Ana Verdelho
A5076932119- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Aging, Elder Care, and Social Issues
- Cerebrovascular and genetic disorders
- Prion Diseases and Protein Misfolding
- Functional Brain Connectivity Studies
- Trace Elements in Health
- Iron Metabolism and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Healthcare Systems and Practices
- Health, Medicine and Society
- Neurogenetic and Muscular Disorders Research
- Neurological diseases and metabolism
- Stroke Rehabilitation and Recovery
- Health Systems, Economic Evaluations, Quality of Life
- Cerebrospinal fluid and hydrocephalus
- Cognitive Abilities and Testing
- Neurological disorders and treatments
Hospital de Santa Maria
2014-2024
University of Lisbon
2015-2024
University of Coimbra
2018-2024
Centro Hospitalar Lisboa Norte
2016-2024
Instituto de Saúde
2019-2024
Lusíada University of Lisbon
2024
IPO Porto
2017-2024
Centro Hospitalar do Porto
2023
Hospitais da Universidade de Coimbra
2019-2023
Instituto de Medicina Tropical
2023
Abstract The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct trajectories. Here we introduce machine-learning technique—Subtype Stage Inference (SuStaIn)—able uncover data-driven with temporal progression patterns, from widely available cross-sectional patient studies. Results imaging studies in two reveal subgroups their trajectories regional...
Abstract Introduction Progress in understanding and management of vascular cognitive impairment (VCI) has been hampered by lack consensus on diagnosis, reflecting the use multiple different assessment protocols. A large multinational group clinicians researchers participated a two‐phase Vascular Impairment Cognition Classification Consensus Study (VICCCS) to agree principles (VICCCS‐1) protocols (VICCCS‐2) for diagnosis VCI. We present VICCCS‐2. Methods used VICCCS‐1 published diagnostic...
Abstract Introduction Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none been universally accepted. These not readily comparable, impacting on rates turn prevalence estimates, research, treatment. Methods The Vascular Impairment Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries an online Delphi consensus study....
Background and Purpose- Cerebral small vessel disease is characterized by a wide range of focal global brain changes. We used magnetic resonance imaging segmentation tool to quantify multiple types disease-related changes examined their individual combined predictive value on cognitive functional abilities. Methods- Magnetic scans 560 older individuals from LADIS (Leukoaraiosis Disability Study) were analyzed using automated atlas- convolutional neural network-based methods yielding...
The optimal management of post-stroke cognitive impairment (PSCI) remains controversial. These joint European Stroke Organisation (ESO) and Academy Neurology (EAN) guidelines provide evidence-based recommendations to assist clinicians in decision making regarding prevention, diagnosis, treatment prognosis.Guidelines were developed according the Grading Recommendations, Assessment, Development Evaluation (GRADE) methodology. working group identified relevant clinical questions, performed...
On cerebral magnetic resonance imaging (MRI), white matter hyperintensities (WMH) and lacunes are generally viewed as evidence of small vessel disease. The clinical significance disease in terms global cognitive function has yet not been completely clarified. We investigated the independent contribution WMH to general a group independently living elderly with varying degrees disease.Data were drawn from multicenter, multinational Leukokraurosis Disability (LADIS) study. There 633...
<i>Background:</i> Cross-sectional studies have indicated that subcortical ischemic vascular disease (SIVD), as defined according to imaging criteria, is associated with a specific clinical and cognitive profile. Much less known about the long-term consequences of SIVD. The aim study was investigate longitudinal performance incident dementia in subjects without SIVD sample older adults white matter lesions. <i>Methods:</i> In Leukoaraiosis Disability (LADIS) study,...
In cerebral small vessel disease, the core MRI findings include white matter lesions (WML) and lacunar infarcts. While clinical significance of WML is better understood, contribution lacunes to rate cognitive decline has not been established. This study investigated whether incident on determine longitudinal change in elderly subjects with WML.Within Leukoaraiosis Disability Study (LADIS), 387 were evaluated repeated neuropsychological assessment at baseline after 3 years. Predictors global...
<b>Objective:</b> We aimed to study if age-related white matter changes (WMC) and vascular risk factors were predictors of cognitive decline in elderly subjects with WMC living independently. <b>Methods:</b> The Leukoaraiosis Disability prospective multinational European (LADIS) evaluates the impact on transition independent into disability. Independent enrolled due presence WMC. Subjects evaluated yearly during 3 years a comprehensive clinical protocol neuropsychological battery....
