A5001646293- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Advanced MRI Techniques and Applications
- Genomic variations and chromosomal abnormalities
- Neuroscience and Music Perception
- Genomics and Rare Diseases
- Neural dynamics and brain function
- Advanced Glycation End Products research
- Autism Spectrum Disorder Research
- Alzheimer's disease research and treatments
- RNA and protein synthesis mechanisms
- Morphological variations and asymmetry
- Mental Health Research Topics
- Monoclonal and Polyclonal Antibodies Research
- Diet and metabolism studies
- Hemispheric Asymmetry in Neuroscience
- Phytoestrogen effects and research
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Biochemical effects in animals
- Neural and Behavioral Psychology Studies
- Chromosomal and Genetic Variations
Kyoto University
2014-2024
Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs) autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 ASD cases, 2,458 SCZ 2,095 controls Japanese population confirmed an increased burden of rare exonic CNVs both disorders. Clinically significant (or pathogenic) CNVs, including those at 29 loci common to disorders, were found about 8% which was significantly higher than controls. Phenotypic analysis revealed association...
BackgroundWe aimed to determine the similarities and differences in roles of genic regulatory copy number variations (CNVs) bipolar disorder (BD), schizophrenia (SCZ), autism spectrum (ASD).MethodsBased on high-resolution CNV data from 8708 Japanese samples, we performed our knowledge largest cross-disorder analysis CNVs BD, SCZ, ASD.ResultsIn CNVs, found an increased burden smaller (<100 kb) exonic deletions which contrasted with highest larger (>500 SCZ/ASD. Pathogenic linked...
Human cortical gray matter (GM) is structurally asymmetrical and this asymmetry has been discussed to be partly responsible for functional lateralization of human cognition behavior.Past studies on brain have shown mixed results so far, with some focusing the global shapes brain's surface, such as gyrification patterns, while others focused regional volumes.In study, we investigated GM asymmetries in a large sample right-handed healthy volunteers (n 5 101), using surface-based method which...
The effect of duration illness and antipsychotic medication on the volumes subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions meta-analysis. Imaging 778 subjects were taken prospective meta-analysis conducted by COCORO consortium Japan. daily dose type antipsychotics assessed using linear mixed model where computed FreeSurfer used as dependent variable age, sex, illness,...
Schizophrenia is an etiologically and clinically heterogeneous disorder. Although neuroimaging studies have revealed brain alterations in schizophrenia, most assumed that the disorder a single entity, neglecting diversity of observed The current study sought to explore distinct patterns altered cortical thickness patients with schizophrenia healthy individuals using data-driven approach. Unsupervised clustering self-organizing maps followed by K-means algorithm was applied regional data 108...
Autism spectrum disorder (ASD) is caused by combined genetic and environmental factors. Genetic heritability in ASD estimated as 60–90%, investigations have revealed many monogenic We analyzed 405 patients with using family-based exome sequencing to detect disease-causing single-nucleotide variants (SNVs), small insertions deletions (indels), copy number variations (CNVs) for molecular diagnoses. All candidate were validated Sanger or quantitative polymerase chain reaction evaluated the...
Abstract Objectives Schizophrenia is a mental illness that presents with thought disorders including delusions and disorganized speech. Thought have been regarded as consequence of the loosening associations between semantic concepts since term “schizophrenia” was first coined by Bleuler. However, mechanistic account this cardinal disturbance in terms functional dysconnection has lacking. To evaluate how aberrant connections are expressed through brain activity, we characterized large-scale...
Echo-planar imaging is a common technique used in functional magnetic resonance (fMRI); however, it suffers from image distortion and signal loss because of large susceptibility effects that are related to the phase-encoding direction scan. Despite this relation, majority neuroimaging studies has not considered influence direction. Here, we aimed clarify how can affect outcome an fMRI connectivity study schizophrenia (SCZ).Resting-state using anterior posterior (A-P) (P-A) directions was...
Abstract Several studies have shown white matter (WM) dysconnectivity in people with schizophrenia (SZ). However, the underlying mechanism remains unclear. We investigated relationship between plasma homocysteine (Hcy) levels and WM microstructure SZ using diffusion tensor imaging (DTI). Fifty-three 83 healthy controls (HC) were included this retrospective observational study. Tract-Based Spatial Statistics (TBSS) used to evaluate group differences microstructure. A significant negative...
Abstract Schizophrenia patients often manifest semantic processing deficits. It has been proposed that these deficits stem from disorganized representations in the brain. However, no study yet examined neural correlates of disorganization by directly evaluating We used voxelwise modeling on functional magnetic resonance imaging signals to evaluate associated with several thousand words individual patient brains. then compared structural properties those healthy controls. The variability was...
Abstract While it is known that cultural background influences the healthy brain, less about how affects cortical changes in schizophrenia. Here, we tested whether schizophrenia differentially affected brain Japanese and German patients. In a sample of 155 patients with diagnosis 191 controls from Japan Germany, acquired 3 T-MRI brain. We subsequently compared thickness surface area to identify differences between might be influenced by ethnicity. Additional analyses were performed account...
Abstract Autoantibodies have been implicated in schizophrenia aetiology. Here, novel autoantibodies were isolated from patients with schizophrenia. Autoantibody candidates searched using two-dimensional gel electrophoresis and western blotting rat brain proteins as antigens two sera pools (25 versus 25 controls) antibodies. Immunoreactive identified by mass spectrometry. Antibody prevalence evaluated human recombinant proteins. Furthermore, magnetic resonance imaging data (regional volumes...
Abstract Carbonyl stress is a condition featuring increased rich reactive carbonyl compounds, which facilitate the formation of advanced glycation end products including pentosidine. We previously reported relationship between enhanced and disrupted white matter integrity in schizophrenia, although microstructural component remained unclear. In this study, 32 patients with schizophrenia (SCZ) 45 age- gender-matched healthy volunteers (HC) were recruited. obtained blood samples for markers...
Abstract Carbonyl stress is a condition featuring increased rich reactive carbonyl compounds, which facilitate the formation of advanced glycation end products including pentosidine. We previously reported relationship between enhanced and disrupted white matter integrity in schizophrenia, although microstructural component remained unclear. In this study, 32 patients with schizophrenia (SCZ) 45 age-and gender-matched healthy volunteers (HC) were recruited. obtained blood samples for markers...