A5064451543- Salivary Gland Disorders and Functions
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Biochemical Analysis and Sensing Techniques
- Effects of Radiation Exposure
- Ion channel regulation and function
- Glycosylation and Glycoproteins Research
- Viral Infectious Diseases and Gene Expression in Insects
- Head and Neck Cancer Studies
- Herpesvirus Infections and Treatments
- Ion Transport and Channel Regulation
- Oral health in cancer treatment
- Viral gastroenteritis research and epidemiology
- Cancer Research and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Dental Health and Care Utilization
- Peptidase Inhibition and Analysis
- Neonatal Respiratory Health Research
- Oral microbiology and periodontitis research
- Pancreatic function and diabetes
- Olfactory and Sensory Function Studies
- Race, History, and American Society
- Cellular transport and secretion
Sanofi (France)
2025
Sanofi (United States)
2024
National Institute of Dental and Craniofacial Research
2012-2022
University of British Columbia
2009-2021
National Institutes of Health
2009-2019
Ford Foundation
2019
Institute of International Education
2019
Carnegie Corporation of New York
2019
Adler
2017
State Street (United States)
2014
Abstract Objective To assess the safety and potential efficacy of etanercept in treatment Sjögren's syndrome (SS). Methods This pilot study was a 12‐week randomized, double‐blind, placebo‐controlled trial etanercept, with 14 subjects each group. Patients received 25 mg or placebo (vehicle) by twice‐weekly subcutaneous injection. met American‐European Consensus Group criteria for SS. The primary outcome required at least 20% improvement from baseline values 2 following 3 domains: subjective...
A replication-deficient, recombinant adenovirus encoding human aquaporin-1 (hAQP1), the archetypal water channel, was constructed. This virus, AdhAQP1, directed hAQP1 expression in several epithelial cell lines vitro . In polarized MDCK monolayers, localized apical and basolateral plasma membranes. Fluid movement across monolayers infected by AdhAQP1 response to an osmotic gradient ≈4-fold that seen with uninfected or a control virus. When administered rat submandibular glands retrograde...
The production of stimulated parotid saliva was examined in 208 adults, aged 23-88 yr. Among men and women, taking no prescription medication, there diminution fluid output with increased age. Of subjects post-menopausal women (but not older men) produced at rates significantly lower than their non-medicated counterparts.
Both unstimulated and stimulated parotid saliva samples were collected from 85 healthy, unmedicated individuals between the ages of 23 81 years. There no significant differences in flow rate related to age with either or secretion.
Detection thresholds for each of the four basic taste qualities were obtained from 81 adults between 23 and 88 years age. Sodium chloride show a small but significant increase with age, confirming only previous observations derived procedures that control age-related changes in response criterion salivary sodium. Quinine sulfate display similar weaker relation to Sucrose citric acid are not significantly related Citric alone shows sex effect. undergo different
It is very well established that the principal control of salivary secretion derived from autonomic innervation. Transmission a neural signal to gland acinar cell occurs chemically via neurotransmitters, first messengers secretory response. Neurotransmitters bind specific surface receptor proteins, an event which activates precise transduction mechanisms then transfer inside cell. There are two major operative in cells. One involves generation cAMP, other breakdown plasma membrane...
Female nonobese diabetic (NOD) mice develop spontaneous autoimmune sialadenitis and loss of salivary flow, are a widely used model Sjögren's syndrome. We examined the feasibility local gland immunomodulatory gene delivery to alter these sequelae in NOD mice. constructed recombinant adeno-associated virus (rAAV) vectors encoding either human interleukin 10 (rAAVhIL-10) or beta-galactosidase (rAAVLacZ, control vector). Mice received rAAVhIL-10 rAAVLacZ by retrograde submandibular ductal...
Prostaglandin E1 and cholera toxin increased the intracellular levels of cyclic AMP human lung fibroblasts. With prostaglandin E1, increase in occurred within 10 min followed by a decline to less than one-half peak values 6 h. toxin, 60 but level remained for Both agents caused decrease collagen production as expressed proportion newly synthesized protein represented collagen. The was accompanied marked which degraded intracellularly prior secretion. Analysis showed it be predominantly 1000...
No conventional therapy exists for salivary hypofunction in surviving head and neck cancer patients with Radiation Therapy Oncology Group late grade 2-3 toxicity. We conducted a phase I clinical trial to test the safety biologic efficacy of serotype 5, adenoviral-mediated aquaporin-1 cDNA transfer single previously irradiated parotid gland 11 subjects using an open label, single-dose, dose-escalation design (AdhAQP1 vector; four dose tiers from 4.8 × 10(7) 5.8 10(9) vector particles per...
The production of unstimulated and citrate-stimulated submandibular saliva was examined in 90 male female adults, aged 26-93 years. None taking prescription medications for treatment systemic disease. There no diminution gland fluid output, at rest or during stimulation, with increasing age. Similar findings, previously reported the parotid glands, were also confirmed. These results demonstrate that major secretion capacity is maintained healthy older individuals.
A physical examination procedure was used to evaluate oral motor functions in a population of 257 community-dwelling males and females ranging age from 23-88 yr. An increased prevalence altered performance with found for parameters measuring lip posture masticatory muscle function. Also, males, but not females, showed higher alterations tongue function swallowing.
Using noninvasive real-time ultrasound, tongue movement was visualized during single swallowing in eight normal subjects and one neurologically impaired patient with dysphagia chronic aspiration. In normals, a clearly defined muscular wave of the tongue, traveling at approximately 15 cm/sec, carried 5-cc test water bolus posteriorly. who had 12th cranial nerve weakness, there complete absence activity no midtongue formation or transmission.
Abstract Head and neck cancer patients treated by radiation commonly suffer from a devastating side effect known as dry-mouth syndrome, which results the irreversible loss of salivary gland function via mechanisms that are not completely understood. In this study, we used mouse model radiation-induced hypofunction to investigate outcomes DNA damage in head region. We demonstrate was closely accompanied cellular senescence, evidenced persistent response (γH2AX 53BP1) expression...