A5036250927- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Bipolar Disorder and Treatment
- Cerebrovascular and genetic disorders
- Functional Brain Connectivity Studies
- Neurological Disorders and Treatments
- Frailty in Older Adults
- Blood Pressure and Hypertension Studies
- Schizophrenia research and treatment
- Genetics and Neurodevelopmental Disorders
- Adolescent and Pediatric Healthcare
- Delphi Technique in Research
- Health Systems, Economic Evaluations, Quality of Life
- Older Adults Driving Studies
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Genetic Associations and Epidemiology
- Spatial Neglect and Hemispheric Dysfunction
- Health, Environment, Cognitive Aging
- Traditional Chinese Medicine Studies
- Aging and Gerontology Research
- Stress Responses and Cortisol
- Electroconvulsive Therapy Studies
- Neurological disorders and treatments
University of Gothenburg
2012-2023
AstraZeneca (United Kingdom)
2011
Cognitive-enhancing effects of vagus nerve stimulation (VNS) have been reported during 6 months treatment in a pilot study patients with Alzheimer's disease (AD). Data through 1 year VNS (collected from June 2000 to September 2003) are now reported.All (N = 17) met the National Institute Neurological and Communicative Disorders Stroke Disease Related Association (NINCDS-ADRDA) criteria for probable AD. Responder rates Assessment Scale-cognitive subscale (ADAS-cog) Mini-Mental State...
Objective: To examine the independent contributions and combined interactions of medial temporal lobe atrophy (MTA), cortical subcortical atrophy, white matter lesion (WML) volume in longitudinal cognitive performance. Methods: A total 477 subjects with age-related WML were evaluated brain MRI annual neuropsychological examinations 3-year follow-up. Baseline determinants decline analyzed linear mixed models controlling for multiple confounders. Results: MTA predicted significantly steeper...
This study examines the intra-individual stability of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) over 2 years in 83 patients with mild cognitive impairment (MCI) and 17 cognitively healthy control individuals. All participants underwent clinical neuropsychological evaluation lumbar puncture at baseline after a university hospital memory clinic. CSF was analyzed total tau (T-tau), phospho-tau(181) (P-tau(181)) amyloid-beta(1-42) (Abeta(1-42)). During 2-year...
<h3>Objective</h3> The objective was to study the 2-year outcome of subjects diagnosed as having mild cognitive impairment (MCI). <h3>Methods</h3> Two hundred and nine MCI were examined with a comprehensive neuropsychological test battery followed up after 2 years. <h3>Results</h3> After years, 34 (16%) lost for follow-up. Those did not differ significantly in terms subclassification, MMSE score or age education. Of 175 up, eight (4.5%) had improved normal, two amnestic MCI, one from...
Cerebrospinal fluid (CSF) measurements of amyloid-β42 (Aβ42 ), total-tau (T-tau), and phosphorylated tau (P-tau) may be used to predict future Alzheimer's disease (AD) dementia in patients with mild cognitive impairment (MCI). The precise temporal de
This study examined whether the cognitive profile of subjects with mild impairment (MCI) vascular disease differs from that MCI no disease. Consecutive (n=60) and matched were included in compared healthy control (n=60). The neuropsychological assessment comprised tests speed attention, episodic memory, visuospatial function, language, executive function. Control performed significantly better than did both groups on battery. overall disease, most clearly without exhibited differences, terms...
Abstract Objective Cerebral white‐matter changes (WMCs) are frequently found in dementia and have been proposed to be related vascular factors a certain symptomatological profile. However, few studies included both broad spectrum of cognitive, neurological psychiatric symptoms, easily detectable by the physician everyday clinical work. The objective was study relationships between WMCs on MRI/CT neuropsychiatric symptoms patients with cognitive impairment. Methods One hundred seventy‐six...
The aim of this study was to predict cognitive performance on the basis cerebrospinal fluid (CSF) biomarkers total tau (T-tau) and amyloid-β42 (Aβ42 ) in controls patients at various impairment levels. Previous studies have found an associ
The purpose of the present study was to investigate if cerebrospinal fluid (CSF) biomarkers neurodegeneration are associated with cognition in bipolar disorder and healthy controls, respectively. CSF concentrations total phosphorylated tau, amyloid beta (Aβ)1-42, ratios Aβ42/40 Aβ42/38, soluble precursor protein α β, neurofilament light chain were analyzed relation neuropsychological performance 82 euthymic patients 71 controls. Linear regression models applied account for five cognitive...
