A5101596287- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Ovarian function and disorders
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Reproductive Health and Technologies
- Tuberculosis Research and Epidemiology
- Sexual Differentiation and Disorders
- Birth, Development, and Health
- RNA modifications and cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive Health and Contraception
- Molecular Biology Techniques and Applications
- Pregnancy and preeclampsia studies
- RNA regulation and disease
- Anesthesia and Neurotoxicity Research
- Genital Health and Disease
- Essential Oils and Antimicrobial Activity
- Textile materials and evaluations
- Reproductive tract infections research
- Reproductive System and Pregnancy
- Male Reproductive Health Studies
- Ectopic Pregnancy Diagnosis and Management
- Bee Products Chemical Analysis
- Carbohydrate Chemistry and Synthesis
University of Toronto
2015-2025
Second Affiliated Hospital of Inner Mongolia Medical University
2017-2025
Wuhan Polytechnic University
2024
Children's Hospital of Fudan University
2023
Wenzhou Medical University
2021-2023
National Health and Family Planning Commission
2015-2021
Sun Yat-sen University
2012-2020
Xi'an Chest Hospital
2012-2019
Shandong Maternal and Child Health Hospital
2019
Wuhan University
2018
Head and neck cancer is the fifth most common type of worldwide remains challenging for effective treatment due to proximity critical anatomical structures in head region, which increases probability toxicity from surgery radiotherapy, therefore emphasizes importance maximizing targeted ablation.We have assessed effectiveness porphysome nanoparticles enhance fluorescence photoacoustic imaging tumors rabbit hamster models.In addition, we evaluated this agent localized photothermal ablative...
Manuka honey (MH) is a highly prized natural product from the nectar of Leptospermum scoparium flowers. Increased competition on global market drives MH innovations. This review updates comparative and non-comparative studies to highlight nutritional, therapeutic, bioengineering, cosmetic values MH. good source phenolics unique chemical compounds, such as methylglyoxal, dihydroxyacetone, leptosperin glyoxal, methylsyringate leptosin. Based evidence in vitro, vivo clinical studies,...
To investigate the biomechanical efficacy of reverse suture anchor (RSA) technique compared with transtibial pull-out (TP) and (SA) techniques using in vitro porcine knee models PMMRTs. 32 fresh frozen tibiae medial meniscus intact were randomly assigned to four groups (eight specimens each). A standardized posterior root tear (PMMRT) was established 24 specimens. SA, TP, RSA used repair PMMRTs 8 respectively, while native roots (PMMRs) left as a control eight Pressure sensitivity, stress,...
Abstract Background In vertebrates, most protein-coding genes have a peak of GC-content near their 5′ transcriptional start site (TSS). This feature promotes both the efficient nuclear export and translation mRNAs. Despite importance for RNA metabolism, its general features, origin, maintenance remain mysterious. We investigate evolutionary forces shaping at (TSS) through comparative genomic analysis nucleotide substitution rates between different species by examining human de novo...
Tens of million cases coronavirus disease-2019 (COVID-19) have occurred globally. The severe acute respiratory syndrome 2 (SARS-CoV-2) attacks the system, causing pneumonia and lymphopenia in infected individuals. aim present study is to investigate laboratory characteristics viral load, lymphocyte subset cytokines asymptomatic individuals with SARS-CoV-2 infection comparison those symptomatic patients COVID-19.From January 24, 2020, April 11, 48 consecutive subjects were enrolled this...
Summary The pathogenesis of recurrent spontaneous abortion (RSA) is multi‐factorial, complex and poorly understood. In the present study, semen parameters, including sperm chromatin integrity, concentration, motility morphology, were compared between 111 men whose partners had a history unexplained RSA (RSA group) 30 healthy fertile (control group). group was further separated into three subgroups, depending on their reproductive outcome during 12 months after they enrolled in study:...
Background This study observes changes in levels of seminal nitric oxide (NO), synthase (NOS), macrophage migration inhibitory factor (MIF), sperm DNA integrity, chromatin condensation and Caspase-3in adult healthy men after scrotal heat stress (SHS). Methods Exposure the scrotum 25 male volunteers locally at 40–43°C SHS belt warming 40 min each day for successive 2 d per week. The course was continuously 3 months. Routine semen analysis, hypo-osmotic swelling (HOS) test, Aniline blue (AB)...
