A5074925904- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Nutrition and Health in Aging
- Cardiovascular Health and Disease Prevention
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Nutritional Studies and Diet
- Renal and Vascular Pathologies
- Renin-Angiotensin System Studies
- Frailty in Older Adults
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Dental Health and Care Utilization
- Adipokines, Inflammation, and Metabolic Diseases
- Dialysis and Renal Disease Management
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Aging and Gerontology Research
- Genetic Associations and Epidemiology
- Receptor Mechanisms and Signaling
- Ion Transport and Channel Regulation
- Temporomandibular Joint Disorders
- Sodium Intake and Health
- Dysphagia Assessment and Management
- Chronic Kidney Disease and Diabetes
Osaka University
2016-2025
Osaka Health Science University
2016-2025
Futaba (Japan)
2024
GTx (United States)
2003-2023
Keio University
2013-2023
Tokyo Metropolitan Institute of Gerontology
2015-2023
Department of Medical Sciences
2023
Osaka University of Human Sciences
2013-2023
Berkeley Public Health Division
2023
University of California, Berkeley
2023
von Willebrand factor (VWF) is synthesized primarily in vascular endothelial cells and secreted into the plasma as unusually large VWF multimers. Normally, these multimers are quickly degraded smaller forms by a metalloproteinase, VWF-cleaving protease (VWF-CP). Decreases activity of this enzyme result congenital acquired thrombotic thrombocytopenic purpura (TTP). The human VWF-CP has recently been purified. Cloning corresponding cDNA revealed that 1,427-aa polypeptide member ADAMTS gene...
Few prospective studies have examined the association between high-normal blood pressure and cardiovascular disease (CVD) in Asia. We impact of on incidence CVD a general urban population cohort Japan. studied 5494 Japanese individuals (ages 30 to 79 years without at baseline) after completing baseline survey who received follow-up through December 2005. Blood categories were defined basis ESH-ESC 2007 criteria. In 64 391 person-years follow-up, we documented 346 events. The frequencies...
Engagement in leisure activities has been claimed to be highly beneficial the elderly. Practicing such is supposed help older adults preserve cognitive function, physical and mental health, thus contribute successful aging. We used structural equation modeling (SEM) analyze impact of on these constructs a large sample Japanese (N = 809; age range 72–74). The model exhibited an excellent fit (CFI 1); engaging was positively associated with all three aging indicators. These findings...
Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients diabetes relatively higher glycemic levels. Here, we aimed clarify control was associated in type 2 diabetes.Study participants consisted of (n = 746, average age 69.9 years) an older general population 2,067, 68.2 years). Sarcopenia defined as weak grip strength or slow usual gait speed low skeletal...
Increased renal restive index (RI) measured using Doppler ultrasonography has been shown to correlate with the degree of impairment in hypertensive patients. We investigated prognostic role RI cardiovascular and outcomes. A total 426 essential subjects (mean age, 63 years; 50% female) no previous disease were included this study. Renal segmental arterial was by duplex ultrasonography. During follow-up (mean, 3.1 years), 57 participants developed primary composite end points including In...
The present study examined sex and age differences in taste sensitivity among young adult, young-old old-old Japanese.Participants were divided into three groups comprising 477 men 519 women the group (aged 69-71 years), 449 500 79-81 35 adult 24-32 years). Recognition thresholds for four basic tastes measured using 1-mL whole mouth gustatory test, which solutions of tested five concentrations.Young adults showed significantly lower recognition than group, group. Among groups, males sour,...
Elevated serum uric acid (UA) is frequently encountered in individuals with hypertension, but whether the relationship between UA and cardiovascular events circumstantial or causal remains to be answered. We examined association left ventricular mass index (LVMI) investigated prospectively combination of LVMI can predict incidence disease (CVD) asymptomatic subjects essential hypertension. A total 619 (mean age, 61 years; 52% female) free prior CVD were included this study. significant was...
Chronic kidney disease (CKD) has recently been recognized to be a powerful predictor of cardiovascular morbidity and mortality. Atrial fibrillation (AF), which is common arrhythmia in hypertensives, associated with increased risks events death. However, the association between CKD onset AF not fully elucidated. The present study assessed hypothesis that may influence hypertensives.A total 1118 hypertensive patients (mean age, 63 years) without previous paroxysmal AF, heart failure,...
Chronic kidney disease (CKD) is increasingly recognized as an independent risk factor for stroke and myocardial infarction (MI). Few studies, however, have examined the relationship between blood pressure (BP) category these diseases in subjects with without CKD.We studied 5494 Japanese individuals (ages 30 to 79, or MI at baseline) who completed a baseline survey received follow-up through December 2005. The glomerular filtration rate (GFR) was estimated using Modification of Diet Renal...
ACE type 2 (ACE2) functions as a negative regulator of the renin-angiotensin system by cleaving angiotensin II (AII) into 1-7 (A1-7). This study assessed role endogenous ACE2 in maintaining insulin sensitivity. Twelve-week-old male knockout (ACE2KO) mice had normal sensitivities when fed standard diet. AII infusion or high-fat, high-sucrose (HFHS) diet impaired glucose tolerance and sensitivity more severely ACE2KO than their wild-type (WT) littermates. The strain difference was not...
An increasing number of studies in Western countries have shown that healthy dietary patterns may a protective effect against cognitive decline and dementia. However, information on this relationship among non-Western populations with different cultural settings is extremely limited. We aim to examine the between function older Japanese people.This cross-sectional study included 635 community-dwelling people aged 69-71 years who participated prospective cohort titled Septuagenarians,...
The increasing number of patients undergoing dialysis due to diabetes mellitus (DM) is causing serious economic problems, and its reduction an urgent policy issue in developed countries, including Japan. We aimed assess the association between annual rapid decline renal function health checkup measures, blood pressure, identify guidance targets for preventing diabetic nephropathy (DN) kidney disease (DKD) among individuals a medical system ("Tokuteikenshin" program) 2018. This longitudinal...
Aim This study examined the association between number of prescribed medications and falls among community‐dwelling older adults. Methods We conducted a geriatric comprehensive health‐checkup on adults aged 69–91 years who participated in Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. The final analysis this included 1,076 participants complete data. were divided into four groups based at baseline: 0, 1, 2–4, ≥5. At 3‐year follow‐up, asked whether they...
Objectives Mice deficient in the regulator of G-protein signaling 2 (RGS2) exhibit a strong hypertensive phenotype. We studied whether genetic variations RGS2 are implicated hypertension or other phenotypes Japanese individuals and general population. Methods sequenced all exons promoter region 953 48 individuals, respectively. Genotyping by TaqMan polymerase chain reaction method was performed for six missense frameshift mutations common single nucleotide polymorphisms population, with...
Recent studies have shown that an elevated ambulatory or home blood pressure (BP) in the absence of office BP-a phenomenon called masked hypertension-is associated with poor cardiovascular prognosis. However, it remains to be elucidated how hypertension modifies target organ damage treated hypertensive patients.A total 332 outpatients chronically essential were enrolled present study. Patients classified into four groups according (<140/90 >or=140/90 mm Hg) and daytime (<135/85 >or=135/85 BP...