A5101715995- DNA Repair Mechanisms
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
- COVID-19 and Mental Health
- Ubiquitin and proteasome pathways
- SARS-CoV-2 and COVID-19 Research
- Microtubule and mitosis dynamics
- Esophageal Cancer Research and Treatment
- RNA Research and Splicing
- Cancer-related gene regulation
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects and Toxicity Studies
- Gastroesophageal reflux and treatments
- Infection Control and Ventilation
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Epilepsy research and treatment
- Colorectal Cancer Screening and Detection
- Wnt/β-catenin signaling in development and cancer
- Dialysis and Renal Disease Management
- Ferroptosis and cancer prognosis
- Respiratory viral infections research
Xiangya Hospital Central South University
2025
Central South University
2025
Mayo Clinic in Arizona
2018-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2020-2024
University of Electronic Science and Technology of China
2022-2024
Xuzhou Medical College
2024
Lianyungang Oriental Hospital
2024
Mayo Clinic
2018-2023
Renmin Hospital of Wuhan University
2011-2021
Wuhan University
2011-2021
Protein acetylation modification plays important roles in various aspects of tumor progression. Ferroptosis driven by lethal lipid peroxidation is closely related to development. Targeting ferroptosis has become a promising strategy. However, the crosstalk between protein and remains unclear. In present study, we found that acyl-CoA synthase long-chain family member 4 (ACSL4) enhances its stability double-edged sword regulation nasopharyngeal carcinoma (NPC). On one hand, ACSL4 could promote...
Triple-negative breast cancer (TNBC) is characterized by elevated locoregional recurrence risk despite aggressive local therapies. New tumor-specific radiosensitizers are needed. We hypothesized that the ATR inhibitor, VX-970 (now known as M6620), would preferentially radiosensitize TNBC. Noncancerous epithelial and TNBC cell lines were investigated in clonogenic survival, cycle, DNA damage signaling repair assays. In addition, patient-derived xenograft (PDX) models generated prospectively...
Abstract Since December 2019, more than 79,000 people have been diagnosed with infection of the Corona Virus Disease 2019 (COVID-19). A large number medical staff were dispersed for Wuhan city and Hubei province to aid COVID-19 control. Psychological stress, especially vicarious traumatization (VT) caused by pandemic, should not be ignored. To address this concern, study employed a total 214 general public (GP) 526 nurses evaluate VT scores via mobile app-based questionnaire. Results showed...
Abstract Homologous recombination (HR) is important for error-free DNA double strand break repair and maintenance of genomic stability. However, upregulated HR also used by cancer cells to promote therapeutic resistance. Therefore, inducing deficiency (HRD) a viable strategy sensitize proficient cancers targeted therapies in order overcome A bromodomain containing protein, BRD9, was previously reported regulate chromatin remodeling transcription. Here, we discover that following damage, the...
Background and Aim: The global pandemic of COVID-19 has posed an enormous threat to the economy people's lives across various countries. Patients with most commonly present respiratory symptoms. However, gastrointestinal (GI) symptoms can also occur. We aimed study relationship between GI disease prognosis in patients COVID-19. Methods: In a single-center retrospective cohort study, outcomes or without were compared. propensity score is conditional probability having particular exposure...
Abstract The RNA-sensing pathway contributes to type I interferon (IFN) production induced by DNA damaging agents. However, the potential involvement of RNA sensors in repair is unknown. Here, we found that retinoic acid-inducible gene (RIG-I), a key cytosolic sensor recognizes virus and initiates MAVS-IRF3-type IFN signaling cascade, recruited double-stranded breaks (DSBs) suppresses non-homologous end joining (NHEJ). Mechanistically, RIG-I interacts with XRCC4, RIG-I/XRCC4 interaction...
Abstract Proton Bragg peak irradiation has a higher ionizing density than conventional photon or the entrance of proton beam profile. Whether targeting DNA damage response (DDR) could enhance vulnerability to distinct pattern induced by is currently unknown. Here, we performed genetic pharmacologic manipulation key DDR elements and evaluated signaling, repair, tumor control in cell lines xenografts treated with same physical dose across radiotherapy linear energy transfer spectrum....
Abstract Triple-negative breast cancer (TNBC) treatment remains a great challenge for clinical practice and novel therapeutic strategies are urgently needed. UCHL3 is deubiquitinase that overexpressed in TNBC correlates with poor prognosis. deubiquitinates RAD51 thereby promoting the recruitment of to DNA damage sites augmenting repair. Therefore, overexpression can render cells resistant inducing chemo radiotherapy, targeting sensitize radiation chemotherapy. However, small molecule...