A5056935196- Nutrition and Health in Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Rheumatoid Arthritis Research and Therapies
- Aortic Disease and Treatment Approaches
- Frailty in Older Adults
- Bone health and osteoporosis research
- Nutritional Studies and Diet
- Diabetes Treatment and Management
- Dementia and Cognitive Impairment Research
- Diabetes Management and Education
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Chronic Disease Management Strategies
- Diabetes Management and Research
- Cardiac Structural Anomalies and Repair
- Silicon Carbide Semiconductor Technologies
- Systemic Lupus Erythematosus Research
- Cardiac Valve Diseases and Treatments
- Bone health and treatments
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Vitamin D Research Studies
- Health Systems, Economic Evaluations, Quality of Life
Nagoya University
2016-2025
Juntendo University
1998-2025
Mie University
1995-2024
Hokushin General Hospital
2024
Gunma Chuo Hospital
2024
Tokyo Metropolitan Institute of Gerontology
1982-2023
Tokai National Higher Education and Research System
2023
Tokyo Gakugei University
2021-2023
Japan Racing Association
2018-2023
Society of Thoracic Surgeons
2022
Conventionally, “elderly” has been defined as a chronological age of 65 years old or older, while those from through 74 are referred to “early elderly” and over 75 “late elderly.” However, the evidence on which this definition is based unknown. We have attempted review elderly by analyzing data long‐term longitudinal epidemiological studies, clinical pathological studies that accumulated at Tokyo Metropolitan Geriatric Hospital Institute Gerontology. Our recommendation might be starting...
Coronary collateral vessels reduce damage to ischemic myocardium after coronary obstruction. Factors that stimulate formation are expected have ameliorating effects on myocardial infarction. In a canine experimental infarct model, intracoronary injection of basic fibroblast growth factor (bFGF) improved cardiac systolic function and reduced size. Treatment with bFGF increased the number arterioles capillaries in infarct. Thus, angiogenic action might lead reduction The application bring...
In addition, people aged over 90 years can be classified as oldest-old or super-old. This definition mainly takes into consideration the aging situation of developed countries, but we believe that if extension life expectancy and "rejuvenation" phenomenon spreads globally, it is a concept will globally accepted. contrast, with global expectancy, appropriate to think those who have surpassed average oldest-old/super-old according previous definition. The significance re-examining...
Background: Evidence regarding the primary prevention of coronary artery disease events by low-density lipoprotein cholesterol (LDL-C) lowering therapy in older individuals, aged ≥75 years, is insufficient. This trial tested whether LDL-C–lowering with ezetimibe useful for cardiovascular patients. Methods: multicenter, prospective, randomized, open-label, blinded end-point evaluation conducted at 363 medical institutions Japan examined preventive efficacy patients elevated LDL-C without...
Primary infection with varicella-zoster virus (VZV) causes the characteristic syndrome of varicella, or chickenpox. Experiments in severe combined immunodeficiency mice human skin grafts (SCIDhu mice) indicate that VZV T cells can mediate transfer infectious to skin. VZV-infected reached epithelial sites replication within 24 h after entering circulation. Memory CD4+ were predominant population recovered from SCIDhu given uninfected infected mononuclear cells, suggesting immune surveillance...
To implement personalized medicine, we established a large-scale patient cohort, BioBank Japan, in 2003. Japan contains DNA, serum, and clinical information derived from approximately 200,000 patients with 47 diseases. Serum were collected annually until 2012.We analyzed of participants at enrollment, including age, sex, body mass index, hypertension, smoking drinking status, across diseases, compared the results Japanese database on Patient Survey National Health Nutrition Survey. We...
The aim of the study was to clarify whether a therapeutic intervention focused on lifestyle modification affected incidence vascular complications in patients with established diabetes.A total 2,033 eligible Japanese men and women aged 40-70 years type 2 diabetes from 59 institutes were randomised conventional treatment group (CON), which continued receive usual care, (INT), received education regarding dietary habits, physical activities adherence by telephone counselling at each outpatient...
S-nitrosylation of the deacetylase SIRT1 functions as a proinflammatory switch in aging and inflammatory disorders.
