A5073623122- Genetic Associations and Epidemiology
- Lipoproteins and Cardiovascular Health
- Diabetes Management and Research
- Blood Pressure and Hypertension Studies
- Cancer, Lipids, and Metabolism
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Obesity, Physical Activity, Diet
- Neurogenetic and Muscular Disorders Research
- Kruppel-like factors research
- Diabetes Management and Education
- Genetic Syndromes and Imprinting
- Cardiovascular Health and Disease Prevention
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lipid metabolism and disorders
- Diabetes and associated disorders
- Educational Methods and Media Use
- Hemodynamic Monitoring and Therapy
- Diabetes Treatment and Management
- Diet and metabolism studies
- Reading and Literacy Development
- Birth, Development, and Health
- Heart Rate Variability and Autonomic Control
- Genetic Mapping and Diversity in Plants and Animals
- Nutrition, Genetics, and Disease
Phoenix VA Health Care System
2022-2023
University of Arizona
2019-2022
Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease. ALS determined by gene-environment interactions and improved understanding of these may lead to effective personalised medicine. The role physical exercise in the development currently controversial.First, we dissected exercise-ALS relationship series two-sample Mendelian randomisation (MR) experiments. Next tested for enrichment genetic risk within exercise-associated transcriptome changes. Finally,...
Although hyperlipidemia is traditionally considered a risk factor for type 2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL cholesterol (LDL-C) increases T2D risk. We thus sought to more comprehensively examine the phenotypic genotypic relationships of LDL-C with T2D. Using data UK Biobank, we found levels circulating were negatively associated prevalence (odds ratio 0.41 [95% CI 0.39, 0.43] per mmol/L unit LDL-C), despite...
OBJECTIVE To determine the benefit of starting continuous glucose monitoring (CGM) in adult-onset type 1 diabetes (T1D) and 2 (T2D) with regard to longer-term control serious clinical events. RESEARCH DESIGN AND METHODS A retrospective observational cohort study within Veterans Affairs Health Care System was used compare hypoglycemia- or hyperglycemia-related admission an emergency room hospital all-cause hospitalization between propensity score overlap weighted initiators CGM nonusers over...
Background: Although use of continuous glucose monitoring (CGM) has been linked with improved control, including reductions in hemoglobin A1c and episodes hypoglycemia, there little investigation its possible role reducing other serious clinical events. Objective: To estimate the effect starting CGM patients type 2 diabetes (T2D) on mortality. Research Design: A cohort study comparing mortality between propensity score-matched users non-CGM over 18 months. Setting: Veterans Affairs Health...
ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease. ALS determined by gene-environment interactions and improved understanding of these may lead to effective personalised medicine. The role physical exercise in the development currently controversial. Methods We dissected exercise-ALS relationship series two-sample Mendelian randomisation (MR) experiments. then we tested for enrichment genetic risk within exercise-associated transcriptome...
A lack of physical activity (PA) is one the most pressing health issues today. Our individual propensity for PA influenced by genetic factors. Stated liking different types may help capture additional and informative dimensions behavior genetics.In over 157,000 individuals from UK Biobank, we performed genome-wide association studies five items assessing types, plus an derived trait overall PA-liking. We attempted to replicate significant associations in Netherlands Twin Register (NTR)...
<p> </p> <p><strong>Objective: </strong>To determine the benefit of starting continuous glucose monitoring (CGM) in adult-onset type 1 diabetes and 2 (T1D; T2D) on longer-term control serious clinical events.</p> <p><strong>Research Design Methods: </strong>A retrospective observational cohort study within VA Health Care System was used to compare control, hypoglycemia hyperglycemia related admissions emergency rooms or hospitals...
Abstract Although hyperlipidemia is traditionally considered a risk factor for type-2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL-C increases T2D risk. We thus sought to comprehensively examine the phenotypic genotypic relationships of with T2D. Using data UK Biobank, we found was negatively associated (OR=0.43[0.41, 0.45] per mmol/L unit LDL-C), despite positive associations HbA1c BMI. then performed first genome-wide...
Previous studies indicate that visit-to-visit blood pressure variability (BPv), independent of mean level, is associated with adverse cardiovascular outcomes and mortality.1-3 These findings have included cohorts both without diabetes. In a recent meta-analysis patients type 2 diabetes (T2D), significant 12% increase in all-cause mortality was linked to systolic BPv.4 A more body literature suggests associations between BPv risk nonfatal may be influenced by baseline level. For example,...
<p> </p> <p><strong>Objective: </strong>To determine the benefit of starting continuous glucose monitoring (CGM) in adult-onset type 1 diabetes and 2 (T1D; T2D) on longer-term control serious clinical events.</p> <p><strong>Research Design Methods: </strong>A retrospective observational cohort study within VA Health Care System was used to compare control, hypoglycemia hyperglycemia related admissions emergency rooms or hospitals...
Although hyperlipidemia is traditionally considered a risk factor for type-2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL-C increases T2D risk. We thus sought to more comprehensively examine the phenotypic genotypic relationships of with T2D. Using data UK Biobank, we found levels circulating were negatively associated prevalence (OR=0.41[0.39, 0.43] per mmol/L unit LDL-C), despite positive associations HbA1c BMI. then...
Although hyperlipidemia is traditionally considered a risk factor for type-2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL-C increases T2D risk. We thus sought to more comprehensively examine the phenotypic genotypic relationships of with T2D. Using data UK Biobank, we found levels circulating were negatively associated prevalence (OR=0.41[0.39, 0.43] per mmol/L unit LDL-C), despite positive associations HbA1c BMI. then...
ABSTRACT A lack of physical activity (PA) is one the most pressing health issues facing society today. Our individual propensity for PA partly influenced by genetic factors. Stated liking various behaviors may capture additional dimensions behavior that are not captured other measures, and contribute to our understanding genetics behavior. Here, in over 157,000 individuals from UK Biobank, we sought complement extend previous findings on performing genome-wide association studies...
Abstract Background and Aims Cardiometabolic disorders (CMD) arise from a constellation of features such as increased adiposity, hyperlipidemia, hypertension compromised glucose control. Many genetic loci have shown associations with individual CMD-related traits, but no investigations focused on simultaneously identifying showing across all domains. We therefore sought to identify associated risk seven continuous traits. Methods Results conducted separate genome-wide association studies...