A5011885000- Acupuncture Treatment Research Studies
- Psychosomatic Disorders and Their Treatments
- Vagus Nerve Stimulation Research
- Pain Management and Placebo Effect
- Heart Rate Variability and Autonomic Control
- Migraine and Headache Studies
- Pain Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Healthcare and Venom Research
- Musculoskeletal pain and rehabilitation
- Neurological disorders and treatments
- Traditional Chinese Medicine Studies
- Alzheimer's disease research and treatments
- Hand Gesture Recognition Systems
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Osteoarthritis Treatment and Mechanisms
- Biochemical effects in animals
- Tea Polyphenols and Effects
- EEG and Brain-Computer Interfaces
- Voice and Speech Disorders
- Pain Management and Treatment
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
Beijing University of Chinese Medicine
2014-2025
Massachusetts General Hospital
2013-2022
Harvard University
2013-2022
Athinoula A. Martinos Center for Biomedical Imaging
2021
Imaging Center
2021
Weatherford College
2019
Purdue University West Lafayette
2018
Zhongshan Hospital
2011
Pennsylvania State University
2009
Migraine is a common episodic neurological disorder. Literature has shown that transcutaneous auricular vagus nerve stimulation (taVNS) at 1 Hz can significantly relieve migraine symptoms. However, its underlying mechanism remains unclear. This study aims to investigate the neural pathways associated with taVNS treatment of migraine.Twenty-nine patients were recruited from outpatient neurology clinics. Each patient attended two magnetic resonance imaging/functional imaging (MRI/fMRI) scan...
Despite the high prevalence and socioeconomic impact of chronic low back pain (cLBP), treatments for cLBP are often unsatisfactory, effectiveness varies widely across patients. Recent neuroimaging studies have demonstrated abnormal resting-state functional connectivity (rsFC) default mode, salience, central executive, sensorimotor networks in patients, but their role as predictors treatment responsiveness has not yet been explored. In this study, we used machine learning approaches to test...
Vagus nerve stimulation (VNS) is an emerging electroceutical therapy for remedying gastric disorders that are poorly managed by pharmacological treatments and/or dietary changes. Such seems promising as the vagovagal neurocircuitry modulates enteric nervous system to influence functions.Here, modulatory effects of left cervical VNS on emptying in rats were quantified using a (i) feeding protocol which animal voluntarily consumed postfast, gadolinium-labeled meal and (ii) non-invasive imaging...
Chronic low back pain (cLBP) is a prevalent disorder. A growing body of evidence linking the pathology reward network to chronic suggests that sensitization may contribute cLBP chronification via disruptions mesocortical and mesolimbic circuits in system. Resting-state (RS) functional magnetic resonance imaging (fMRI) data was acquired from 90 patients with 74 matched pain-free controls (HCs) at baseline after manipulation for intensification. The ventral tegmental area (VTA) chosen as seed...
Objective: Investigating the effects of electro-acupuncture (EA) treatment on mice with Alzheimer's disease (AD), using Morris water maze (MWM) for spatial learning and memory behavior tests combined micro-positron emission tomography (micro-PET) imaging glucose metabolism in hippocampus. Methods: Thirty seven-month-old APP/PS1 were randomly divided into AD Model group (AD group), medicine (M group) EA group, C57BL/6 used Normal control (N n = 10 each group. Mice M received donepezil...
Acupuncture can provide therapeutic analgesic benefits but is limited by its cost and scheduling difficulties. Guided imagery a commonly used method for treating many disorders, such as chronic pain. The present study examined novel intervention pain relief that integrates acupuncture with called video-guided treatment (VGAIT). A total of 27 healthy subjects were recruited crossover-design included 5 sessions administered in randomized order (i.e., baseline 4 different interventions). We...
A growing body of evidence suggests that transcutaneous auricular vagus nerve stimulation (taVNS) may relieve symptoms migraineurs. Frequency is one the key parameters. The aim this study to investigate modulation effect taVNS frequency on descending pain system (DPMS) in patients with migraine.Twenty-four episodic migraineurs without aura (21 females) were recruited for single-blind, crossover, functional magnetic resonance imaging (fMRI) study. Each participant attended two separate fMRI...
Objectives: Non-invasive brain stimulation (NIBS) is an emerging tool for treating autism spectrum disorder (ASD). Exploring new targets may improve the efficacy of NIBS ASD. Materials and Methods: We first conducted a meta-analysis on 170 functional magnetic resonance imaging studies to identify ASD-associated regions. then performed resting-state connectivity analysis in 70 individuals with ASD investigate surface regions correlated these potential Results: found that medial prefrontal...
Abstract Background Migraine is a neurological disease with significant genetic component and characterized by recurrent prolonged episodes of headache. Previous epidemiological studies have reported higher risk dementia in migraine patients. Neuroimaging also shown structural brain atrophy regions that are common to dementia. However, these observational cannot establish causality. The present study aims explore the causal relationship between dementia, as well mediation roles changes this...
<title>Abstract</title> Wearable silent speech systems hold significant potential for restoring communication in patients with impairments. However, seamless, coherent remains elusive, and clinical efficacy is still unproven. Here, we present an AI-driven intelligent throat (IT) system that integrates muscle vibrations carotid pulse signal sensors large language model (LLM) processing to enable fluent, emotionally expressive communication. The utilizes ultrasensitive textile strain capture...
Abstract As an emerging neuromodulation technique, transcutaneous auricular vagus nerve stimulation (taVNS) has shown promise in enhancing cognitive abilities. The present study used a combination of the go/no-go task and stop-signal experimental paradigm to examine effects taVNS on participants' EEG measures. Sixty-one healthy participants were randomly assigned either group or sham group. Participants received 100 Hz 25 counterbalanced order. We compared behavioral data before after...
Increased amyloid- β (A ) plaque deposition is thought to be the main cause of Alzheimer’s disease (AD). -Site amyloid precursor protein cleaving enzyme 1 (BACE1) key involved in A peptide generation. Excessive expression BACE1 might overproduction neurotoxins central nervous system. Previous studies indicated that initially cleaves (APP) and may subsequently interfere with physiological functions proteins such as PKA, which recognized closely associated long-term potentiation (LTP) level...
Acupuncture and imagery interventions for pain management have a long history. The present study comparatively investigated whether acupuncture video-guided treatment (VGAIT, watching video of on the participant's own body while imagining it being applied) could modulate brain regional connectivity to produce analgesic effects. also examined pre-intervention functional structural features be used predict magnitude Twenty-four healthy participants were recruited received four different (real...
The dynamic nature of resting-state functional magnetic resonance imaging (fMRI) brain activity and connectivity has drawn great interest in the past decade. Specific temporal properties fMRI dynamics, including metrics such as occurrence rate transitions, have been associated with cognition behaviors, indicating existence mechanism distruption neuropsychiatric disorders. development new methods to manipulate dynamics will advance our understanding these pathophysiological mechanisms from...
Scalp acupuncture is a modality of in which needles are inserted into certain layer the scalp order to affect function corresponding areas cerebral cortex and relieve symptoms. Clinical studies have demonstrated potential as non-pharmacological treatment for dementia. Unfortunately, recent findings from brain neuroimaging on dementia not been incorporated acupuncture. This study aims integrate meta-analysis, resting-state functional connectivity, diffusion tensor imaging (DTI) identify...