Sebastian May-Wilson
A5018237743- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Synthesis and Biological Activity
- Adipose Tissue and Metabolism
- Sensory Analysis and Statistical Methods
- Obesity, Physical Activity, Diet
- Asthma and respiratory diseases
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Genetics and Neurodevelopmental Disorders
- Protein Kinase Regulation and GTPase Signaling
- Genetic Mapping and Diversity in Plants and Animals
- Neonatal Respiratory Health Research
- Lipid metabolism and disorders
- Nutrition, Genetics, and Disease
- Olfactory and Sensory Function Studies
University of Edinburgh
2019-2024
Cancer Research UK Scotland Institute
2020-2023
Centre for Global Health Research
2019-2022
Institute of Cancer Research
2017
Abstract We present the results of a GWAS food liking conducted on 161,625 participants from UK-Biobank. Liking was assessed over 139 specific foods using 9-point scale. Genetic correlations coupled with structural equation modelling identified multi-level hierarchical map food-liking three main dimensions: “Highly-palatable”, “Acquired” and “Low-caloric”. The Highly-palatable dimension is genetically uncorrelated other two, suggesting that independent processes underlie high reward foods....
Abstract KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, significantly less potent in cancer. Using Kras-mutant mouse models mouse- patient-derived organoids, we demonstrate that KRAS with G12D mutation fundamentally rewires translation increase both bulk mRNA-specific initiation. This occurs via the MNK/eIF4E pathway culminating sustained expression c-MYC. By genetic...
Background: Lung function is highly heritable and differs between the sexes throughout life. However, little known about sex-differential genetic effects on lung function. We aimed to conduct first genome-wide genotype-by-sex interaction study identify that differ males females. Methods: tested for interactions 7,745,864 variants sex spirometry-based measures of in UK Biobank (N=303,612), sought replication 75,696 independent individuals from SpiroMeta consortium. Results: Five...
Abstract Genetically predicted levels of multi-omic traits can uncover the molecular underpinnings common phenotypes in a highly efficient manner. Here, we utilised large cohort (INTERVAL; N=50,000 participants) with extensive data for plasma proteomics (SomaScan, N=3,175; Olink, N=4,822), metabolomics (Metabolon HD4, N=8,153), serum (Nightingale, N=37,359), and whole blood Illumina RNA sequencing (N=4,136). We used machine learning to train genetic scores 17,227 traits, including 10,521...
Abstract Lung function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry GWAS meta-analysis of lung to date, comprising 580,869 participants, 1020 independent association signals identified 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age smoking groups, collectively as genetic risk...
Abstract Variable preferences for different foods are among the main determinants of their intake and influenced by many factors, including genetics. Despite considerable twins’ heritability, studies aimed at uncovering food-liking genetics have focused mostly on taste receptors. Here, we present first results a large-scale genome-wide association study food liking conducted 161,625 participants from UK Biobank. Liking was assessed over 139 specific using 9-point hedonic scale. After...
<ns4:p><ns4:bold>Background: </ns4:bold>Lung function is highly heritable and differs between the sexes throughout life. However, little known about sex-differential genetic effects on lung function. We aimed to conduct first genome-wide genotype-by-sex interaction study identify that differ males females.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> tested for interactions 7,745,864 variants sex spirometry-based measures of in UK Biobank (N=303,612), sought replication 75,696 independent...
A lack of physical activity (PA) is one the most pressing health issues today. Our individual propensity for PA influenced by genetic factors. Stated liking different types may help capture additional and informative dimensions behavior genetics.In over 157,000 individuals from UK Biobank, we performed genome-wide association studies five items assessing types, plus an derived trait overall PA-liking. We attempted to replicate significant associations in Netherlands Twin Register (NTR)...
Understanding the genetic basis of neuro-related proteins is essential for dissecting disease etiology neuropsychiatric disorders and other complex traits diseases. Here, SCALLOP Consortium conducted a genome-wide association meta-analysis over 12,500 individuals 184 in human plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) 166 trans-pQTL. mapped pQTL capture on average 50% each protein’s heritability. Mendelian randomization analyses revealed...
<title>Abstract</title> Understanding the genetic basis of neuro-related proteins is essential for dissecting molecular human behavioral traits and disease etiology neuropsychiatric disorders. Here, SCALLOP Consortium conducted a genome-wide association meta-analysis over 12,500 individuals 184 in plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) 166 trans-pQTL. mapped pQTL capture on average 50% each protein's heritability. Mendelian randomization...
<div>Abstract<p><i>KRAS</i>-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, significantly less potent in <i>KRAS</i>-mutant cancer. Using <i>Kras</i>-mutant mouse models mouse- patient-derived organoids, we demonstrate that KRAS with G12D mutation fundamentally rewires translation increase both bulk mRNA-specific initiation....
<div>Abstract<p><i>KRAS</i>-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, significantly less potent in <i>KRAS</i>-mutant cancer. Using <i>Kras</i>-mutant mouse models mouse- patient-derived organoids, we demonstrate that KRAS with G12D mutation fundamentally rewires translation increase both bulk mRNA-specific initiation....
<p>All supplemental figures and legends</p>
<p>All supplemental figures and legends</p>
Abstract Adult lung function is highly heritable and 279 genetic loci were recently reported as associated with spirometry-based measures of function. Though development differ between males females throughout life, there has been no genome-wide study to identify variants differential effects on in females. Here, we present the first genotype-by-sex interaction four traits 303,612 participants from UK Biobank. We detected five SNPs showing significant (P<5 × 10 −8 ) interactions sex...
ABSTRACT A lack of physical activity (PA) is one the most pressing health issues facing society today. Our individual propensity for PA partly influenced by genetic factors. Stated liking various behaviors may capture additional dimensions behavior that are not captured other measures, and contribute to our understanding genetics behavior. Here, in over 157,000 individuals from UK Biobank, we sought complement extend previous findings on performing genome-wide association studies...