A5102023404- Ionosphere and magnetosphere dynamics
- Solar and Space Plasma Dynamics
- Geomagnetism and Paleomagnetism Studies
- Earthquake Detection and Analysis
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Astro and Planetary Science
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Genomics, phytochemicals, and oxidative stress
- Nuclear Receptors and Signaling
- Seismic Waves and Analysis
- Nicotinic Acetylcholine Receptors Study
- GNSS positioning and interference
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Amino Acid Enzymes and Metabolism
- Axon Guidance and Neuronal Signaling
- Neurotransmitter Receptor Influence on Behavior
- Cholinesterase and Neurodegenerative Diseases
- Atmospheric Ozone and Climate
- Neurogenesis and neuroplasticity mechanisms
- Biochemical and Structural Characterization
Shandong First Medical University
2025
Center for Forensic Mental Health, Chiba University
2010-2023
University of New Hampshire at Manchester
2015-2022
Jinan University
2020-2022
Emory University
2020-2021
University of New Hampshire
2009-2019
Taisho Pharmaceutical (Japan)
2016
Chiba University
2011
Rice University
2007-2009
University of Michigan
2004-2007
Abstract We perform a statistical study of electromagnetic ion cyclotron (EMIC) waves detected by the Van Allen Probes mission to investigate spatial distribution their occurrence, wave power, ellipticity, and normal angle. The have been used which allow us explore inner magnetosphere (1.1 5.8 R E ). Magnetic field measurements from Electric Field Instrument Suite Integrated Science on board are identify EMIC events for first 22 months operation (8 September 2012 30 June 2014). examined in H...
Abstract To improve our understanding of the role electromagnetic ion cyclotron (EMIC) waves in radiation belt electron dynamics, we perform a comprehensive analysis EMIC wave‐induced resonant scattering outer zone relativistic (>0.5 MeV) electrons and resultant loss time scales with respect to wave band, L shell, normal angle model. The results demonstrate that while H + ‐band dominate losses ~1–4 MeV electrons, it is He O prevail over pitch diffusion ultrarelativistic at higher...
Receptors have a prominent role in brain function, as they are the effector sites of neurotransmission at postsynaptic membrane, regulatory on presynaptic for transmitter reuptake and feedback, modulating various functions cell membrane. Distribution, density, activity receptors can be visualized by radioligands labeled SPECT PET, receptor binding quantified appropriate tracer kinetic models, which modified simplified particular application. Selective available systems, distribution these...
Abstract Electromagnetic ion cyclotron (EMIC) waves are an important mechanism for particle energization and losses inside the magnetosphere. In order to better understand effects of these on dynamics, detailed information about occurrence rate, wave power, ellipticity, normal angle, energy propagation angle distributions, local plasma parameters required. Previous statistical studies have used in situ observations investigate distribution magnetic time versus L‐shell (MLT‐L) frame within a...
This paper presents a focused review of the role entropy in plasma sheet transport and also describes new calculations implications conservation for case where pressure is not isotropic. For isotropic case, varies proportion to log[ PV 5/3 ], P V volume tube containing one unit magnetic flux. Theory indicates that should be conserved ideal MHD approximation, generalized form holds when by gradient/curvature drift included. These considerations lead conclusion under assumption strong, elastic...
Similar to the N-methyl-D-aspartate receptor antagonist ketamine, metabotropic glutamate 2/3 antagonist, MGS0039, shows antidepressant effects. However, there are no reports comparing these 2 compounds in social defeat stress model of depression. We examined effects MGS0039 (1 mg/kg) and ketamine (10 on depression-like behavior susceptible mice after repeated stress. Protein levels brain-derived neurotrophic factor, TrkB, phospho-TrkB, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid...
Parkinson's disease (PD) is the second most common neurodegenerative disease. Pathologically, PD characterized by formation of Lewy bodies (LBs) in brain, which mainly comprises phosphorylated and aggregated α-synuclein (α-syn). The aberrant aggregation α-syn believed to play a key role pathogenesis PD. While expression can be reduced antisense oligonucleotides (ASOs), challenge deliver ASOs safely effectively into neurons remains unresolved. Here, we developed safe highly effective ASO...
In the learned helplessness (LH) paradigm, approximately 35% of rats are resilient to inescapable stress.The roles brain-derived neurotrophic factor (BDNF) and dendritic spine density in brain regions LH (susceptible) non-LH (resilient) were examined. Western blot analysis Golgi staining performed.BDNF levels medial prefrontal cortex, CA3, dentate gyrus (DG) significantly lower group than control groups, whereas BDNF nucleus accumbens (NAc) but not higher those group. Furthermore, prelimbic...
Abstract A statistical examination on the spatial distributions of electromagnetic ion cyclotron (EMIC) waves observed by Van Allen Probes against varying levels geomagnetic activity (i.e., AE and SYM‐H ) dynamic pressure has been performed. Measurements taken Electric Magnetic Field Instrument Suite Integrated Science for first full magnetic local time (MLT) precession (September 2012–June 2014) are used to identify over 700 EMIC wave events. Spatial found vary depending level solar wind...
