A5101799424- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Tracheal and airway disorders
- Mitochondrial Function and Pathology
- Esophageal and GI Pathology
- Sleep and Wakefulness Research
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Disaster Response and Management
- Esophageal Cancer Research and Treatment
- Stress Responses and Cortisol
- Whipple's Disease and Interleukins
- Safety and Risk Management
- Olfactory and Sensory Function Studies
- Genetic Neurodegenerative Diseases
- Advanced Glycation End Products research
- Traumatic Brain Injury and Neurovascular Disturbances
Xuzhou Medical College
2014-2024
Nanjing Medical University
2016-2022
Jiangsu Province Hospital
2016-2022
Army Medical University
2009-2014
Xinqiao Hospital
2009
Mounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases premature mortality later in life. One mechanistic hypothesis for this phenomenon is early life adversity alters the expression or functioning of glucocorticoid receptor (GR) throughout course thereby increases sensitivity inflammatory stimulation. An exaggerated pro-inflammatory response generally considered be a key cause postoperative cognitive dysfunction (POCD). The aim study was...
Abstract Background Postoperative cognitive dysfunction (POCD) is a common complication after anesthesia/surgery, especially among elderly patients, and poses significant threat to their postoperative quality of life overall well-being. While it widely accepted that patients may experience POCD following the exact mechanism behind this phenomenon remains unclear. Several studies have indicated interaction between silent mating type information regulation 2 homologue 1 (SIRT1) brain-derived...
Abstract Aim Repeated exposure to ketamine during the neonatal period in mice leads cognitive impairments adulthood. These are likely caused by synaptic plasticity and excitability damage. We investigated precise role of brain‐derived neurotrophic factor (BDNF) induced repeated period. Methods evaluated function using Morris water maze test novel object recognition test. Western blotting immunofluorescence were used detect protein levels BDNF. blotting, Golgi‐Cox staining, transmission...
Background: Previous studies have shown ketamine can alter the proliferation and differentiation of neural stem cells (NSCs) in vitro. However, these effects not been entirely clarified vivo subventricular zone (SVZ) neonatal rats. The present study was designed to investigate on NSCs SVZ rats vivo. Methods: Postnatal day 7 (PND-7) male Sprague-Dawley were administered four injections 40 mg/kg at 1-h intervals, then 5-bromodeoxyuridine (BrdU) injected intraperitoneally PND-7, 9 13. NSC...
Cardiac surgery with cardiopulmonary bypass (CPB) is considered to be one of the surgical types highest incidence post-operative delirium (POD). POD has been associated a prolonged intensive care and hospital stay, long-term neurocognitive deterioration, increased mortality. However, specific pathogenesis still unclear. Untargeted metabolomics techniques can used understand changes serum metabolites in early discover relationship between disease.The present study recruited 58 elderly...
Background/Aims: Ketamine is a widely used anesthetic in obstetric and pediatric anesthesia. In the developing brain, widespread neuron apoptosis triggered by ketamine has been demonstrated. However, little known about its effect on neural stem cells (NSCs) function. This study aimed to investigate of proliferation NSCs from neonatal rat hippocampus. Methods: Neural were isolated hippocampus Sprague-Dawley rats postnatal day 3. dose-response experiments, cultured exposed different...
Background: Ketamine disrupts the proliferation and differentiation of developing neural stem cells (NSCs). Therefore, safe use ketamine in pediatric anesthesia has been an issue increasing concern among anesthesiologists children's parents. Dexmedetomidine (DEX) is widely used sedation as antianxiety agent for analgesia. DEX recently shown to provide neuroprotection against anesthetic-induced neurotoxicity brain. The aim this vivo study was investigate whether exerted neuroprotective...
Abstract Background Ketamine has been reported to cause neonatal neurotoxicity in a variety of developing animal models. Various studies have conducted study the mechanism for general anesthetic use during period. Previous experiments suggested that developmentally generated granule neurons hippocampus dentate gyrus (DG) supported hippocampus-dependent memory. Therefore, this aimed investigate whether ketamine affects functional integration DG. For purpose,the postnatal day 7 (PND-7)...
Abstract Background Tracheoesophageal fistula (TEF) is a rare but life-threatening complication after esophagectomy. A new gastrointestinal occluder device provides treatment for TEF patients. However, TEF-related pneumonia and respiratory failure increase the difficulty of anesthesia management, especially in airway management. Case presentation 64-year-old man with thoracic esophageal cancer underwent esophagectomy gastric tube reconstruction one year ago. The patient presented recurrent...
Abstract The mechanism of ketamine-induced neurotoxicity development remains elusive. Mitochondrial fusion/fission dynamics play a critical role in regulating neurogenesis. Therefore, this study was aimed to evaluate whether mitochondrial were involved impairment neurogenesis neonatal rats and long-term synaptic plasticity dysfunction. In the vivo study, postnatal day 7 (PND-7) intraperitoneally injected with 40 mg/kg ketamine four consecutive times at 1 h intervals. Our work revealed that...
Abstract Background Ketamine has been reported to cause neonatal neurotoxicity in a variety of developing animal models. Various studies have conducted study the mechanism for general anesthetic use during period. Previous experiments suggested that developmentally generated granule neurons hippocampus dentate gyrus (DG) supported hippocampus-dependent memory. Therefore, this aimed investigate whether ketamine affects functional integration DG. For purpose ， postnatal day 7 (PND-7)...
Abstract Background Ketamine has been reported to cause neonatal neurotoxicity in a variety of developing animal models. Various studies have conducted study the mechanism for general anesthetic use during period. Previous experiments suggested that developmentally generated granule neurons hippocampus dentate gyrus (DG) supported hippocampus-dependent memory. Therefore, this aimed investigate whether ketamine affects functional integration DG. For purpose，the postnatal day 7 (PND-7) SD rats...
Abstract Background Ketamine has been reported to cause neonatal neurotoxicity in a variety of developing animal models. Various studies have conducted study the mechanism for general anesthetic use during period. Previous experiments suggested that developmentally generated granule neurons hippocampus dentate gyrus (DG) supported hippocampus-dependent memory. Therefore, this aimed investigate whether ketamine affects functional integration DG. For purpose，the postnatal day 7 (PND-7)...
Abstract Background Ketamine has been reported to cause neonatal neurotoxicity in a variety of developing animal models. Various studies have conducted study the mechanism for general anesthetic use during period. Previous experiments suggested that developmentally generated granule neurons hippocampus dentate gyrus (DG) supported hippocampus-dependent memory. Therefore, this aimed investigate whether ketamine affects functional integration DG. For purpose ， postnatal day 7 (PND-7)...
Abstract Background: Recent years, the number of neonatal patients receiving surgery under general anesthesia is increasing. Previous studies have indicated that ketamine can disturb proliferation and differentiation developing neural stem cells (NSCs). Therefore, safe use in pediatric has drawn great concern among anesthesiologists children’s parents. Dexmedetomidine (DEX) widely used sedation, antianxiety analgesia. shown DEX could provide neuroprotection against anesthetic-induced...