A5101981891- Liver Disease Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Nutritional Studies and Diet
- PARP inhibition in cancer therapy
- Advanced Neuroimaging Techniques and Applications
- Calcium signaling and nucleotide metabolism
- Trace Elements in Health
- Metabolomics and Mass Spectrometry Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Soil Mechanics and Vehicle Dynamics
- Cardiovascular and exercise physiology
- Cardiovascular Health and Disease Prevention
- Granular flow and fluidized beds
- Cardiovascular Health and Risk Factors
- Heart Rate Variability and Autonomic Control
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
- Heavy Metal Exposure and Toxicity
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Aluminum toxicity and tolerance in plants and animals
- Advanced Optical Sensing Technologies
- Transportation Planning and Optimization
- Mathematics, Computing, and Information Processing
- Agricultural Engineering and Mechanization
Changzhi Medical College
2024-2025
Tianjin Medical University
2025
Kunming Medical University
2025
Kunming Children's Hospital
2025
Capital Medical University
2025
Beijing Anzhen Hospital
2025
Sichuan Agricultural University
2019-2024
Institute of Hydrobiology
2024
Chinese Academy of Sciences
2024
Zhongnan Hospital of Wuhan University
2024
NAD+, nicotinamide adenine dinucleotide, is mostly described to associate with the aging process. We aimed investigate association between human whole blood NAD+ contents and in a relative large-scale community-based population further address gender impact on this association.We recruited 1,518 participants aged over 18 years old free of cardiovascular any type cancer from Jidong community 2019 2020. Whole level was measured by cycling assay LC-mass spectroscopy assay. The chronological age...
Hypoxic microenvironment is a powerful driving force for the invasion and metastasis of hepatocellular carcinoma (HCC). Hypoxia-inducible factor 1α (HIF-1α), as crucial regulator transcriptional responses to hypoxia, induces expression multiple target genes involved in different steps HCC metastatic process. It critical find associated with under hypoxia shedding new light on molecular mechanism metastasis. In this study, we uncovered that could induce upregulation Rab11-family interacting...
Non-alcoholic fatty liver disease (NAFLD) and cognitive impairment are common aging-related disorders. This study aims to explore the changes of function in middle-aged elderly population with NAFLD from a Jidong cohort.A total 1,651 participants (>40 years) without were recruited into current 2015 followed up until 2019. Abdominal ultrasonography was used for diagnosis NAFLD. Global assessed Mini-Mental State Examination (MMSE). Cognitive defined as score <18 illiterates, <21 primary school...
Metabolic syndrome (MetS) has been proposed as a clinically identifiable high-risk state for the prediction and prevention of cardiovascular diseases type 2 diabetes mellitus. As promising "omics" technology, metabolomics provides an innovative strategy to gain deeper understanding pathophysiology MetS. The study aimed systematically investigate metabolic alterations in MetS identify biomarker panels identification using machine learning methods.
Background: To examine the effect of triglyceride-glucose (TyG) index on longitudinal cognitive decline in a healthy middle-aged-to-elderly population. Methods: We conducted population-based study. A total 1774 participants without impairment were enrolled 4-year follow-up. They divided into four groups according to quartile TyG index. Multivariable-adjusted Cox proportional hazard models performed association between and decline. Discrimination tests used evaluate incremental predictive...
BACKGROUND IL-22 plays a pivotal role in the processes of inflammation and tissue healing., but its cholangiocarcinoma (CCA) remains unclear. our study explored IL-22/IL-22R1 pathway impact on CCA progression through ERK1/2 signaling cascade. AIM To determine mechanism provide new directions for clinical treatment. METHODS IL-22R1 expression was assessed human rat tissues utilizing immunohistochemical techniques, Western blot analysis, quantitative reverse transcription PCR. The cells vitro...
ABSTRACT Purpose Structural changes during depressive episodes in adolescents with major disorder (MDD) remains unclear due to participant heterogeneity, illness chronicity, and medication confounders. This study aimed explore white matter (WM) microstructural first‐episode, treatment‐naïve MDD using an integrated diffusion tensor imaging (DTI) approach. Method We recruited 66 subjects, including 37 29 healthy controls. Two main DTI techniques, automated fiber quantification (AFQ)...
Background/Aims: Non-small cell lung carcinoma (NSCLC) is the most common type of cancer and cause cancer-related deaths. The molecular mechanisms that are involved in NSCLC development currently not well understood. Accumulating evidence shows histone demethylases play important roles regulation pathological developmental processes many diseases, including various types cancers. Methods: Mitochondrial membrane potential assays, migration invasion caspase-3 caspase-9 activity assays western...
Abstract Purpose By recruiting reference population, we aimed to (1): estimate the 25(OH)D threshold that maximally inhibits PTH, which can be defined as cutoff value for vitamin D sufficiency; (2) establish PTH interval (RI) in population with sufficient D. Methods Study data were retrieved from LIS (Laboratory Information Management System) under literature suggested criteria, and outliers excluded using Tukey fence method. Locally weighted regression (LOESS) segmented (SR) conducted of...
The discrete element method (DEM) is an effective tool for obtaining qualitative and quantitative information on particle motion, which aids in the design optimization of agricultural equipment structures. accuracy DEM simulation parameters significantly impacts results. This study employed a combination high-speed camera measurement, simulation, validation tests to determine material interaction property fertilizer particles. basic (triaxial size, bulk density, coefficient static friction)...
Background Nicotinamide adenine dinucleotide (NAD + ) is a coenzyme and plays crucial role in several metabolic processes. This study explored the association of nicotinamide levels with disease (MD) adults. Methods In this cross-sectional study, all data were collected from Jidong community. MD was defined as presence one or more following components: hypertension, dyslipidemia, diabetes, hyperuricemia, obesity, non-alcoholic fatty liver (NAFLD). The components categorized into three...
Abstract Longevity assurance homolog 2 of yeast LAG1 (LASS2) has been reported to act as an important tumor suppressor in the development human cancers. However, little is known about prognostic value LASS2 hepatocellular carcinoma (HCC) . In present study, we analyzed correlation between and TGF-β1 levels, evaluated their values HCC patients. We first expression two independent cohorts (test cohort: 184 patients; validation 118 patients) using immunohistochemistry (IHC). Kaplan-Meier...
Nicotinamide adenine dinucleotide (NAD+ ) level is the protective factor of cardiovascular diseases (CVDs). In addition, anaemia a risk adverse outcomes in women. However, there are limited data about association between NAD+ and anaemia. The aim this study was to evaluate with among A total 727 females from Jidong community were included current analysis. levels tested by cycling assay HPLC using whole blood samples. Anaemia determined haemoglobin (Hb) concentration, subtypes further...