Anders Mälarstig
A5028094654- Genetic Associations and Epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Bioinformatics and Genomic Networks
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Genomics and Rare Diseases
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Genetics and Neurodevelopmental Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- Alzheimer's disease research and treatments
- Immunodeficiency and Autoimmune Disorders
- Acute Myocardial Infarction Research
- Protease and Inhibitor Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Gene expression and cancer classification
- Health, Environment, Cognitive Aging
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Folate and B Vitamins Research
- Adipose Tissue and Metabolism
Karolinska Institutet
2016-2025
Pfizer (Sweden)
2016-2025
Pfizer (United States)
2012-2025
Svenska Örtmedicinska Institute
2024
Pfizer (United Kingdom)
2012-2023
University of California, San Francisco
2017
SomaLogic (United States)
2017
National Cerebral and Cardiovascular Center
2017
Karolinska University Hospital
2008-2016
Eli Lilly (United States)
2012-2016
Abstract Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These survived the founding bottleneck rather than being distributed over large ultrarare variants. Although this effect is well established Mendelian genetics, its value common disease genetics less explored 1,2 . FinnGen aims to study genome and national health register data...
An increased level of Lp(a) lipoprotein has been identified as a risk factor for coronary artery disease that is highly heritable. The genetic determinants the and their relevance are incompletely understood.We used novel gene chip containing 48,742 single-nucleotide polymorphisms (SNPs) in 2100 candidate genes to test associations 3145 case subjects with 3352 control subjects. Replication was tested three independent populations involving 4846 additional 4594 subjects.Three chromosomal...
Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted genome-wide protein quantitative trait locus (pQTL) study 91 plasma measured using the Olink Target platform 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration pQTL data with eQTL disease association studies provided insight into pathogenesis, implicating lymphotoxin-α multiple sclerosis. Using...
OBJECTIVE Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, resistance, type 2 diabetes (T2D). Studies the processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS We have conducted meta-analysis genome-wide association tests ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) fasting in 10,701 nondiabetic adults...
ABSTRACT Population isolates such as Finland provide benefits in genetic studies because the allelic spectrum of damaging alleles any gene is often concentrated on a small number low-frequency variants (0.1% ≤ minor allele frequency < 5%), which survived founding bottleneck, opposed to being distributed over much larger ultra--rare variants. While this advantage well-- established Mendelian genetics, its value common disease genetics has been less explored. FinnGen aims study genome and...
While conventional LDL-C, HDL-C, and triglyceride measurements reflect aggregate properties of plasma lipoprotein fractions, NMR-based more accurately particle concentrations according to class (LDL, HDL, VLDL) size (small, medium, large). The these sub-fractions may be related risk cardiovascular disease metabolic disorders. We performed a genome-wide association study 17 measures determined by NMR together with triglycerides, ApoA1, ApoB in 17,296 women from the Women's Genome Health Study...
Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds plasma proteins large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved regulation protein expression plasma, and 2) determine whether are likely be causally implicated disease. We report here results genome-wide association (GWA) 83 considered relevant cardiovascular disease (CVD), measured 3,394 individuals multiple...
Inflammation, which is directly regulated by interleukin-6 (IL-6) signaling, implicated in the etiology of several chronic diseases. Although a common, non-synonymous variant IL-6 receptor gene (IL6R Asp358Ala; rs2228145 A>C) associated with risk common diseases, 358Ala allele conferring protection from coronary heart disease (CHD), rheumatoid arthritis (RA), atrial fibrillation (AF), abdominal aortic aneurysm (AAA), and increased susceptibility to asthma, variant's effect on signaling not...
To date, the development of disease-modifying therapies for Alzheimer's disease (AD) has largely focused on removal amyloid beta Aβ fragments from CNS. Proteomic profiling patient fluids may help identify novel therapeutic targets and biomarkers associated with AD pathology. Here, we applied Olink™ ProSeek immunoassay to measure 270 CSF plasma proteins across 415 Aβ- negative cognitively normal individuals (Aβ- CN), 142 Aβ-positive CN (Aβ+ 50 mild cognitive impairment (MCI) patients, 75 Aβ+...
Background— The secreted protein proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for lowering plasma low-density lipoprotein cholesterol and preventing cardiovascular disease (CVD). relationship between circulating PCSK9 incident CVD in the general population unknown. We investigated whether serum concentration associated with prospective cohort study of 4232 men women 60 years age at time recruitment. Methods Results— Incident was recorded by matching to...
A genetic contribution to preeclampsia susceptibility has been established but is still incompletely understood.To disentangle the underlying architecture of and or other maternal hypertension during pregnancy with a genome-wide association study (GWAS) hypertensive disorders pregnancy.This GWAS included meta-analyses in combination phenotype encompassing disorders. Two overlapping groups were selected for examination, namely, pregnancy. Data from Finnish Genetics Pre-eclampsia Consortium...
Abstract The human solute carrier (SLC) superfamily of ~460 membrane transporters remains the largest understudied protein family despite its therapeutic potential. To advance SLC research, we developed a comprehensive knowledgebase that integrates systematic multi-omics data sets with selected curated information from public sources. We annotated substrates through literature curation, compiled disease associations using mining techniques, and determined subcellular localization SLCs by...
Several genome-wide association studies have recently linked a group of single nucleotide polymorphisms in the 9p21 region with cardiovascular disease. The molecular mechanisms this link are not fully understood. We investigated five different expression microarray datasets order to determine if genotype had effect on any gene transcript aorta, mammary artery, carotid plaque and lymphoblastoid cells.After multiple testing correction, no genes were found relation rs2891168 risk genotype,...