A5048387368- Vagus Nerve Stimulation Research
- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Studies
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Heart Rate Variability and Autonomic Control
- Traditional Chinese Medicine Analysis
- EEG and Brain-Computer Interfaces
- Healthcare and Venom Research
- Functional Brain Connectivity Studies
- Gastrointestinal motility and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Flavonoids in Medical Research
- Medical Research and Treatments
- Anesthesia and Neurotoxicity Research
- Sleep and Wakefulness Research
- Gastrointestinal Tumor Research and Treatment
- Nicotinic Acetylcholine Receptors Study
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Transcranial Magnetic Stimulation Studies
- Pharmacological Effects of Natural Compounds
Chengdu Institute of Biology
2021-2025
Peking University First Hospital
2025
Peking University
2013-2025
Changzhi Medical College
2021-2025
National Clinical Research Center for Digestive Diseases
2022-2025
Chinese Academy of Sciences
2021-2025
Soochow University
2024-2025
University of Chinese Academy of Sciences
2025
Northeast Forestry University
2025
Chinese PLA General Hospital
2023-2025
Mounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases premature mortality later in life. One mechanistic hypothesis for this phenomenon is early life adversity alters the expression or functioning of glucocorticoid receptor (GR) throughout course thereby increases sensitivity inflammatory stimulation. An exaggerated pro-inflammatory response generally considered be a key cause postoperative cognitive dysfunction (POCD). The aim study was...
Stress-induced neuroinflammation was considered to play a critical role in the pathogenesis of depression. Transcutaneous auricular vagus nerve stimulation (taVNS) is relatively non-invasive alternative treatment for patients suffering from major depressive disorder. The anti-inflammatory signal mediated by α7 nicotinic acetylcholine receptor (α7nAchR), and hippocampus, region with most distribution α7nAchR, regulates emotions. Here, we investigated α7nAchR mediating hippocampal taVNS...
There are 9.9 million new cases of dementia in the world every year. Short-term conversion rate from mild cognitive impairment (MCI) to is between 20% and 40%, but long-term 5-10 years ranges 60% 100%. It particularly important prevent or prolong development MCI into dementia. Both auriculotherapy vagus nerve stimulation effective on improving functions. However, there no double blinded randomized clinical trial support effectiveness transcutaneous electrical auricular acupoints patients...
Postoperative ileus after colorectal surgery is a frequent problem that significantly delays recovery, increases perioperative costs, and negatively impacts on daily life, physical psychosocial functioning, wellbeing. We investigated the effect of acupuncture at different single acupoint combined with standard care postoperative ileus.In this single-centre, three-arm, prospective, randomised trial, we enrolled patients primary cancer undergoing elective resection Cancer Hospital Chinese...
Abstract Background Transcutaneous auricular vagus nerve stimulation (taVNS) is a vital neuromodulation for the treatment of depression, but its antidepressant molecular mechanism unclear. The α7 nicotinic acetylcholine receptor (α7nAchR) key mediator that mediates anti‐inflammatory efficacy. Here, we investigated whether effect taVNS in chronic unpredicted mild stress (CUMS)‐exposed rats works through α7nAchR/JAK2/STAT3/NF‐κB pathway. Methods depression model was established by CUMS...
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the distributed over body surface. Studies suggest a correlation between brain-gut-microbiota (BGM) axis and pathogenesis Alzheimer’s disease (AD). The BGM represents complex bidirectional communication system, with being crucial component. Therefore, electrical might have potential modify—most time probably in non-physiological way—the signal transmission within axis,...
Both animal experiments and clinical trials have confirmed that transcutaneous vagus nerve stimulation (taVNS) at auricular concha region has a curative effect on depression. However, there been no clear evidence showing any of the frequencies is superior to others. This study aimed explore different antidepressant effects three taVNS chronic unpredictable mild stress (CUMS) depression model rats. In our experiment, 50 male Sprague-Dawley rats were randomly divided into five groups, i.e....
Transcutaneous auricular vagus nerve stimulation was recently reported to have a therapeutic potential for functional dyspepsia (FD). This study aimed explore the integrative effects and mechanisms of (aVNS) in rodent model FD.We evaluated aVNS on visceral hypersensitivity, gastric motility open field test (OFT) activity iodoacetamide (IA)-treated rats. The autonomic function assessed; blood samples tissues were collected analyzed by an enzyme-linked immunosorbent assay western blot....
IMPORTANCE Evidence from randomized clinical trials of transcutaneous auricular vagus nerve stimulation (taVNS) for chronic insomnia disorder is lacking. OBJECTIVE To evaluate the efficacy and safety taVNS compared with sham taVNS. DESIGN, SETTING, PARTICIPANTS This trial was conducted October 2021 to December 2022 at a single center in Beijing, China. Patients Pittsburgh Sleep Quality Index (PSQI) least 8 were enrolled. Statistical analysis performed June September 2023. INTERVENTIONS...
Abstract To investigate the efficacy of laser acupuncture and photobiomodulation therapy in alleviating symptoms among patients diagnosed with Bell’s palsy duration greater than 8 weeks. The randomized controlled trial has been performed from May 2021 to April 2023. Patients were eligible who had weeks on out-patient Department Otorhinolaryngology Beijing Tongren Hospital. group received class IV treatment for 3 times per weeks, a total 72 times. control same procedure except parameter....
Abstract Background Depression is a common psychiatric disorder in diabetic patients. Depressive mood associated with obesity/metabolic disorders related to the inflammatory response caused by long‐term consumption of high‐fat diets, but its molecular mechanism unclear. In this study, we investigated whether antidepressant effect transcutaneous auricular vagus nerve stimulation (taVNS) diet rats works through P2X7R/NLRP3/IL‐1β pathway. Methods We first used 16S rRNA gene sequencing analysis...
Protein kinase A (PKA)/cAMP response element-binding (CREB) protein signaling pathway, contributing to impaired neurogenesis parallel depressive-like behaviors, has been identified as the crucial factor involved in antidepressant of acupuncture. However, molecular mechanisms associated with acupuncture, neurogenesis, and behaviors ameliorating remain unexplored. The objective was identify underlying acupuncture through PKA pathway depression rats by employing inhibitor H89 vivo experiments....