A5025621056- Marine and fisheries research
- Marine Bivalve and Aquaculture Studies
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Fish Ecology and Management Studies
- Williams Syndrome Research
- Hydrology and Watershed Management Studies
- Autism Spectrum Disorder Research
- Hydrology and Sediment Transport Processes
- Aquaculture Nutrition and Growth
- Lung Cancer Treatments and Mutations
- Soil erosion and sediment transport
- Fish Biology and Ecology Studies
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Isotope Analysis in Ecology
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Ocean Acidification Effects and Responses
- Epigenetics and DNA Methylation
- Food Industry and Aquatic Biology
- earthquake and tectonic studies
- Marine and coastal plant biology
- Hippo pathway signaling and YAP/TAZ
- Geological and Geochemical Analysis
Kyoto University
2013-2024
Aichi Cancer Center
2020-2024
Nagoya University
2024
Tokyo University of Science
2024
Fukuoka University
2024
Mitsubishi Electric (Netherlands)
2023
Mitsubishi Electric (Japan)
2022
Tohoku Medical and Pharmaceutical University
2022
Japan Community Healthcare Organization
2020
Chukyo Hospital
2020
Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs) autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 ASD cases, 2,458 SCZ 2,095 controls Japanese population confirmed an increased burden of rare exonic CNVs both disorders. Clinically significant (or pathogenic) CNVs, including those at 29 loci common to disorders, were found about 8% which was significantly higher than controls. Phenotypic analysis revealed association...
Abstract Purpose: KRAS is among the most commonly mutated oncogene in cancer including non–small cell lung (NSCLC). In early clinical trials, inhibitors targeting G12C-mutant have achieved responses some patients with NSCLC. Possible intrinsic and acquired resistance mechanisms to G12C are not fully elucidated will likely become important identify. Experimental Design: To identify potential mechanisms, we defined sensitivity of a panel G12C–mutant lines inhibitor, AMG510. Gene set enrichment...
We scanned throughout chromosome 21 to assess genetic associations with late-onset Alzheimer disease (AD) using 374 Japanese patients and 375 population-based controls, because trisomy is known be associated early deposition of beta-amyloid (Abeta) in the brain. Among 417 markers spanning 33 Mb, 22 showed either allele or genotype frequency (P < 0.05). Logistic regression analysis age, sex apolipoprotein E (APOE)-epsilon4 dose supported risk 17 markers, which eight were linked SAMSN1, PRSS7,...
The Japanese sardine Sardinops melanostictus started to decline after 1989. Recruitment age 1 population was small in four year-classes from 1988 1991. 1989 resulted recruitment failures 4 consecutive years. Egg production high the years of poor recruitment. were caused not by a reduction reproductive output but low survival between egg stage and Abundance post first-feeding larvae positively correlated with yolksac larval abundance. Mortality at so variable as destroy correlations abundance...
Abstract Brassica self-incompatibility (SI) is controlled by SLG and SRK expressed in the stigma SP11/SCR anther. We determined sequences of S domains 36 alleles, 13 14 SP11 alleles from oleracea B. rapa. found three haplotypes lacking genes rapa, confirming that not essential for SI recognition system. Together with reported sequences, nucleotide diversities per synonymous nonsynonymous site (πS πN) at SRK, SLG, loci within were computed. The ratios πN:πS hypervariable region significantly...
BackgroundWe aimed to determine the similarities and differences in roles of genic regulatory copy number variations (CNVs) bipolar disorder (BD), schizophrenia (SCZ), autism spectrum (ASD).MethodsBased on high-resolution CNV data from 8708 Japanese samples, we performed our knowledge largest cross-disorder analysis CNVs BD, SCZ, ASD.ResultsIn CNVs, found an increased burden smaller (<100 kb) exonic deletions which contrasted with highest larger (>500 SCZ/ASD. Pathogenic linked...
The canonical pathway of Notch signaling is mediated by regulated intramembrane proteolysis (RIP). In the pathway, ligand binding results in sequential receptor, and presenilin (PS)-dependent at interface between membrane cytosol liberates Notch-1 intracellular domain (NICD), a transcription modifier. Because degradation transmembrane thought to require an additional cleavage near middle domain, extracellular small peptides (Notch-1 Abeta-like peptide (Nbeta)) should be produced. Here we...
