A5042335595- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Fermentation and Sensory Analysis
- GaN-based semiconductor devices and materials
- Functional Brain Connectivity Studies
- Pancreatic and Hepatic Oncology Research
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Treatment of Major Depression
- Esophageal and GI Pathology
- Advanced Radiotherapy Techniques
- Liver Disease and Transplantation
- Semiconductor Quantum Structures and Devices
- Liver Disease Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Ga2O3 and related materials
- Tryptophan and brain disorders
- Gastroesophageal reflux and treatments
- Suicide and Self-Harm Studies
- Lung Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microbial Metabolic Engineering and Bioproduction
Hokkaido University
2016-2025
Aomori Prefectural Central Hospital
2013-2025
National Center of Neurology and Psychiatry
2022-2025
Waseda University
2025
Sanden (Japan)
2019-2024
Hokkaido University Hospital
2020-2024
Kyoto University
2017-2024
Tottori University
2024
Tokyo Metropolitan University
2024
Osaka Metropolitan University
2024
Subcortical structures, which include the basal ganglia and parts of limbic system, have key roles in learning, motor control emotion, but also contribute to higher-order executive functions. Prior studies reported volumetric alterations subcortical regions schizophrenia. Reported results sometimes been heterogeneous, few large-scale investigations conducted. Moreover, assessed asymmetries volumes Here, as a work completely independent study performed by ENIGMA consortium, we conducted...
Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs) autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 ASD cases, 2,458 SCZ 2,095 controls Japanese population confirmed an increased burden of rare exonic CNVs both disorders. Clinically significant (or pathogenic) CNVs, including those at 29 loci common to disorders, were found about 8% which was significantly higher than controls. Phenotypic analysis revealed association...
Alcohol acetyltransferase responsible for the formation of acetate esters during beer fermentation was found to be localized at cell membrane brewers' yeast. This membrane-bound enzyme purified 120-fold by solubilization with Triton X-100, gel filtration on a Sepharose 6B column and chromatography DEAE-Sephadex A-50 column. The most active 30°C pH 7 ˜ 8. It least against C3 alcohol among C1 C6 alcohols, slightly more straight-chain alcohols than branched-chain same carbon number. strongly...
Alcohol acetyltransferase responsible for the formation of acetate esters during beer fermentation was found to be localized at cell membrane brewers' yeast. This membrane-bound enzyme purified 120-fold by solubilization with Triton X-100, gel filtration on a Sepharose 6B column and chromatography DEAE-Sephadex A-50 column. The most active 30°C pH 78. It least against C3 alcohol among C1C6 alcohols, slightly more straight-chain alcohols than branched-chain same carbon number. strongly...
Aim Studies have reported that cognitive decline occurs after the onset of schizophrenia despite heterogeneity in function among patients. The aim this study was to investigate degree estimated patients with by comparing premorbid intellectual functioning and current functioning. Methods A total 446 (228 male, 218 female), consisting three sample sets obtained from 11 psychiatric facilities, 686 healthy controls participated study. Wechsler Adult Intelligence Scale‐ III ( WAIS‐III ) used...
BackgroundWe aimed to determine the similarities and differences in roles of genic regulatory copy number variations (CNVs) bipolar disorder (BD), schizophrenia (SCZ), autism spectrum (ASD).MethodsBased on high-resolution CNV data from 8708 Japanese samples, we performed our knowledge largest cross-disorder analysis CNVs BD, SCZ, ASD.ResultsIn CNVs, found an increased burden smaller (<100 kb) exonic deletions which contrasted with highest larger (>500 SCZ/ASD. Pathogenic linked...
Abstract Differential diagnosis is sometimes difficult in practical psychiatric settings, terms of using the current diagnostic system based on presenting symptoms and signs. The creation a novel objective biomarkers expected to take place. Neuroimaging studies others reported that subcortical brain structures are hubs for various psycho-behavioral functions, while there so far no neuroimaging data-driven clinical criteria overcoming limitations system, which would reflect cognitive/social...
Abstract According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive (MDD), and autism spectrum (ASD) are classified based on symptoms. While its cluster of symptoms defines each these disorders, there is also an overlap in between disorders. We hypothesized that similarities differences cortical structural neuroimaging features among T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects...
This study retrospectively evaluated the efficacy and toxicity of particle therapy using carbon ions or protons for primary sacral chordomas.We 23 patients with chordoma treated ion (CIT) proton (PT) between July 2005 June 2011 at Hyogo Ion Beam Medical Center, Hyogo, Japan. The median patient age was 72 years. 14 were 70.4 Gy equivalents (GyE) in 16 fractions 9 GyE 32 fractions. CIT used patients, PT 7 patients.The follow-up period 38 months. At 3 years, local control (LC), overall survival...
Volatile aldehydes are formed during storage of bottled beer on the shelf and give an off-flavour. Results showed that these by oxidation higher alcohols in with melanoidins. On alcohols, hydrogen or electron is probably transferred from to reactive carbonyl groups melanoidins lower molecular weights. The amino-carbonyl reaction boiling wort. Molecular oxygen does not oxidize absence melanoidins, but accelerates their proceeds more rapidly at high temperature low pH value.
To study the oncological outcome of patients with unresectable locally advanced primary head and neck cancers invading skull base, treated particle radiotherapy.Fifty-seven base received proton or carbon ion radiotherapy as definitive treatment at Hyogo Ion Beam Medical Center between 2003 2009. Forty-seven were 10 radiotherapy. A retrospective review was performed clinical charts recorded imagings.With a median follow-up 32 months, 3-year actual survival local progression-free rates all 61...
A practical synthesis of a variety λ5-phosphinines, which show distinct fluorescence both in solution and solid state, is described. Both C4-selective electrophilic substitutions the following conversions realized an easy preparation wide range derivatives having several substituents for electronic modification, provides potential fine-tuning photophysical properties.
Monopharmacy with antipsychotics and antidepressants is the first-line treatment for schizophrenia major depressive disorder (MDD) in most clinical guidelines, while polypharmacy psychotropic agents of common practice. There are no detailed data on prescription patterns inpatients mental illness reliable diagnoses made by treating psychiatrists. We gathered at discharge from 2177 patients 1238 MDD October 2016 to March 2018. The aged between 60 79 were prescribed lower doses...
"Foaming proteins" that retained the full foaming capacity of original beer were isolated by ultrafiltration followed ammonium sulfate precipitation and ion-exchange chromatography on diethylaminoethylcellulose. Because content proteins correlated well with head formation many samples beer, these seem to be responsible for foaming. Foaming consisted three fractions molecular weights 90,000–1,000,000, 40,000, 15,000. These all surface-active but differed in mechanism their contribution The...
Aim: Suicide is associated not only with primary psychiatric disorders but also physical disorders. Physicians' education on suicide prevention contributes to reducing suicide. Therefore, medical residents, who contact patients daily and eventually become physicians in each specialty, might be the most appropriate candidates for intervention. In this article, we introduce our newly developed intervention program among residents. Methods: We a 2‐hour based Mental Health First Aid (MHFA),...