A5116337579- Genetic Associations and Epidemiology
- Obesity, Physical Activity, Diet
- Pulmonary Hypertension Research and Treatments
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Cardiac electrophysiology and arrhythmias
- Renal and related cancers
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Lipoproteins and Cardiovascular Health
- Bacterial Identification and Susceptibility Testing
- Genetic Syndromes and Imprinting
- Renal cell carcinoma treatment
- Kruppel-like factors research
- Diversity and Career in Medicine
- Smart Systems and Machine Learning
- Biliary and Gastrointestinal Fistulas
- Brain Tumor Detection and Classification
- Medical Education and Admissions
- Actinomycetales infections and treatment
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
- DNA and Biological Computing
- Skin Protection and Aging
- Health, Environment, Cognitive Aging
University of Arizona
2016-2025
Post Graduate Institute of Medical Education and Research
2024
Galgotias University
2024
Arizona State University
2023
Government of India
2022
Norfolk and Norwich University Hospital
2022
Andover Eye Associates
2014
Although hyperlipidemia is traditionally considered a risk factor for type 2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL cholesterol (LDL-C) increases T2D risk. We thus sought to more comprehensively examine the phenotypic genotypic relationships of LDL-C with T2D. Using data UK Biobank, we found levels circulating were negatively associated prevalence (odds ratio 0.41 [95% CI 0.39, 0.43] per mmol/L unit LDL-C), despite...
Background Inflammation and dysregulated immunity are important in the development of pulmonary arterial hypertension (PAH). Compelling preclinical data supports therapeutic blockade interleukin-6 (IL-6) signalling. Methods We conducted a phase 2 open-label study intravenous tocilizumab (8 mg·kg −1 ) over 6 months patients with group 1 PAH. Co-primary end-points were safety, defined by incidence severity adverse events, change vascular resistance. Separately, mendelian randomisation was...
Differences in obesity and body fat distribution across gender race/ethnicity have been extensively described. We sought to replicate these differences evaluate newly emerging data from the All of Us Research Program (AoU). compared mass index (BMI), waist circumference, waist-to-hip ratio baseline physical examination, alanine aminotransferase (ALT) electronic health record up 88,195 Non-Hispanic White (NHW), 40,770 Black (NHB), 35,640 Hispanic, 5,648 Asian participants. AoU...
A recent genome-wide association study (GWAS) in African descent populations identified novel loci associated with skin pigmentation. However, how genomic variations affect pigmentation and these gene variants serum 25(OH) vitamin D variation has not been explored Americans (AAs). In order to further understand genetic factors that human 25(OH)D variation, we performed a GWAS for 395 AAs replication 681 AAs. Then, tested if the are concentrations subset of (n = 591). Skin pigmentation,...
Results from recent intervention trials indicated that supplemental β-carotene enhances lung cancer incidence and mortality among smokers. It was hypothesized exerting its deleterious effects through a prooxidant effect in the smoke-exposed lung. To test this hypothesis we examined interactions of cigarette smoke transformed human bronchial epithelial cells. We studied supplementation on rates gas phase smoke-induced lipid peroxidation, membrane damage depletion endogenous antioxidants...
Elevated plasma triglyceride (TG) levels are an established risk factor for type-2 diabetes (T2D). However, recent studies have hinted at the possibility that genetic TG may paradoxically protect against T2D. In this study, we examined association of with incident T2D, and interaction baseline on T2D in 13,247 European-Americans (EA) 3,238 African-Americans (AA) from three prospective cohort studies. A score (GRS) was calculated based 31 validated single nucleotide polymorphisms (SNPs). We...
Physical activity (PA), including sedentary behavior, is associated with many diseases, Alzheimer's disease and all-cause dementia. However, the specific biological mechanisms through which PA protects against are not entirely understood. To address this knowledge gap, we first assessed conventional observational associations of three self-reported device-based measures circulating levels 2,911 plasma proteins measured in UK Biobank (n max =39,160) functional enrichment identified proteins....
The identification of anaerobes, Mycobacterium and Nocardia species, moulds by MALDI-TOF-MS remains a challenge. This study aimed to evaluate the performance MALDI-TOF in these organisms.
Clear cell renal carcinoma (ccRCC) is the most prevalent subtype of kidney cancer, yet molecular biomarkers have not been used for prognosis ccRCC to aide clinical decision making. This study aimed identify genes associated with aggressiveness and overall survival (OS). Samples tumor tissue were obtained from 33 patients who underwent nephrectomy. Gene expression was determined using whole-transcriptome sequencing. The Cancer Genome Atlas Kidney Renal Cell Carcinoma (TCGA-KIRC) RNA-seq data...
Over 80% of African-American (AA) women are overweight or obese. A large racial disparity between AA and European-Americans (EA) in obesity rates exists among women, but curiously not men. Although socio-economic and/or cultural factors may partly account for this race-by-sex interaction, the potential involvement genetic has yet been investigated. Among 2,814 self-identified Atherosclerosis Risk Communities study, we estimated each individual's degree West-African ancestry using 3,437...
Background— Several studies suggest that some triglyceride-associated single-nucleotide polymorphisms (SNPs) have pleiotropic and opposite effects on glycemic traits. This potentially implicates them in pathways such as de novo lipogenesis, which is presumably upregulated the context of insulin resistance. We therefore tested whether association SNPs with triglyceride levels differs according to one’s level Methods Results— In 3 cohort (combined n=12 487), we interaction established...
Abstract The All of Us Research Program was designed to enable broad-based precision medicine research in a cohort unprecedented scale and diversity. Hypertension (HTN) is major public health concern. validity HTN data definition hypertension cases the (AoU) for use rule-based algorithms unknown. In this cross-sectional, population-based study, we compare prevalence AoU 2015–2016 National Health Nutrition Examination Survey (NHANES). We used baseline from patient (age ≥ 18) measurements...
Heart rate variability (HRV) analysis has emerged as a widely utilized, non-invasive technique for evaluating the regulation of cardiac autonomic system. Due to intricate nature cardiovascular system, it cannot be accurately characterized by time or frequency domain alone. The non-stationary these signals necessitates adoption time-frequency methodologies that can capture and characterize temporal changes in components, enabling more comprehensive understanding heart variability. In this...
Most of the symptoms coronavirus disease 2019 (COVID-19) are covered by large repertory rubrics and hence many remedies have been proposed as "genus epidemicus". The aim this study was to combine information from various data collections prepare a COVID-19 Bayesian mini-repertory/an algorithm-based application (app) test it. In July 2021, 1,161 cases 100 practitioners globally were combined. These used calculate "condition-confined" likelihood ratios (LRs) for 59 COVID-19. Out these, 35 11...