A5077112770- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Bipolar Disorder and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Epigenetics and DNA Methylation
- Treatment of Major Depression
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Autism Spectrum Disorder Research
- Electroconvulsive Therapy Studies
- Eating Disorders and Behaviors
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Folate and B Vitamins Research
- Mental Health Research Topics
- Mental Health and Psychiatry
- Phosphodiesterase function and regulation
- Heart Rate Variability and Autonomic Control
- Optical Imaging and Spectroscopy Techniques
Tokushima University
2015-2024
Osaka University
2018
Kanazawa University
2018
RIKEN Center for Brain Science
2018
Fujita Health University
2018
Kōchi University
2018
University of Tsukuba
2016
Institute of Biomedical Science
2016
Brain (Germany)
2013-2015
Institute for Medical Informatics and Biostatistics
2013-2015
Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs) autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 ASD cases, 2,458 SCZ 2,095 controls Japanese population confirmed an increased burden of rare exonic CNVs both disorders. Clinically significant (or pathogenic) CNVs, including those at 29 loci common to disorders, were found about 8% which was significantly higher than controls. Phenotypic analysis revealed association...
Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In present GWAS (Phase I/II), which included 2964 61 887 control subjects from Japanese population, we detected a novel locus at 11q12.2 (rs28456, P=6.4 × 10−9), region known contain regulatory genes plasma lipid levels (FADS1/2/3). A subsequent meta-analysis...
This preliminary study was performed to test the reliability and validity of Brief Assessment Cognition in Schizophrenia (BACS) as an assessment tool a Japanese-language version (BACS-J). The subjects for present were 30 outpatients with chronic schizophrenia. Each subject gave written informed consent participate research. Cronbach's alpha BACS-J 0.77. composite score significantly correlated all primary measures (verbal memory, working motor speed, verbal fluency, attention, executive...
Aberrant DNA methylation in the blood of patients with major depressive disorder (MDD) has been reported several previous studies. However, no comprehensive studies using medication-free subjects MDD have conducted. Furthermore, majority these limited to analysis CpG sites islands (CGIs) gene promoter regions. The main aim present study is identify markers that distinguish from non-psychiatric controls. Genome-wide profiling peripheral leukocytes was conducted two set samples, a discovery...
DNA methylation, which is most frequently the transference of a methyl group to 5-carbon position cytosine in CpG dinucleotide, plays an important role both normal development and diseases. To date, several genome-wide methylome studies have revealed sex-biased yet no investigated sex differences methylation by taking into account cellular heterogeneity. The aim present study was investigate on autosomes human blood adjusting for estimated proportions because cell-type may vary sex.We...
Abstract There is high mortality among patients with bipolar disorder (BD). Studies have reported accelerated biological aging in BD. Recently, Horvath and Hannum et al. independently developed DNA methylation (DNAm) profiles as “epigenetic clocks,” which are the most accurate age estimate. This led to development of two accomplished measures epigenetic acceleration (EAA) using blood samples, namely, intrinsic extrinsic EAA (IEAA EEAA, respectively). IEAA, based on Horvath’s clock,...
Abstract The Trail‐Making Test (TMT) is a neuropsychological test for evaluating executive function, and the TMT Part B reflects more complex cognitive processes including set shifting. prefrontal cortex (PFC) thought to be involved in these processes. purpose of present paper was investigate PFC activation during performance A using multichannel near‐infrared spectroscopy (NIRS). Subjects were 41 healthy right‐handed volunteers. hemodynamic changes measured on 22‐channel NIRS machine....
Aim: In recent years, greater attention has been given to quality of life (QOL) in schizophrenia and several studies reported that negative depressive symptoms cognitive dysfunction are related patient QOL. But because a variety QOL measures have used the previous studies, there seems be no unanimous predictors for subjective objective The purpose present study was elucidate relationship between clinical variables outpatients with schizophrenia, using disease‐specific measures. Particular...
Abstract Recent researches have suggested that brain‐derived neurotrophic factor (BDNF) may be implicated in the pathophysiology of mood disorder. This study examined association between BDNF Val66Met polymorphism and major depressive disorder (MDD) a Japanese population. We genotyped 154 patients age‐ sex‐matched control subjects. The genotypic distributions allele frequencies were similar among When relationships with several clinical variables (i.e., age, sex, age onset, number episode,...
This randomized, placebo-controlled study evaluated the efficacy and safety of a fixed dose (3 mg/day) flexible (3–15 schedule aripiprazole as augmentation therapy in Japanese patients with inadequate response to antidepressant (ADT). During an 8-week prospective treatment phase, experiencing major depressive episode received clinicians' choice ADT. Subjects ADT were randomized receive adjunctive placebo (n=195), (n=197) or (n=194) for 6 weeks. The primary endpoint was mean change...
Schizophrenia (SCZ) is a devastating psychiatric disorder with median lifetime prevalence rate of 0.7-0.8%. Elevated plasma total homocysteine has been suggested as risk factor for SCZ, and various biological effects hyperhomocysteinemia have proposed to be relevant the pathophysiology SCZ. As increased attention paid aberrant DNA methylation in attracting additional interest potential key substance. Homocysteine formed methionine cycle, which involved one-carbon methyl group-transfer...