Frontotemporal dementia (FTD) is a highly heritable condition with multiple genetic causes. In this study, similarities and differences of gray matter (GM) atrophy patterns were assessed among 3 common forms FTD (mutations in C9orf72, GRN, MAPT). Participants from the Genetic Initiative (GENFI) cohort suitable volumetric T1 magnetic resonance imaging scan included (319): 144 nonmutation carriers, 128 presymptomatic mutation 47 clinically affected carriers. Cross-sectional GM volume between...
<h3>Background and purpose:</h3> Age related white matter changes (ARWMC) are frequent in non-demented old subjects associated with impaired cognitive function. Our aim was to study the influence of vascular risk factors ARWMC on neuropsychological performance an independent elderly population, see if impair cognition addition effects ARWMC. <h3>Methods:</h3> Independent subjects, aged 65–84 years, any degree were assessed using a comprehensive battery including Mini-Mental State Examination...
Objective: To examine the independent contributions and combined interactions of medial temporal lobe atrophy (MTA), cortical subcortical atrophy, white matter lesion (WML) volume in longitudinal cognitive performance. Methods: A total 477 subjects with age-related WML were evaluated brain MRI annual neuropsychological examinations 3-year follow-up. Baseline determinants decline analyzed linear mixed models controlling for multiple confounders. Results: MTA predicted significantly steeper...
We aimed to study if physical activity could interfere with progression for cognitive impairment and dementia in older people white matter changes living independently.The LADIS (Leukoaraiosis Disability) prospective multinational European evaluates the impact of on transition independent elderly subjects into disability. Subjects were evaluated yearly during 3 years a comprehensive clinical protocol assessment classification according usual criteria. Physical was recorded interview. MRI...
The optimal management of post-stroke cognitive impairment remains controversial. These joint European Stroke Organisation (ESO) and Academy Neurology (EAN) guidelines provide evidence-based recommendations to assist clinicians in decision making around prevention, diagnosis, treatment prognosis. were developed according ESO standard operating procedure the Grading Recommendations, Assessment, Development Evaluation (GRADE) methodology. working group identified relevant clinical questions,...
<b><i>Objective:</i></b> To determine frequency, determinants, and time course of poststroke depressive symptoms (DS) their relationship with dementia. <b><i>Methods:</i></b> Two hundred two consecutive stroke patients were prospectively evaluated for DS, followed up over a 3-year period. Patients Montgomery Asberg Depression Rating Scale (MADRS) scores ≥7 considered as having DS. The severity the neurologic deficit, functional outcome, dementia quantified Orgogozo Scale, modified Rankin...
<h3>Objectives:</h3> In cerebral small vessel disease, white-matter hyperintensities (WMH) and lacunes are both related to cognition. Still, their respective contribution in older people remains unclear. The purpose of this study is assess the topographic distribution determine whether it has an impact on cognitive functions a sample non-disabled patients with age-related changes. <h3>Methods:</h3> Data were drawn from baseline evaluation LADIS (Leucoaraioisis Disability study) cohort...
The mechanisms by which leukoariosis impacts on clinical and cognitive functions are not yet fully understood. We hypothesized that ultrastructural abnormalities of the normal-appearing brain tissue (NABT) assessed diffusion-weighted imaging played a major independent role.In addition to comprehensive clinical, neuropsychologic, work-up, was performed in 340 participants multicenter disability study examining impact white matter hyperintensities (WMH) 65- 85-year old individuals without...
Background and Purpose— White matter lesion (WML) progression has been advocated as a surrogate marker in intervention trials on cerebral small vessel disease. We assessed the rate of visually rated WML progression, studied correlations between cognition, estimated sample sizes for clinical with pure vs combined progression-cognitive outcomes. Methods— Those 394 participants Leukoaraiosis Disability Study (LADIS) study magnetic resonance imaging scanning at baseline 3-year follow-up were...
<h3>Objective</h3> Depressive symptoms (DS) have been associated with increased risk of cognitive decline. Our aim was to evaluate the longitudinal influence DS on cognition in independent older people, accounting for severity white matter changes (WMC). <h3>Methods</h3> The LADIS (Leukoaraiosis And DISability elderly) prospective study evaluated impact WMC transition subjects into disability. Subjects were annually over a 3 year period comprehensive clinical and neuropsychological...
Genetic frontotemporal dementia is most commonly caused by mutations in the progranulin (GRN), microtubule-associated protein tau (MAPT) and chromosome 9 open reading frame 72 (C9orf72) genes. Previous small studies have reported presence of cerebral white matter hyperintensities (WMH) genetic FTD but this has not been systematically studied across different mutations. In study WMH were assessed 180 participants from Initiative (GENFI) with 3D T1- T2-weighed magnetic resonance images: 43...