A5089192575- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Adolescent and Pediatric Healthcare
- Electroconvulsive Therapy Studies
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Treatment of Major Depression
- Electrolyte and hormonal disorders
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Neuropeptides and Animal Physiology
- Suicide and Self-Harm Studies
- Amino Acid Enzymes and Metabolism
- Regulation of Appetite and Obesity
- Child and Adolescent Psychosocial and Emotional Development
- Pharmacological Receptor Mechanisms and Effects
University of Gothenburg
2016-2025
Centre for Mental Health
2024
Cardiff University
2024
Karolinska Institutet
2015-2024
Sahlgrenska University Hospital
2012-2024
Medical Research Council
2024
Blekinge Institute of Technology
2017
National University of Ireland, Maynooth
2009-2015
National Hospital for Neurology and Neurosurgery
2015
University College London
2015
Abstract Emerging evidence suggests that inflammation has a key role in depression and suicidal behavior. The kynurenine pathway is involved neuroinflammation regulates glutamate neurotransmission. In the cerebrospinal fluid (CSF) of patients, levels inflammatory cytokines metabolite quinolinic acid (QUIN), an N -methyl- d -aspartate receptor agonist, are increased. enzyme amino-β-carboxymuconate-semialdehyde-decarboxylase (ACMSD) limits QUIN formation by competitive production...
Although evidence for mitochondrial dysfunction in the pathogenesis of bipolar disorder (BD) has been reported, precise biological basis remains unknown, hampering search novel biomarkers. In this study, we performed metabolomics cerebrospinal fluid (CSF) from male BD patients (n=54) and age-matched healthy controls (n=40). Subsequently, post-mortem brain analyses, genetic CSF samples rats treated with lithium or valproic acid were also performed. After multivariate logistic regression,...
Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to association APOE with cortical Aβ deposition or whether directly influences CSF Aβ42 independently pathology remains unknown.To evaluate genotype affects diagnostic accuracy biomarkers for Alzheimer disease (AD), in particular levels, and depends on status.We collected data from 4 different centers Sweden, Finland, Germany....
Bipolar disorder (BD) is a severe and debilitating psychiatric disorder. However, the precise biological basis remains unknown, hampering search for novel biomarkers. We performed metabolomics analysis to discover peripheral biomarkers BD. quantified serum levels of 116 metabolites in mood-stabilized male BD patients (n = 54) age-matched healthy controls 39). After multivariate logistic regression, pyruvate, N-acetylglutamic acid, α-ketoglutarate, arginine were significantly higher than...
Bipolar disorder is associated with medical comorbidities that have been linked to systemic inflammatory mechanisms. There is, however, limited evidence supporting a role of neuroinflammation in bipolar disorder. Here we tested whether microglial activation and tissue remodelling processes are related by analyzing markers cerebrospinal fluid (CSF) serum from patients healthy controls.Serum was sampled euthymic controls, CSF large subset these individuals. The levels monocyte chemoattractant...
Introduction: The St. Göran Bipolar Project (SBP) is a longitudinal outpatient study investigation aimed at identifying predictive factors associated with long-term outcomes in individuals bipolar disorder. These include cognitive function, relapse rate, treatment responses, and functional outcomes. employs multifaceted approach, integrating brain imaging, biochemical analyses of cerebrospinal fluid blood, genetics. This paper aims to provide an overview the research methods used SBP, along...
Cognitive deficits have been documented in patients with bipolar disorder. Further, it has suggested that the degree and type of cognitive impairment differ between I II disorder, but data is conflicting remains inconclusive. This study aimed to clarify differences disorder a relatively large, clinically stable sample while controlling for potential confounders. 67 43 86 randomly selected population-based healthy controls were compared. A number neuropsychological tests administered,...
Abstract Objectives Large‐scale studies on phenotypic differences between bipolar disorder type I (BDI) and II (BDII) are scarce. Methods Individuals with BDI (N = 4806) BDII 3960) were compared respect to clinical features, illness course, comorbid conditions, suicidality, socioeconomic factors using data from the Swedish national quality assurance register for disorders (BipoläR). Results had higher rate of depressive episodes more frequent suicide attempts than BDI. Furthermore, group...
Many but not all persons with bipolar disorder require hospital care because of severe mood episodes. Likewise, some patients experience long-term occupational dysfunction that extends beyond acute It is known whether these dissimilar outcomes are driven by different polygenic profiles. Here, scores (PGSs) for major psychiatric disorders and educational attainment were assessed associations functioning admissions in disorder.
Randomly distributed Dictyostelium discoideum cells form cooperative territories by signaling to each other with cAMP. Cells initiate the process sending out pulsatile signals, which propagate as waves. With time, circular and spiral patterns form. We show that adding spatial temporal noise levels of an important regulator external cAMP levels, phosphodiesterase inhibitor, we can explain natural progression system from randomly firing waves whose symmetries break double- single- or...
Bipolar disorder carries a high risk of suicide. Identification factors is important. The aim this study was to for suicide in large cohort men and women with bipolar disorder.A prospective using clinical data from the Swedish National Quality Register Affective Disorder (BipoläR). outcome variable captured Cause Death between 2004 2014. Hazard ratios (HR) were calculated Cox proportional hazards models.Of 12 850 persons (4844 8006 women) disorder, 90 (55 35 died by during follow-up period...
Bipolar disorder is accompanied by cognitive impairments, which persists during euthymic phases. The purpose of the present study was to identify those neuropsychological tests that most reliably tell bipolar patients and controls apart, clarify extent these impairments are clinically significant as judged from norms.Patients with (type I: n = 64; type II: 44) (n 86) were examined a comprehensive test battery yielding 47 measures executive functioning, speed, memory, verbal skills....
The purpose of the present study was to investigate if cerebrospinal fluid (CSF) biomarkers neurodegeneration are associated with cognition in bipolar disorder and healthy controls, respectively. CSF concentrations total phosphorylated tau, amyloid beta (Aβ)1-42, ratios Aβ42/40 Aβ42/38, soluble precursor protein α β, neurofilament light chain were analyzed relation neuropsychological performance 82 euthymic patients 71 controls. Linear regression models applied account for five cognitive...
The aim was to investigate the personality profile of bipolar disorder I and II, healthy controls, study whether influences course disorder.One hundred ten patients with I, 85 86 individuals had their assessed using Swedish universities Scales Personality (SSP), an instrument developed explore personality-related vulnerabilities correlates psychiatric disorders. Patients were followed prospectively for 2 years. To assess impact Neuroticism, Aggressiveness, Disinhibition on illness course, we...
There have been reports of long-term subjective memory worsening after electroconvulsive therapy (ECT).To study the prevalence and risk factors among patients receiving ECT in routine clinical practice.Patients (n = 535, whom 277 were included final analysis) recruited from eight Swedish hospitals. Participants' impairment was assessed before a median 73 days using item Comprehensive Psychopathological Rating Scale. Participants also rated their pre-ECT expectations post-ECT evaluations...