Abstract Introduction Subjective cognitive decline (SCD) and biomarker‐based “at‐risk” concepts such as “preclinical” Alzheimer's disease (AD) have been developed to predict AD dementia before objective impairment is detectable. We longitudinally evaluated outcome when using these classifications. Methods Memory clinic patients ( n = 235) were classified SCD 122): subtle 36) mild 77) subsequently subclassified into SCDplus National Institute on Aging–Alzheimer's Association (NIA‐AA) stages 0...
Mild cognitive impairment (MCI) is regarded as the prodromal stage of dementia disorders, such Alzheimer's disease (AD). Objective: To compare neuropsychological profiles MCI subjects with normal concentrations total tau (T-τ) and Aβ42 in CSF (MCI-norm) to deviating biomarkers (MCI-dev). MCI-norm ( N = 73) MCI-dev were compared controls 50) on tests speed/attention, memory, visuospatial function, language executive function. Results: performed overall better than MCI-dev, specifically speed...
<i>Objective:</i> To study which cognitive profiles of incipient dementia strongest predict the conversion to Alzheimer’s disease (AD) and mixed (MD)/vascular (VaD). <i>Methods:</i> 260 subjects with mild impairment (MCI) were included in 209 (79%) followed up after 2 years. At baseline, assessed a neuropsychological battery covering domains speed/attention, memory, visuospatial, language executive functions. <i>Results:</i> After years, 9 considered...
Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies.The aim of study was to assess whether baseline CSF hyperphosphorylated tau (P-tau), total (T-tau), amyloid beta 1-42 (Abeta(42)) and neurofilament light (NF-L) in patients with could predict subcortical vascular dementia (SVD) Alzheimer's disease (AD) at follow-up.Biomarker levels were assessed by Luminex...
<i>Background:</i> Mild cognitive impairment (MCI) is a heterogeneous condition suggested as prodromal state of Alzheimer’s disease (AD) and subcortical vascular dementia (SVD). Recent findings suggest that white matter lesions (WML) may be associated with hippocampal atrophy. The objective the study was to examine WML volumes in MCI patients if were linked <i>Methods:</i> Gothenburg clinically based longitudinal biennial clinical assessments. participants (n = 166)...
Objective Frontal cortical abnormalities and executive function impairment co‐occur in bipolar disorder. Recent studies have shown that subtypes differ the degree of structural functional impairments. The relationships between cognitive performance integrity not been clarified might across patients with disorder type I, II , healthy subjects. Method Using a vertex‐wise whole‐brain analysis, we investigated how integrity, as measured by thickness, correlates controls ( N = 160). Results We...
The ability to predict future decline in cognitive systems using the cerebrospinal fluid (CSF) biomarkers 42 amino acid form of amyloid-β (Aβ42 ) and total tau (T-tau) is not fully understood. In a clinical sample ranging from cognitively healthy
<i>Background: </i>The concept of the cognitive reserve (CR) posits that factors such as education enable compensation for effect brain pathology. Consequently, pathology should be more pronounced in individuals with higher CR before becoming clinically apparent. Biomarkers total tau (t-tau) and β-amyloid 42 (Aβ42) may surrogates relation to patients neurodegenerative disease. <i>Objective:</i> To examine applicability biomarkers mild impairment (MCI) either...
Objectives LIM homeobox transcription factor 1, alpha ( LMX 1A ) and neuregulin 1 NRG are susceptibility genes for schizophrenia that have been implicated in the dopaminergic pathway associated with altered cognitive functioning. We hypothesized single nucleotide polymorphisms SNP s) would be functioning bipolar disorder. Methods In total, four s were directly genotyped. Regression models five aggregated domains intelligence quotient IQ score run using risk variants of (rs11809911,...
Abstract Introduction Previous research on structural changes in early‐onset Alzheimer's disease (EOAD) and late‐onset (LOAD) have reported inconsistent findings. Methods In the present substudy of Gothenburg MCI study, 1.5 T scans were used to estimate lobar hippocampal volumes using FreeSurfer. Study participants (N = 145) included 63 patients with AD, (24 EOAD [aged ≤65 years], 39 LOAD >65 years]), 25 healthy controls aged years, 57 years. Results Hippocampal atrophy is most prominent...