengdu Medical College
2017-2022
University of Florida
2021-2022
Hubei University of Medicine
2018-2021
Guilin Medical University
2019
State Key Laboratory of Oncogene and Related Genes
2014-2016
Shanghai Cancer Institute
2014-2016
Renji Hospital
2014-2016
Shanghai Jiao Tong University
2014-2016
Lung cancer (LC) is a leading cause of cancer-related deaths worldwide. Its rapid growth requires hyperactive catabolism principal metabolic fuels. It unclear whether fructose, an abundant sugar in current diets, essential for LC. We demonstrated that, under the condition coexistence fuels body, fructose was readily used by LC cells vivo as glucose alternative via upregulating GLUT5, major transporter encoded solute carrier family 2 member 5 (SLC2A5). Metabolomic profiling coupled with...
Recent studies revealed that emodin extracted from Chinese herbs exhibits an anticancer effect on different cancer types, including colon cancer. However, the mechanism is not well understood. In our study, we confirmed treatment inhibited cell viability and induced apoptosis in cells. Further experiments found was also able to induce autophagy, which indispensible for by emodin. More interestingly, results mitochondrial dysfunction ROS accumulation Finally, stressed essential autophagy...
Esophageal squamous cell carcinoma (ESCC) is a major histological subtype of esophageal cancer with inferior prognosis. Here, we conducted comprehensive transcriptomic, proteomic, phosphoproteomic, and metabolomic characterization human, treatment-naive ESCC paired normal adjacent tissues (cohort 1, n = 24) in an effort to identify new molecular vulnerabilities for potential therapeutic targets. Integrative analysis revealed small group genes that were related the active posttranscriptional...
Heat shock protein 27 (Hsp27) is an ATP-independent molecular chaperone and confers survival advantages resistance to cancer cells under stress conditions. The effects mechanisms of Hsp27 in HCC invasion metastasis are still unclear. In this study, hepatocellular carcinoma (HCC) tissue array (n = 167) was used investigate the expression prognostic relevance patients. patients with high exhibited poor prognosis. Overexpression led forced cells, whereas silencing attenuated vitro vivo. We...
Hypoxic microenvironment is a powerful driving force for the invasion and metastasis of hepatocellular carcinoma (HCC). Hypoxia-inducible factor 1α (HIF-1α), as crucial regulator transcriptional responses to hypoxia, induces expression multiple target genes involved in different steps HCC metastatic process. It critical find associated with under hypoxia shedding new light on molecular mechanism metastasis. In this study, we uncovered that could induce upregulation Rab11-family interacting...
Esophageal squamous cell carcinoma (ESCC) is a major histological subtype of esophageal cancer with poor prognosis. Although several serum metabolomic investigations have been reported, ESCC tumor-associated metabolic alterations and predictive biomarkers in sera not defined. Here, we enrolled 34 treatment-naive patients collected their pre- post-esophagectomy together the from healthy volunteers for survey. Our comprehensive analysis identified as represented by panel 12 metabolites....
miR-1284 has been reported to inhibit tumor growth in some human cancers, including lung cancer, ovarian and gastric cancer. Whether it regulates breast cancer progression remains elusive. In this study, we found that was downregulated tissues cell lines compared normal control cells. Moreover, showed overexpression of significantly inhibited the proliferation, migration, invasion cells while promoting apoptosis. terms mechanism, transcription factor ZIC2 a target Through luciferase reporter...
The aim of this study is to investigate the effects inhibiting Aurora-B on osteosarcoma (OS) cell malignant phenotype, phosphorylation valosin-containing protein (VCP), and activity NF-κB signaling in vitro. expressions p-VCP proteins were detected by immunohistochemistry 24 OS tissues, relationship between was investigated. results showed that there a positive correlation proteins. expression human lines U2-OS HOS cells inhibited specific short hairpin RNA (shRNA) lentivirus (AURKB-shRNA...
Breast cancer is one of the most common malignancies and leading cause women's death, breast cancers are estrogen receptor-positive (ER+) which can develop into advanced stage from early with treatment resistance. The purpose this study was to investigate anti-ER+ effects 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG) its possible mechanisms. Cell viability analyzed by MTT assay. cell cycle distribution apoptosis were detected Flow cytometry. expressions proliferation- apoptosis-related...