Abstract RNA and proteins can have diverse isoforms due to post-transcriptional post-translational modifications. A fundamental question is whether these are mostly beneficial or the result of noisy molecular processes. To assess plausibility explanations, we developed mathematical models depicting different regulatory architectures investigated isoform evolution under multiple population genetic regimes. We found that factors beyond selection, such as effective size number cis -acting loci,...
BackgroundThe extract of Platycodon grandiflorum has been reported to have effective spermicidal activity. This study was designed evaluate the and contraceptive activity, as well safety, Platycodin D (PD), a major saponin in grandiflorum. MethodsUsing computer-aided sperm analysis (CASA) test criteria, sperm-immobilizing activity PD studied using highly motile human sperm. The viability assessed by fluorescent staining SYBR-14 (living sperm) propidium iodide (dead sperm). membrane integrity...
Objective This study aimed to evaluate the role of hippocampal 5-hydroxytryptamine-1A (5-HT1A)-mediated cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signalling pathway in sevoflurane-induced cognitive dysfunction aged rats. Methods Sixty 18-month-old Sprague–Dawley rats were divided into control (n = 30) and experimental (Sev, n groups. The group inhaled 50% air/oxygen mixture (2 L/min) 2% sevoflurane for 4 hours. Morris water maze test was performed mRNA expression 5-HT1A...
Abstract Infertility is currently a major public health problem. Anti-sperm antibodies (ASAs) markedly reduce sperm quality, which can subsequently lead to male and/or female infertility. The accurate detection of ASAs derived from specific spermatozoa is, therefore, clinically useful. We have focused on the spermatozoa-specific expression protein ACTL7a for many years and developed an enzyme-linked immunosorbent assay (ELISA) detect concentration anti-ACTL7a in fertile sera ( n = 267)...
Type I interferon (IFN-I)-induced signaling plays a critical role in host antiviral innate immune responses. Despite this, the mechanisms that regulate this pathway have yet to be fully elucidated. The nucleoporin Ran Binding Protein 2 (RanBP2) (also known as Nucleoporin 358 KDa, Nup358) has been implicated number of cellular processes, including pathways, and is influence viral infection. In study, we documented RanBP2 mediates sumoylation signal transducers activators transcription 1...
Resumption of menstrual cycles is one the indicators for restoration reproductive capability in postpartum women. However, menstruation does not necessarily mean that ovulation has taken place. The aim this study was to investigate relation supplementary feeding return and after delivery.A questionnaire used obtain data from 101 breastfeeding mothers. following elements were analyzed: age, education level, practice, time menstruation, contraceptive starting during lactation at intervals 6...
Abstract: The aim of this study was to explore sperm chromosomal aneuploidy and DNA integrity in infertile patients with spinal cord injury (SCI). Semensamples were collected from 12 menwith SCI by percutaneous vasal aspiration (PVSA) 14 male penile vibratory stimulation (PVS). These semen samples as well 16 donors analyzed using the hypo‐osmotic swelling (HOS) test, chromatin dispersion terminal deoxynucleotidyl transferase‐mediated uridine nick‐end labeling assay, multicolor fluorescence...
The purpose of this study is to explore the immunoregulatory role microRNA-21 (miR-21) targeting TLR4/MyD88 signaling pathway in macrophages response Bacillus Calmette-Guerin (BCG) infection.After infection with BCG, mouse RAW246.7 cells were assigned into control, miR-21 mimic + mimic-negative control (NC) inhibitor inhibitor-NC BCG TAK242 (an TLR4 pathway), and groups. Western blotting qRT-PCR used detect expression miR-21, MyD88. levels TNF-a, IL-6 IL-10 detected by enzyme-linked...
Abstract At present, male contraceptive methods are only vasectomy and condoms, so it is necessary to research on techniques. The aim of this study observe the effects scrotal heating (SH) semen parameters, seminal l ‐carnitine (LC), epidermal growth factor (EGF), macrophage migration inhibitory (MIF), reproductive hormones sperm chromosome numbers adult healthy men, provide experimental data for contraception. scrotums 30 volunteers were exposed condition 40 43°C SH belt warming minutes...