A5039904568- Tryptophan and brain disorders
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Stress Responses and Cortisol
- Treatment of Major Depression
- Gut microbiota and health
- Vasculitis and related conditions
- Gout, Hyperuricemia, Uric Acid
- Neuroscience and Neuropharmacology Research
- Heme Oxygenase-1 and Carbon Monoxide
- Pluripotent Stem Cells Research
- Extracellular vesicles in disease
- Genetic and Kidney Cyst Diseases
- Pharmacological Effects of Natural Compounds
- Biomedical Ethics and Regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Wnt/β-catenin signaling in development and cancer
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Axon Guidance and Neuronal Signaling
- Case Reports on Hematomas
- CRISPR and Genetic Engineering
- Sepsis Diagnosis and Treatment
- Medicinal Plants and Bioactive Compounds
Nanfang Hospital
2019-2025
Southern Medical University
2019-2025
Guangdong Provincial People's Hospital
2025
West China Hospital of Sichuan University
2019-2024
Sichuan University
2019-2024
Hebei Medical University
2022-2024
Cell Technology (China)
2024
Center for Forensic Mental Health, Chiba University
2015-2023
University of Pittsburgh
2023
National Clinical Research
2022
Although the efficacy of racemate ketamine, a rapid onset and sustained antidepressant, for patients with treatment-resistant depression was serendipitous finding, clinical use ketamine is limited, due to psychotomimetic side effects abuse liability. Behavioral side-effect evaluation tests were applied compare two stereoisomers ketamine. To elucidate their potential therapeutic mechanisms, we examined these on brain-derived neurotrophic factor (BDNF)-TrkB signaling, synaptogenesis in...
Sepsis is defined as end-organ dysfunction resulting from the host's inflammatory response to infection. One of most common sepsis-injured organs kidneys, in acute kidney injury (AKI) that contributes high morbidity and mortality, especially patients intensive care unit. Fisetin, a naturally occurring flavonoid, has been reported protect against rat lipopolysaccharide (LPS)-induced lung injury. However, effect fisetin on septic AKI remains unknown.The current study proposed systematically...
Accumulating evidence suggests that the gut microbiota-brain axis plays a role in pathogenesis of depression, thereby contributing to antidepressant actions certain compounds. (R)-ketamine has greater potency and longer-lasting effects than (S)-ketamine. Here, we investigated whether microbiota these two ketamine enantiomers. The enantiomers chronic social defeat stress (CSDS) model depression was examined using 16S ribosomal RNA gene sequencing fecal samples. At phylum level,...
Abstract Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis chronic kidney diseases. As Klotho is large transmembrane it challenging to harness as therapeutic remedy. Here we report discovery Klotho-derived peptide 1 (KP1) protecting kidneys by targeting TGF-β signaling. By screening series peptides derived from human identified KP1 that repressed fibroblast activation binding receptor 2 (TβR2) and disrupting TGF-β/TβR2 engagement. such, blocked TGF-β-induced...
Abstract Depression is a common, severe and chronic psychiatric disease. Although the currently available antidepressants have been used in treatment of depression, their beneficial effects are limited. Accumulating evidence suggests that pro-inflammatory cytokines such as interleukin-6 (IL-6) an important role pathogenesis depression. This study was undertaken to examine whether anti-mouse IL-6 receptor antibody (MR16-1) induces antidepressant social defeat stress model. Intravenous...
Brain-derived neurotrophic factor (BDNF) has a role in the pathophysiology of psychiatric disorders. The precursor proBDNF is converted to mature BDNF and pro-peptide, N-terminal fragment proBDNF; however, precise function these proteins disorders unknown. We sought determine whether expression altered brain peripheral tissues from patients with measured protein proBDNF, pro-peptide parietal cortex, cerebellum, liver spleen control, major depressive disorder (MDD), schizophrenia (SZ) bipolar...
Significance Parkinson’s disease (PD) is a chronic and progressive movement disorder; however, the precise mechanisms of its etiology remain largely unknown. Soluble epoxide hydrolase (sEH) plays key role in inflammation associated with PD pathogenesis. The sEH inhibitor or deletion gene protected against MPTP-induced neurotoxicity mouse brain. Furthermore, expression protein (or mRNA) was higher striatum MPTP-treated mice, patients dementia Lewy bodies (DLB), neurons from iPSCs patient...
Accumulating evidence suggests a key role of the gut-microbiota-brain axis in antidepressant actions certain compounds. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, showed rapid and sustained effects treatment-resistant depressed patients. In contrast, another NMDAR lanicemine, did not exhibit such (R)-ketamine, (R)-enantiomer ketamine, has rapid-acting long-lasting rodent models depression. Here we compared (R)-ketamine lanicemine on depression-like phenotype composition...
Abstract Sepsis is a systemic inflammatory state in response to infection, and concomitant acute kidney injury (AKI) significantly increases morbidity mortality. Growing evidence suggests that fatty acid-binding protein 4 (FABP4) critically involved diseases, while its role septic AKI remains unknown. Here, FABP4 was mainly upregulated renal tubular epithelial cells (RTECs) following cecal ligation puncture (CLP)- or lipopolysaccharide (LPS)-induced AKI. inhibition by genetic deletion...