The interaction between platelets and vascular endothelial cells plays a pivotal role in the pathophysiology of acute ischemic stroke (AIS), especially atherosclerosis formation. However, underlying mechanism is not entirely clear. aim this study was to elucidate platelets-derived miRNA development AIS. We evaluated expression profiles serum microvesicles (MV) five AIS patients healthy controls using RNA-seq, then measured levels selected derived miRNAs by qRT-PCR. miR-200a-3p MV had...
Metabolic reprogramming is a core hallmark of cancer and key for tumorigenesis tumor progression. Investigation metabolic perturbation by anti-cancer compounds would allow thorough understanding the underlying mechanisms these agents identification new targets. Here, we demonstrated that administration oleanolic acid (OA) rapidly altered metabolism, particularly suppressing purine salvage pathway (PSP). PSP restoration significantly opposed OA-induced DNA replication cell proliferation...
Platelet-derived growth factor BB (PDGF-BB) regulates vascular smooth muscle cells (VSMCs) by activating signaling cascades that promote vasoconstriction and growth, but the underlying mechanisms remain incompletely characterized. In this study, we aimed at investigating role of spleen tyrosine kinase (Syk) in proliferation phenotypes rat pulmonary arterial VSMCs. Our results demonstrate PDGF-BB or Syk-adenovirus led to a substantial increase VSMCs cytoskeleton rearrangement Consistently,...
CERS2(ceramide synthase 2)又称LASS2(homo sapiens longevity assurance homologue 2 of yeast LAGl).对CERS2基因的研究主要集中在肝癌,它不仅可抑制肝癌细胞的增殖[1],还可抑制其转移[2].那么,CERS2基因在乳腺肿瘤中的表达如何,是否具有临床意义呢?我们通过检测浸润性乳腺癌组织标本和乳腺良性肿瘤及正常乳腺组织中CERS2基因的表达,进一步探讨其临床意义,为浸润性乳腺癌的诊断和治疗提供可能的分子靶点及预后评价指标。
Long-term multi-functional imaging and analysis of live cells require streamlined, functional coordination various hardware software platforms. However, manual control equipment produced by different manufacturers is labor-intensive time-consuming, potentially decreasing the accuracy, reproducibility, quality acquired data. Therefore, an all-in-one user-programmable system that enables automatic, multi-functional, long-term image acquisition compatible with most fluorescent microscopy...
Automatic operations of multi-functional and time-lapse live-cell imaging are necessary for the biomedical science community to study active, multi-faceted, long-term biological phenomena. To achieve automatic control, most existing solutions often require purchase extra software programs hardware that rely on manufacturers' own specifications. However, these usually non-user-programmable unaffordable many laboratories. address this unmet need, we have developed a novel open-source program,...
Abstract Esophageal squamous cell carcinoma (ESCC) is a major histological subtype of esophageal cancer with dismal prognosis. Although several serum metabolomic investigations have been reported, ESCC tumor-associated metabolic alterations along predictive biomarkers in sera were not defined. Here we enrolled 34 treatment-naive patients and collected their pre-and post-esophagectomy together from healthy volunteers for survey. Our comprehensive analysis discerned as represented by panel 12...
RNA modification is a regulation at the post-transcriptional level. methylation accounts for more than 60% of all modifications, and m[superscript 6]A(6-methyladenine) most common type on mRNA higher organisms. The level transcription 6]A dynamically regulated by methyltransferase (reader), binding protein (writer) demethylase (eraser). Furthermore, has been found to have an impact tumor initiation progression through various mechanisms.13 genes related from gene expressions in Cancer Genome...
Abstract Hepatocellular carcinoma (HCC) is intrinsically resistant to conventional chemotherapies. Developing effective therapeutics becomes critical tackle the unmet medical need. The fibroblast growth factor/fibroblast factor receptor (FGF/FGFR) signaling axis plays an important role in liver development and homeostasis adults. Deregulation of FGF/FGFR pathway through genetic modification or overexpression receptors (or their ligands) has been increasingly recognized HCC. Accordingly,...