Polymyositis and dermatomyositis are inflammatory muscular diseases of unknown etiology which have interstitial pneumonitis as a serious complication. From 1987 to 1994, we used cyclosporine treat 14 polymyositis/dermatomyositis patients (8 with 6 without pneumonitis). In combination prednisolone, was either added or substituted for conventional cytotoxic drugs (azathioprine, cyclophosphamide methotrexate). Cyclosporine effective against both myositis when early in the course disease.
Les aires de ponte du pilchard Japon (Sardinops melanostictus) se sont etendues, pendant une periode d'accroissement la population survenue dans premiere moitie des annees 1980, eaux plateau continental le long cote pacifique jusqu'aux oceaniques situees aux alentours courant Kuroshio. La superficie frayeres est passee 150 000 km 2 en 1978 a 290 1990. densite annuelle moyenne distribution oeufs sur l'ensemble 1500.m -2 19 400.m 1986. Le pourcentage survie les 10 premiers jours vie environ...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 278:297-302 (2004) - doi:10.3354/meps278297 Growth-selective predation hypothesis revisited for larval anchovy in offshore waters: cannibalism by juveniles versus skipjack tunas Akinori Takasuka1,*, Yoshioki Oozeki1, Ryo Kimura2, Hiroshi Kubota1, Ichiro Aoki3 1National Research Institute of Fisheries Science,...
We used an up-to-date, a high accuracy CO2 manipulation system to investigate the sensitivity of organisms acidification, rearing marine calcifiers under elevated in running water. evaluated effects partial pressures carbon dioxide (pCO2) seawater on larvae commercially important gastropod Ezo abalone Haliotis discus hannai. In larval abalone, no effect exposure <1100 μatm pCO2 was observed fertilization, malformation, or mortality rates until 15 h after fertilization. However, compared...
Pompe disease is caused by an inborn defect of lysosomal acid α-glucosidase (GAA) and characterized glycogen accumulation primarily in the skeletal muscle heart. Patients with severe type disease, infantile-onset (IOPD), show generalized weakness heart failure early infancy. They cannot survive over two years. Enzyme replacement therapy recombinant human GAA (rhGAA) improves survival rate, but its effect on insufficient compared to other organs. Moreover, patho-mechanism damage IOPD still...
Significance Genetic studies of common complex human diseases, including Alzheimer's disease (AD), are extremely resource-intensive and have struggled to identify genes that causal in disease. Combined with the costs inability missing heritability, particularly AD, alternate strategies warrant consideration. We devised a unique strategy combines distinct mouse strains vary naturally amyloid-β production transcriptomics kinesin light chain-1 (Klc1 ) splice variant E as modifier accumulation,...
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental characterized by social communication deficits and repetitive behaviors. Owing to the difficulty of clinical diagnosis, ASD without intellectual disability (i.e., high-functioning ASD) often overlooked. MicroRNAs (miRNAs) have been recently recognized as potential biomarkers they are dysregulated in various tissues individuals with ASD. However, it remains unclear whether miRNA expression altered Here, we investigated profile...
Williams syndrome (WS) is caused by a microdeletion of chromosome 7q11.23, and characterized various physical cognitive symptoms. In particular, WS hypersocial (overfriendly) behavior; has gained attention as aspects the phenotype contrast with those autism spectrum disorder (ASD). The oxytocin receptor gene (OXTR) contributes to social phenotypes in relation regulation (OXT) secretion. Additionally, mounting evidence recently shown that DNA methylation OXTR associated human behavior....
Increasing evidence suggests that epigenetic mechanisms play a role in the etiology of autism spectrum disorder (ASD). To date, several studies have attempted to identify biomarkers for ASD. However, reliable markers remain be established and most these focused on pediatric patients with In this study, we sought find an DNA methylation biomarker from peripheral blood adult high-functioning profiles were analyzed using Illumina 450 K array. robust candidate markers, employed two types...
Abstract Williams syndrome (WS) is a rare genetic disorder, caused by microdeletion at the 7q11.23 region. WS exhibits wide spectrum of features including hypersociability, which contrasts with social deficits typically associated autism disorders. The phenotypic variability in likely involves epigenetic modifications; however, nature these events remains unclear. To better understand role epigenetics phenotypes, we integrated DNA methylation and gene expression profiles blood from patients...
Background Autism spectrum disorder (ASD) is characterized by impaired social communication and behavioral problems. An increased risk of premature mortality has been observed in individuals with ASD. Therefore, we hypothesized that biological aging accelerated Recently, several studies have established genome-wide DNA methylation (DNAm) profiles as ‘epigenetic clocks’ can estimate aging. In addition, ASD associated differential DNAm patterns. Methods We used two independent datasets from...