A5084593654- Tryptophan and brain disorders
- Treatment of Major Depression
- Stress Responses and Cortisol
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Nerve injury and regeneration
- Adipose Tissue and Metabolism
- Acute Myeloid Leukemia Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Autophagy in Disease and Therapy
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- Immune Cell Function and Interaction
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Virus-based gene therapy research
- Ferroptosis and cancer prognosis
Capital Medical University
2015-2025
Nanjing Medical University
2014-2025
Jiangsu Province Hospital
2019-2025
Hainan Center for Disease Control & Prevention
2025
Shandong University
2025
Chongqing Medical University
2016-2025
Jiangsu University
2025
Affiliated Hospital of Jiangsu University
2025
Beijing Anzhen Hospital
2025
Soochow University
2015-2024
Proinflammatory cytokines have been shown to impair cognition; consequently, immune activity in the central nervous system was considered detrimental cognitive function. Unexpectedly, however, T cells were recently support learning and memory, though underlying mechanism unclear. We show that one of steps cascade cell-based memory takes place meningeal spaces. Performance tasks led accumulation IL-4-producing meninges. Depletion from spaces skewed myeloid toward a proinflammatory phenotype....
Although the efficacy of racemate ketamine, a rapid onset and sustained antidepressant, for patients with treatment-resistant depression was serendipitous finding, clinical use ketamine is limited, due to psychotomimetic side effects abuse liability. Behavioral side-effect evaluation tests were applied compare two stereoisomers ketamine. To elucidate their potential therapeutic mechanisms, we examined these on brain-derived neurotrophic factor (BDNF)-TrkB signaling, synaptogenesis in...
Abstract Ketamine exerts fast acting, robust, and lasting antidepressant effects in a sub-anesthetic dose, however, the underlying mechanisms are still not fully elucidated. Recent studies have suggested that ketamine's probably attributed to activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. The present study aimed observe AMPA receptor modulators on mammalian target rapamycin (mTOR) brain-derived neurotrophic factor (BDNF) expression during procedure...
Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), signaling represent potential therapeutic targets for major depressive disorder. The purpose of this study is to examine whether TrkB ligands show antidepressant effects in an inflammation-induced model depression. In study, we examined the agonist 7,8-dihydroxyflavone (7,8-DHF) antagonist ANA-12 on depression-like behavior morphological changes mice previously exposed lipopolysaccharide (LPS)....
The role of the mechanistic target rapamycin (mTOR) signaling in antidepressant effects ketamine is controversial. In addition to mTOR, extracellular signal-regulated kinase (ERK) a key molecule prominent pathways that regulate protein synthesis. (R)-Ketamine has greater potency and longer-lasting than (S)-ketamine. Here we investigated whether mTOR ERK play two enantiomers.The inhibitors (rapamycin AZD8055) an inhibitor (SL327) on enantiomers chronic social defeat stress (CSDS) model (n = 7...
Accumulating evidence suggests that the gut microbiota-brain axis plays a role in pathogenesis of depression, thereby contributing to antidepressant actions certain compounds. (R)-ketamine has greater potency and longer-lasting effects than (S)-ketamine. Here, we investigated whether microbiota these two ketamine enantiomers. The enantiomers chronic social defeat stress (CSDS) model depression was examined using 16S ribosomal RNA gene sequencing fecal samples. At phylum level,...
Abstract Accumulating evidence suggests that abnormalities in the composition of gut microbiota may play a role pathogenesis depression. Although approximately 30% mice are resilient to chronic social defeat stress (CSDS), this resilience is unknown. In study, male C57BL/6 were exposed different CD1 aggressor mouse for 10 min on consecutive days. A interaction test was applied distinguish between and susceptible mice. Using 16S rRNA analysis, we examined feces from control, resilient, The...
Abstract ( R,S )-ketamine elicits rapid-acting and sustained antidepressant actions in treatment-resistant patients with depression. R produces longer-lasting effects than S rodents; however, the precise molecular mechanisms underlying of remain unknown. Using isobaric Tag for Relative Absolute Quantification, we identified nuclear receptor-binding protein 1 (NRBP1) that could contribute to different antidepressant-like two enantiomers chronic social defeat stress (CSDS) model. NRBP1 was...
Abstract Patients with chronic neuropathic pain frequently suffer from symptoms of anhedonia, which is a core symptom depression. Accumulating studies suggest that gut microbiota may play role in depression via gut–microbiota–brain axis. However, it unknown whether plays pain-associated anhedonia. Here, we used rat model spared nerve injury (SNI). Hierarchical cluster analysis sucrose preference test (SPT) results was to classify the SNI rats or without anhedonia-like phenotype. The 16S...
Abstract Pain and anxiety comorbidities are a common health problem, but the neural mechanisms underlying comorbidity remain unclear. We propose that implies similar brain regions circuits, with lateral septum (LS) as major candidate, process pain anxiety. From results of behavioral neurophysiological experiments combined selective LS manipulation in mice, we find GABAergic neurons were critical for both Selective activation induced hyperalgesia anxiety-like behaviors. In contrast,...
Introduction. Previous studies have shown that a single sub-anesthetic dose of ketamine exerts fast-acting antidepressant effects in patients and animal models depression. However, the underlying mechanisms are not totally understood. This study aims to investigate acute administration different doses on immobility time rats forced swimming test (FST) determine levels hippocampal brain-derived neurotrophic factor (BDNF) mammalian target rapamycin (mTOR). Methods. Forty male Wistar weighing...
Alzheimer's disease is characterized by cognitive dysfunction and aging an important predisposing factor; however, the pathological therapeutic mechanisms are not fully understood. Recently, role of gut microbiota in has received increasing attention. The function senescence-accelerated mouse prone 8 (SAMP8) mice was significantly decreased Chao 1 Shannon indices, principal coordinates analysis, component analysis results were notably abnormal compared with that those resistant (SAMR1) mice....
Abstract The transcription factor Keap1-Nrf2 system plays a key role in inflammation which is involved depression. We found lower expression of Keap1 and Nrf2 proteins the prefrontal cortex (PFC), CA3 dentate gyrus (DG) hippocampus mice with depression-like phenotype compared to control mice. Serum levels pro-inflammatory cytokines knock-out (KO) were higher than those wild-type mice, suggestive enhanced KO Decreased brain-derived neurotrophic (BDNF) its receptor tropomyosin-receptor-kinase...
Depression is a severe and chronic psychiatric disease, affecting 350 million subjects worldwide. Although multiple antidepressants have been used in the treatment of depressive symptoms, their beneficial effects are limited. The soluble epoxide hydrolase (sEH) plays key role inflammation that involved depression. Thus, we examined here sEH In both social defeat stress models depression, potent inhibitor, TPPU, displayed rapid antidepressant effects. Expression protein brain from chronically...
Accumulating evidence suggests a key role of the gut-microbiota-brain axis in antidepressant actions certain compounds. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, showed rapid and sustained effects treatment-resistant depressed patients. In contrast, another NMDAR lanicemine, did not exhibit such (R)-ketamine, (R)-enantiomer ketamine, has rapid-acting long-lasting rodent models depression. Here we compared (R)-ketamine lanicemine on depression-like phenotype composition...