Abstract Depression is a core symptom of methamphetamine (METH) withdrawal during the first several weeks abstinence. However, precise mechanisms underlying METH symptoms remain unknown. Brain-derived neurotrophic factor (BDNF) and its specific receptor, tropomyosin-related kinase (TrkB), have role in pathophysiology depression. In this study, we examined BDNF–TrkB signaling different brain regions male mice with symptoms. Repeated (3 mg kg −1 per day for 5 days) administration to caused...
The intestinal flora serves a critical role in the development of hyperuricemia-induced chronic kidney disease (CKD). We previously found that natural flavonol fisetin exhibited nephroprotective effects hyperuricemic mice. However, mechanism remains largely unknown. To investigate underlying fisetin, mice were fed with potassium oxonate and adenine to introduce CKD. Fisetin improved function, ameliorated renal fibrosis, restored enteric dysbacteriosis CKD Meanwhile, gut microbiota-derived...
Natural flavonoid pectolinarigenin (PEC) was reported to alleviate tubulointerstitial fibrosis of unilateral ureteral obstruction (UUO) mice in our previous study. To further investigate nephroprotective effects PEC hyperuricemic nephropathy (HN), adenine and potassium oxonate induced HN uric acid-treated mouse kidney epithelial (TCMK-1) cells were employed the As a result, significantly lowered serum acid level restored hyperuricemia-related injury mice. Meanwhile, alleviated inflammation,...
Acute kidney injury (AKI) is a common and lethal complication for inpatients in the intensive care unit. Accumulative evidence suggests that severe inflammation oxidative stress are major causes of AKI. Natural polyphenols with potent antioxidative anti-inflammation activities promising treatment AKI, but low bioavailability reduces their therapeutic efficacy vivo. Herein, we reported novel polyphenol-based nanomedicine comprising tea polyphenol nanocarrier insoluble small-molecule drug...
Abstract Acute kidney injury (AKI) is one of the serious clinical syndromes with high morbidity and mortality. Despite substantial progress in understanding mechanism AKI, no effective drug available for treatment or prevention. In this study, we identified that a ligand-activated transcription factor aryl hydrocarbon receptor (AhR) was abnormally increased kidneys cisplatin-induced AKI mice tubular epithelial TCMK-1 cells. The AhR inhibition by BAY2416964 conditional deletion both...
Abstract Podocyte injury is a hallmark of glomerular diseases; however, the underlying mechanisms remain unclear. B7-1 increased in injured podocytes, but its intrinsic role controversial. The clinical data here revealed intimate correlation urinary with severity injury. Through transcriptomic and biological assays transgenic adriamycin nephropathy models, we identified key mediator podocyte glomerulosclerosis through series signal transmission to β-catenin. Using LC-MS/MS, Hsp90ab1,...
Increasing evidence suggested that gut microbiota played critical roles in developing autoimmune diseases. This study investigated the correlation between and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) with kidney injury. We analyzed fecal samples of 23 AAV patients injury using a 16s RNA microbial profiling approach. The alpha-diversity indexes were significantly lower than healthy controls (Sobs P < 0.001, Shannon Chao 0.001). beta-diversity difference demonstrated...
Abstract Kidney fibrosis, characterized by the activation and expansion of matrix-producing fibroblasts, is common outcome chronic kidney disease (CKD). While fibroblast proliferation well studied in CKD, little known about regulation mechanism depletion. Here, we show that exosomes derived from stressed/injured tubules play a pivotal role dictating apoptosis fate. When human tubular cells (HK-2) were stimulated with TGF-β1, they produced released increased amounts (TGFβ-Exo), which...
Kidney fibrosis is characterized by excessive accumulation of extracellular matrix (ECM) and serves as a hallmark chronic kidney disease (CKD). The turnover ECM controlled family metalloproteinases (MMPs), endopeptidases that play crucial role in remodeling other cellular processes. In this study, we demonstrate MMP-10 was upregulated variety animal models human biopsies from CKD patients. Bioinformatics analyses experimental validation reveal activated β-catenin Wnt-independent fashion....
Abstract Accumulating evidence suggests a role of the ephrin receptor EphA4 and downstream protein ephexin1 in synaptic plasticity, which is implicated depression. We examined whether EphA4–ephexin1 signaling plays pathophysiology depression, antidepressant-like effect inhibitor rhynchophylline. found increased ratios p-EphA4/EphA4 p-ephexin1/ephexin1 prefrontal cortex (PFC) hippocampus but not nucleus accumbens (NAc), susceptible mice after social defeat stress. Furthermore, ratio was...
Abstract Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase involved in regulating wide range of biologic processes, such as apoptosis, cell proliferation, and tissue remodeling. However, the role MMP-10 pathogenesis acute kidney injury (AKI) unknown. In this study, we show that was upregulated kidneys predominantly localized tubular epithelium various models AKI induced by ischemia/reperfusion (IR) or cisplatin. Overexpression exogenous ameliorated AKI, manifested...