A5065111183- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Microstructure and Mechanical Properties of Steels
- Schizophrenia research and treatment
- Metal Alloys Wear and Properties
- Dementia and Cognitive Impairment Research
- Autism Spectrum Disorder Research
- Medical Imaging Techniques and Applications
- Metallurgy and Material Forming
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Fatigue and fracture mechanics
- Hydrogen embrittlement and corrosion behaviors in metals
- Treatment of Major Depression
- Attention Deficit Hyperactivity Disorder
- Behavioral and Psychological Studies
- Obsessive-Compulsive Spectrum Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Epilepsy research and treatment
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
National Institutes for Quantum Science and Technology
2016-2025
Kyoto University
2016-2025
Kubota (Japan)
2017-2025
Showa University
2017-2023
Nippon Steel (Japan)
2011-2020
Showa University Karasuyama Hospital
2018-2020
Hokkaido Agricultural Research Center
2020
RELX Group (Netherlands)
2019
University Medical Center Utrecht
2015-2018
Utrecht University
2018
<h3>Importance</h3> Although schizophrenia is characterized by impairments in intelligence and the loss of brain volume, relationship between changes IQ measures not clear. <h3>Objective</h3> To investigate association patients with across time. <h3>Design, Setting, Participants</h3> Case-control longitudinal study at Department Psychiatry University Medical Center Utrecht, Netherlands, comparing healthy control participants September 22, 2004, April 17, 2008. Magnetic resonance imaging...
Dysfunction of the thalamocortical pathway has been proposed as a putative underlying pathology schizophrenia. Although mechanisms involved remain unclear, postmortem studies suggest involvement altered neural projections from thalamus to layers within prefrontal cortex.To investigate connectivity in schizophrenia and examine its possible association with cortical thinning vivo.Case-control cross-sectional study.Department Psychiatry at Kyoto University Hospital, Japan.A total 37 patients 36...
Is tau load associated with long-term outcomes of TBI? By using PET to assess deposits in patients chronic TBI, Takahata et al. reveal elevated compared age-matched controls, and show that the abundance white matter is late-onset neuropsychiatric symptoms.
Human cortical gray matter (GM) is structurally asymmetrical and this asymmetry has been discussed to be partly responsible for functional lateralization of human cognition behavior.Past studies on brain have shown mixed results so far, with some focusing the global shapes brain's surface, such as gyrification patterns, while others focused regional volumes.In study, we investigated GM asymmetries in a large sample right-handed healthy volunteers (n 5 101), using surface-based method which...
Although the ability to make optimal decisions under uncertainty is an integral part of everyday life, individuals with autism spectrum disorder (ASD) frequently report that they experience difficulties this skill. In behavioral economics, researchers distinguish two types understand decision-making in setting: risk (known probabilities) and ambiguity (unknown probabilities). However, it remains unclear how ASD behave ambiguity, despite growing evidence their altered uncertainty. We...
Abstract Frontotemporal dementia refers to a group of neurodegenerative disorders with diverse clinical and neuropathological features. In vivo assessments frontotemporal at an individual level have hitherto not been successful. this study, we aim classify patients based on topologies tau protein aggregates captured by PET 18F-florzolotau (aka 18F-APN-1607 18F-PM-PBB3), which allows high-contrast imaging fibrils in Alzheimer’s disease as well non–Alzheimer’s tauopathies. Twenty-six dementia,...
Abstract A number of magnetic resonance imaging (MRI) studies have revealed morphological cortical asymmetry in the normal human brain, and reduction or inversion such hemispheric has been reported schizophrenia. On other hand, diffusion tensor (DTI) inconsistent findings concerning abnormal white matter integrity Our aim was to confirm whether there is reduced inverted whole brain For this study, 26 right‐handed schizophrenia patients, 32 matched healthy control subjects were investigated....
Schizophrenia is an etiologically and clinically heterogeneous disorder. Although neuroimaging studies have revealed brain alterations in schizophrenia, most assumed that the disorder a single entity, neglecting diversity of observed The current study sought to explore distinct patterns altered cortical thickness patients with schizophrenia healthy individuals using data-driven approach. Unsupervised clustering self-organizing maps followed by K-means algorithm was applied regional data 108...
The norepinephrine transporter in the brain has been targeted treatment of psychiatric disorders. Duloxetine is a serotonin and reuptake inhibitor that widely used for depression. However, relationship between dose plasma concentration duloxetine occupancy human not determined. In this study, we examined by different doses duloxetine.We calculated occupancies from 2 positron emission tomography scans using (S,S)-[18F]FMeNER-D2 before after single oral (20 mg, n = 3; 40 60 =2). Positron were...
Although the relationship between schizophrenia spectrum disorder (SSD) and autism (ASD) has long been debated, it not yet fully elucidated. The authors quantified visualized ASD SSD using dual classifiers that discriminate patients from healthy controls (HCs) based on resting-state functional connectivity magnetic resonance imaging. To develop a reliable classifier, sophisticated machine-learning algorithms automatically selected SSD-specific connections were applied to Japanese datasets...
Abstract Increased excitatory neuronal tones have been implicated in autism, but its mechanism remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic circuits, which can be affected by astrocyte activation and suppressive signaling of dopamine neurotransmission. We tested this hypothesis using magnetic resonance spectroscopy positron emission tomography scan with 11 C-SCH23390 for D1 receptors the anterior cingulate cortex (ACC). enrolled 18 male adults...
Previous neuroimaging studies have revealed that both gray matter (GM) and white (WM) are altered in several morphological aspects schizophrenia patients. Although reported associations between GM WM alterations restricted regions, the existence of a global association pathologies is unknown. Considering wide distribution changes profound genetic background abnormalities, it would be natural to postulate schizophrenia. In this investigation, we studied 35 patients healthy control subjects...
Objective Apathy is a common neuropsychological symptom in Alzheimer’s disease (AD), and previous studies demonstrated that neuronal loss network disruption some brain regions play pivotal roles the pathogenesis of apathy. However, contributions tau amyloid-β (Aβ) depositions, pathological hallmarks AD, to manifestation apathy remain elusive. Methods Seventeen patients with AD underwent positron emission tomography (PET) 11 C-pyridinyl-butadienyl-benzothiazole 3 ( C-PBB3) C-Pittsburgh...
Abstract Intergroup bias, which is the tendency to behave more positively toward an in‐group member than out‐group member, pervasive in real life. In particular, intergroup bias trust decisions substantially influences multiple areas of life and thus better understanding this can provide significant insights into human social behavior. Although previous functional magnetic resonance imaging studies showed involvement right temporoparietal junction (TPJ) a causal relationship between two has...
Although previous studies have suggested the involvement of dopamine (DA) and noradrenaline (NA) neurotransmissions in autism spectrum disorder (ASD) pathophysiology, few examined these individuals with ASD vivo. Here, we investigated DA D1 receptor (D1R) transporter (NAT) binding adults (n = 18) neurotypical controls 20) by utilizing two different PET radioligands, [11C]SCH23390 (S,S)-[18F]FMeNER-D2, respectively. We found no significant group differences D1R (striatum, anterior cingulate...