OBJECTIVE To develop and validate a risk engine that calculates the risks of macro- microvascular complications in type 2 diabetes. RESEARCH DESIGN AND METHODS We analyzed pooled data from two clinical trials on 1,748 Japanese diabetic patients without diabetes other than mild retinopathy with median follow-up 7.2 years. End points were coronary heart disease (CHD), stroke, noncardiovascular mortality, overt nephropathy defined by persistent proteinuria, progression retinopathy. fit...
Although frailty and cognitive impairment are critical risk factors for disability mortality in the general population of older inhabitants, prevalence incidence these individuals treated specialty outpatient clinics unknown. We recently established a clinic comprehensive assessments conditions such as frailty, sarcopenia, cognition, planned 3-year prospective observational study to identify progression aging-related statuses. To date, we recruited 323 patients who revealed symptoms...
Preventing Chronic Disease (PCD) is a peer-reviewed electronic journal established by the National Center for Prevention and Health Promotion. PCD provides an open exchange of information knowledge among researchers, practitioners, policy makers, others who strive to improve health public through chronic disease prevention.
This paper described the Guideline for Diagnosis and Management of Hyperlipidemias Prevention Atherosclerosis proposed by The Japan Society (JAS) Investigating Committee (1, 995-2, 000) under auspices JAS Board Directors.1) guideline defines diagnostic criteria serum total cholesterol (Table 1), LDL-cholesterol triglycerides 4) HDL-cholesterol 7). It also indicates desirable range initiation levels management 2) target treatment LDL-cholesterol.2) Though both are shown as atherogenic...
BACKGROUND Interleukin (IL)-6 plays a central role as differentiation and growth factor of tumor cells. It may be hypothesized that increased serum IL-6 derives from the tissue, levels consequently reflect biologic characteristics tumor. The authors investigated association between in colorectal carcinoma patients well clinicopathologic status patients. METHODS Serum tissue 70 were determined using an immunoradiometric assay. Expression receptor evaluated immunohistochemically. proliferative...
OBJECTIVE—The metabolic syndrome (MetS) is believed to be associated with an increased risk of cardiovascular disease (CVD). Although its prevalence extremely high among diabetic patients, in those no history CVD has not been determined. Moreover, prospective studies published on the association between MetS and events populations have used only World Health Organization (WHO) definition included white European subjects. The aim this study was determine MetS, as defined by both WHO National...
Abstract Background Type 2 diabetes is associated with cognitive dysfunction and increases the risk of dementia in elderly. The aim this study was to explore, by means magnetic resonance (MR) imaging, possible relationships among clinical profiles diabetes, function, white matter hyperintensities (WMHs) subcortical brain atrophy. Methods Data were obtained from 95 nondemented type diabetic participants aged 65 years or over, enrolled an intervention trial for Japanese elderly patients....
Immunohistochemical studies were performed using specific antibodies to epidermal growth factor (EGF) and EGF receptor determine their presence cellular localization in the human ovary during follicular regression. There was no immunostaining for or primordial follicles. In preantral follicle stage, observed only oocyte. The staining intensity of oocyte increased as reached preovulatory stage. antral became apparent granulosa theca interna cell layers, without appreciable surrounding stromal...
The possible role of cyclic AMP-mediated phosphorylation events in the regulation exocrine secretion after p-adrenergic stimulation was examined vitro dispersed acinar cell aggregates from rat parotid gland.&Isoproterenol, a P-adrenergic agonist, stimulated endogenous activity AMP-dependent protein kinase, alterations 32P content 3 phosphoproteins (increased 2, M, = 27,000 and 14,000; decreased remaining, 13,600), amylase dose-dependent manner.All responses were half-maximal within range...
Abstract Merkel cell carcinoma is a rare malignancy that sometimes occurs in the skin of elderly people. Recently, new human polyomavirus, polyomavirus (MCPyV) was identified carcinoma. In present study, MCPyV‐DNA detected 6 11 (55%) cases by nested PCR and real‐time PCR. Histologically, MCPyV‐positive showed round vesicular nuclei with fine granular chromatin small nucleoli, whereas MCPyV‐negative polygonal diffusely distributed chromatin. Real‐time analysis to detect MCPyV gene revealed...