The N-methyl-d-aspartate (NMDA) receptor antagonists, including R-ketamine and rapastinel (formerly GLYX-13), show rapid antidepressant effects in animal models of depression. We compared the sustained social defeat stress model. In tail suspension forced swimming tests, (10 mg/kg, intraperitoneal (i.p.)) or i.p.) significantly attenuated increased immobility time susceptible mice, with vehicle-treated group. sucrose preference test, both compounds enhanced reduced mice 2, 4, 7 days after a...
Addition of low doses atypical antipsychotic drugs with selective serotonin reuptake inhibitors (SSRIs) could promote a rapid antidepressant effect in treatment-resistant patients major depression. Brexpiprazole, new drug, has been used as adjunctive therapy for the treatment
Ionospheric origin O + accelerated in the cusp/cleft region convects over polar cap and flows along open field lines to tail lobes. Some lobes enters near‐Earth plasma sheet where it is then convected inner magnetosphere, while some ends up distant lost. In order understand transport of ionospheric so as its contribution formation geomagnetic storms, we have determined occurrence frequency cusp source caps determine when observed. The results show that probability observing path high even...
Abstract We report the wave observations, associated plasma measurements, and linear theory testing of electromagnetic ion cyclotron (EMIC) events observed by Van Allen Probes on 28 April 2013. The are detected in their generation regions as three individual two consecutive orbits Probe‐A, while other spacecraft, B, does not detect any significant EMIC activity during this period. Three overlapping H + populations around plasmapause when waves excited. difference between observational growth...
Abstract The α7 subtype of nicotinic acetylcholine receptor (nAChR) plays a role in the inflammation which is implicated depression. This study was undertaken to examine nAChR depression using knock-out (KO) mice. Serum levels tumor necrosis factor-α and interlukin-1β KO mice were higher than wild-type mice, suggesting an inflammatory process showed depression-like phenotype. Furthermore, increased brain-derived neurotrophic factor (BDNF) its TrkB signaling, as well synaptogenesis spine...
Abstract Addition of low doses the atypical antipsychotic drug brexpiprazole with selective serotonin reuptake inhibitors (SSRIs) could promote antidepressant effect in patients major depressive disorder although precise mechanisms underlying action combination are unknown. Combination dose (0.1 mg/kg) and SSRI fluoxetine (10 a rapid social defeat stress model or alone did not show effect. Furthermore, significantly improved alterations brain-derived neurotrophic factor (BDNF) - TrkB...
Abstract This is the second in a pair of papers discussing statistical study electromagnetic ion cyclotron (EMIC) waves detected during 10 years (2001–2010) Cluster observations. In first paper, an analysis EMIC wave properties (i.e., power, polarization, normal angle, and propagation angle) presented both magnetic latitude (MLAT)‐distance as well local time (MLT)‐L frames. paper focuses on distribution wave‐associated plasma conditions two generation proxies (the electron frequency to...
Abstract Prenatal infection and subsequent abnormal neurodevelopment of offspring is involved in the etiology schizophrenia. Brain-derived neurotrophic factor (BDNF) its high affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role neurodevelopment. Pregnant mice exposed to polyriboinosinic-polyribocytidylic acid [poly(I:C)] causes schizophrenia-like behavioral abnormalities their at adulthood. Here we found that juvenile poly(I:C)-treated showed cognitive deficits,...
Using the Dst value corrected for effects of magnetopause currents ( *) and solar wind magnetic field plasma data from 1 January 1998 to 30 April 2002, during elevated conditions, we have statistically examined relationship 271 storms * ≤ −30 nT) 104 clouds. It is found that most clouds result in geomagnetic storms, but only about 30% are due A storm can be driven by a cloud's various regions or their combinations with dissimilar occurrence percentages. These percentages change as function...
On December 4, 2004, the COmposition and DIstribution Function (CODIF) Analyzer on board Cluster spacecraft observed a prolonged He + energization event from 06:00 to 10:30 UT. In this paper, we perform case study of by using in situ plasma magnetic field measurements Double Star Program (DSP) Tan Ce 1 (TC1) spacecraft. event, ions were energized up keV. The ion heating was associated with three consecutive EMIC waves, which occurred near dusk‐side magnetospheric flank, L = 13.1–14.5, region...
Accumulating evidence suggests that inflammation plays a role in the pathophysiology of major depression. The adenosine triphosphate (ATP)-sensitive P2X7 receptor (P2X7R) crucial microglial activation caused by inflammation. dye brilliant blue G (BBG) is P2X7R antagonist. This study examined whether BBG shows antidepressant effects an inflammation-induced model We (12.5, 25, or 50 mg/kg) on serum tumor necrosis factor-α (TNF-α) levels after administering bacterial endotoxin...