A5066404161- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Amino Acid Enzymes and Metabolism
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Gut microbiota and health
- Bone Metabolism and Diseases
- Neurotransmitter Receptor Influence on Behavior
- Epigenetics and DNA Methylation
- Bone health and osteoporosis research
- Diet and metabolism studies
- Rare-earth and actinide compounds
- Magnetic Properties of Alloys
- Diatoms and Algae Research
- Metabolism and Genetic Disorders
- Bone health and treatments
- Pancreatic function and diabetes
- Pharmacological Receptor Mechanisms and Effects
- Marine Biology and Ecology Research
- Nicotinic Acetylcholine Receptors Study
- Chemical Synthesis and Analysis
- Reproductive System and Pregnancy
- Marine Bivalve and Aquaculture Studies
- Hormonal Regulation and Hypertension
Center for Forensic Mental Health, Chiba University
2015-2024
University of Fukui
2014-2024
Kyushu Dental University
2008-2022
Asahi Intecc (Japan)
2022
Kanazawa University
2022
Hyogo University of Health Sciences
2021
Kobe University
2021
Chiba University
2005-2020
Nagahama City Hospital
2020
Tokyo University of Agriculture and Technology
2013-2017
Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), signaling represent potential therapeutic targets for major depressive disorder. The purpose of this study is to examine whether TrkB ligands show antidepressant effects in an inflammation-induced model depression. In study, we examined the agonist 7,8-dihydroxyflavone (7,8-DHF) antagonist ANA-12 on depression-like behavior morphological changes mice previously exposed lipopolysaccharide (LPS)....
Accumulating evidence suggests that the gut microbiota-brain axis plays a role in pathogenesis of depression, thereby contributing to antidepressant actions certain compounds. (R)-ketamine has greater potency and longer-lasting effects than (S)-ketamine. Here, we investigated whether microbiota these two ketamine enantiomers. The enantiomers chronic social defeat stress (CSDS) model depression was examined using 16S ribosomal RNA gene sequencing fecal samples. At phylum level,...
Abstract Accumulating evidence suggests that abnormalities in the composition of gut microbiota may play a role pathogenesis depression. Although approximately 30% mice are resilient to chronic social defeat stress (CSDS), this resilience is unknown. In study, male C57BL/6 were exposed different CD1 aggressor mouse for 10 min on consecutive days. A interaction test was applied distinguish between and susceptible mice. Using 16S rRNA analysis, we examined feces from control, resilient, The...
Abstract Background The brain–gut–microbiota axis plays a role in the pathogenesis of stress-related disorders such as depression. In this study, we examined effects fecal microbiota transplantation (FMT) mice with antibiotic-treated depletion. Methods was obtained from subjected to chronic social defeat stress (CSDS) and control (no CSDS) mice. FMT these two groups performed 16S rRNA analysis examine composition gut microbiota. Furthermore, subdiaphragmatic vagotomy depression-like...
Significance Maternal exposure to high levels of the herbicide glyphosate may increase risk for autism spectrum disorder (ASD) in offspring; however, underlying mechanisms remain largely unknown. during pregnancy and lactation caused ASD-like behavioral abnormalities abnormal composition gut microbiota murine male offspring. Soluble epoxide hydrolase (sEH) brain offspring after maternal was higher than controls. Treatment with an sEH inhibitor from weaning prevented onset exposure. The...
Abstract In rodent models of depression, ( R )-ketamine has greater potency and longer-lasting antidepressant effects than S )-ketamine; however, the precise molecular mechanisms underlying actions remain unknown. Using RNA-sequencing analysis, we identified novel targets that contribute to different two enantiomers. Either (10 mg/kg) or was administered susceptible mice after chronic social defeat stress (CSDS). analysis prefrontal cortex (PFC) subsequent GSEA (gene set enrichment analysis)...
The relationship between high-fat food consumption and obesity is well-established. However, it as yet unclear whether diet (HFD)-induced in childhood adolescence determines age-related changes jaw bone health. aim of this study to examine the influence HFD-induced on mandibular architecture structure periodontium growing mice. Male C57BL/6 J mice (6-weeks-old) were divided into two groups (n = 6 each): control group received a experimental HFD. After treatment for 4, 8, or 12 weeks,...
Abstract Increasing evidence indicates that abnormalities in the composition of gut microbiota might play a role stress-related disorders. In learned helplessness (LH) paradigm, ~60–70% rats are susceptible to LH face inescapable electric stress. The susceptibility paradigm is unknown. this study, male were exposed stress under paradigm. compositions and short-chain fatty acids assessed fecal samples from control rats, non-LH (resilient) (susceptible) rats. Members order Lactobacillales...
Lectins on antigen presenting cells are potentially involved in the uptake and cellular recognition trafficking. Serial analysis of gene expression monocyte-derived dendritic (DCs), monocytes, macrophages revealed that 7 19 C-type lectin mRNA were present immature DCs. Two these, macrophage mannose receptor specific for galactose/N-acetylgalactosamine (MGL), found only DCs, as confirmed by reverse transcriptase-PCR flow cytometric analysis. By subcloning sequencing amplified mRNA, we...
Background Since the discovery of deep-sea chemosynthesis-based communities, much work has been done to clarify their organismal and environmental aspects. However, major topics remain be resolved, including when how organisms invade adapt environments; whether strategies for invasion adaptation are shared by different taxa or unique each taxon; extend distribution diversity; they become isolated speciate in continuous waters. Deep-sea mussels one dominant thus investigations origin...
Oxidative stress and inflammation play a role in cognitive impairment, which is core symptom of schizophrenia. Furthermore, hallmark the pathophysiology this disease dysfunction cortical inhibitory γ-aminobutyric acid (GABA) neurons expressing parvalbumin (PV), also involved impairment. Sulforaphane (SFN), an isothiocyanate derived from broccoli, potent activator transcription factor Nrf2, plays central inducible expressions many cytoprotective genes response to oxidative stress. Keap1...
Point mutations in the vacuolar protein sorting 35 gene (VPS35) have been associated with an autosomal dominant form of late-onset Parkinson disease (PARK17), but there has considerable debate over whether it is caused by a loss- or gain-of-function mechanism and intracellular target site neurotoxicity. To investigate pathogenesis PARK17 vivo, we generated Vps35 D620N knock-in (KI) mice, expressing homologous mutant endogenous patterns expression, simultaneously deletion 1 (Del1) which carry...
Betaine is known to act against various biological stresses and its levels were reported be decreased in schizophrenia patients. We aimed test the role of betaine pathophysiology, evaluate potential as a novel psychotherapeutic.Using Chdh (a gene for synthesis)-deficient mice betaine-supplemented inbred mice, we assessed psychiatric psychotherapeutic, by leveraging metabolomics, behavioral-, transcriptomics DNA methylation analyses.The Chdh-deficient revealed remnants behaviors along with...
(R, S)-ketamine has prophylactic antidepressant-like effects in rodents; however, the precise molecular mechanisms underlying its action remain unknown. Using RNA-sequencing analysis, we searched novel target(s) that contribute to of (R)-ketamine, a more potent enantiomer S)-ketamine. Pretreatment with (R)-ketamine (10 mg/kg, 6 days before) significantly ameliorated body weight loss, splenomegaly, and increased immobility time forced swimming test lipopolysaccharide (LPS: 1.0 mg/kg)-treated...