Hai‐Gwo Hwu
A5038645756- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Mental Health Treatment and Access
- Mental Health and Psychiatry
- Bipolar Disorder and Treatment
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Genomics and Rare Diseases
- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Obsessive-Compulsive Spectrum Disorders
- Substance Abuse Treatment and Outcomes
- Tryptophan and brain disorders
- Personality Disorders and Psychopathology
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Healthcare Decision-Making and Restraints
- Psychosomatic Disorders and Their Treatments
- Epigenetics and DNA Methylation
- Alcohol Consumption and Health Effects
- Phosphodiesterase function and regulation
- Diet and metabolism studies
National Taiwan University Hospital
2015-2025
National Taiwan University
2014-2023
University of Utah
2023
Virginia Commonwealth University
2023
Huntsman (United States)
2023
Sartorius (United States)
2017-2019
Taipei Institute of Pathology
2019
National Yang Ming Chiao Tung University
2007-2018
National Science and Technology Council
2012
Taipei Medical University
1999
Background. There are few cross-national comparisons of the rates suicide ideation and attempts across diverse countries. Nine independently conducted epidemiological surveys using similar diagnostic assessment criteria provided an opportunity to obtain that data. Methods. Suicide were assessed on Diagnostic Interview Schedule in over 40000 subjects drawn from United States, Canada, Puerto Rico, France, West Germany, Lebanon, Taiwan, Korea New Zealand. Results. The lifetime prevalence...
ABSTRACT The Taiwan Psychiatric Epidemiological Project, conducted from 1982 to 1986, used the multistage random sampling method with 5005, 3004 and 2995 subjects selected respectively metropolitan Taipei (MT), 2 small towns (ST) 6 rural villages (RV). case identification tool was Chinese modified Diagnostic Interview Schedule (DIS‐CM). This study presents lifetime one‐year prevalence of 27 17 specific psychiatric disorders respectively. any disorder defined by DIS‐CM—excluding tobacco...
<h3>Background:</h3> Epidemiological data on panic disorder from community studies 10 countries around the world are presented to determine consistency of findings across diverse cultures. <h3>Method:</h3> Data independently conducted surveys (the United States, Canada, Puerto Rico, France, West Germany, Italy, Lebanon, Taiwan, Korea, and New Zealand), using Diagnostic Interview Schedule and<i>DSM-III</i>criteria including over 40 000 subjects, were analyzed with appropriate standardization...
Schizophrenia has been associated with abnormal task-related brain activation in sensory and motor regions as well social cognition network. Recently, two studies investigated temporal correlation between resting-state functional magnetic resonance imaging (R-fMRI) low-frequency oscillations (LFOs) schizophrenia but reported mixed results. This may be due to the different frequency bands used these studies. Here we utilized R-fMRI measure amplitude of fluctuations (ALFF) fractional ALFF...
Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are major source disability social economic burden. Both have substantial genetic etiology, partially shared distinct from that related psychiatric disorders.
Objective: The authors investigated whether nonpsychotic relatives of schizophrenic probands have an elevated risk deficits in sustained attention as measured by the Continuous Performance Test (CPT), such are associated with specific factors schizotypy, and poor CPT performance predicts their relatives. In addition, heritability families was estimated.Method: study subjects were 60 probands, 148 first-degree relatives, 20 normal comparison 42 probands' Subjects completed undegraded 25%...
Several groups have reported weak evidence for linkage between schizophrenia and genetic markers located on chromosome 22q using the lod score method of analysis. However these findings involved different methods analysis, so were not directly comparable. To resolve this issue we performed a combined analysis genotypic data from marker D22S278 in multiply affected schizophrenic families derived 11 independent research worldwide. This was chosen because it showed maximum three datasets...
The authors compared sustained attention deficits measured by the Continuous Performance Test in patients with various affective disorders and schizophrenia examined whether improve remission of disorder symptoms.Patients (N=41), major depression without psychotic features (N=22), bipolar (N=46) completed sessions an undegraded version test a 25% degraded which stimulus images were visually distorted. Subjects also interviewed Chinese Diagnostic Interview for Genetic Studies. All inpatients...
Since brain tissue is not readily accessible, a new focus in search of biomarkers for schizophrenia blood-based expression profiling non-protein coding genes such as microRNAs (miRNAs), which regulate gene by inhibiting the translation messenger RNAs. This study aimed to identify potential miRNA signature comparing genome-wide profiles patients with vs. healthy controls. A was performed using Taqman array 365 human miRNAs mononuclear leukocytes learning set 30 cases and The discriminating...
Genetic variation at two polymorphic alcohol dehydrogenase loci, ADH2 and ADH3, the mitochondrial aldehyde locus, ALDH2, may influence risk of developing alcoholism by modulating rate elimination ethanol formation acetaldehyde. Populations differ in allele frequencies these loci. We determined genotypes all three loci Atayal natives Taiwan. The ADH2′2, ADH3′1, ALDH2′1 alleles (0.91, 0.99, 0.95, respectively) were significantly higher among than a predominantly Han Chinese population from...
Prevalence and Determinants of Workplace Violence Health Care Workers in a Psychiatric Hospital Taiwan: Wen‐Ching C hen , et al . Yu‐Li Hospital, Department Health, Executive Yuan, Taiwan —Workplace violence, possible cause job stress, has recently become an important concern occupational health. This study determined the prevalence workplace violence its risk factors for employees at psychiatric hospital Taiwan. A questionnaire developed by ILO/ICN/WHO/PSI was first translated validated. It...
To examine the association between sleep-related problems and symptoms of attention-deficit/hyperactivity disorder (ADHD) in a community sample young adults Taiwan. A college-based cross-sectional survey. Two thousand two hundred eighty-four first-year college students (aged 18–20) university Each student completed questionnaire regarding sleep schedule (self-estimated total duration need), (dyssomnia, parasomnia, snoring), Chinese version Adult ADHD Self-Report Scale. Subjects were grouped...
Abstract People with schizophrenia are enriched for rare coding variants in genes associated neurodevelopmental disorders, particularly autism spectrum disorders and intellectual disability. However, it is unclear if the same changes to gene function that increase risk also do so schizophrenia. Using data from 3444 trios 37,488 disorder trios, we show within shared genes, de novo generally of functional category, specific observed ( P = 5.0 × 10 −6 ). The latter includes known be pathogenic...
The Continuous Performance Test (CPT) has been modified to be used widely as a potential vulnerability marker of schizophrenia. In genetic analyses schizophrenia, well-established norms for the CPT are essential in choosing suitable threshold classifying subjects affected or unaffected. this study, we investigated performance 115 adolescents and 345 adults, randomly sampled from community, on two sessions 1–9 (undegraded 25% degraded). results showed that an older age was associated with...