Dieter B. Wildenauer
A5089075288- Genetic Associations and Epidemiology
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Genetic Mapping and Diversity in Plants and Animals
- Schizophrenia research and treatment
- Receptor Mechanisms and Signaling
- Congenital heart defects research
- Bipolar Disorder and Treatment
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Genetic and phenotypic traits in livestock
- Bioinformatics and Genomic Networks
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Alcohol Consumption and Health Effects
- Asthma and respiratory diseases
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- 14-3-3 protein interactions
- Ion channel regulation and function
- Trace Elements in Health
- Hemoglobin structure and function
The University of Western Australia
2013-2024
Harry Perkins Institute of Medical Research
2005-2022
Massachusetts General Hospital
2019
Queen Elizabeth II Medical Centre
2017
Center for Clinical Research (United States)
2008
Royal Perth Hospital
2008
University of Bonn
1996-2004
Ludwig-Maximilians-Universität München
1981-2002
Philipps University of Marburg
2002
Harvard University Press
2001
Several groups have reported weak evidence for linkage between schizophrenia and genetic markers located on chromosome 22q using the lod score method of analysis. However these findings involved different methods analysis, so were not directly comparable. To resolve this issue we performed a combined analysis genotypic data from marker D22S278 in multiply affected schizophrenic families derived 11 independent research worldwide. This was chosen because it showed maximum three datasets...
In response to reported schizophrenia linkage findings on chromosomes 3, 6 and 8, fourteen research groups genotyped 14 microsatellite markers in an unbiased, collaborative (New) sample of 403–567 informative pedigrees per marker, the Original which produced each finding (the Johns Hopkins University 46–52 for 3 Medical College Virginia 156–191 chromosome 6). Primary planned analyses (New sample) were two-point heterogeneity lod score (lod2) tests (dominant recessive affected-only models),...
Abstract Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in OPRM1 , has been identified as a genome-wide significant association with OA and independently replicated. We applied genomic structural equation modeling to conduct GWAS of new Genetics Addiction Consortium (GENOA) data together published studies (Psychiatric Genomics Consortium, Million Veteran Program, Partners Health), comprising 23,367 cases effective sample size 88,114 individuals European...
<h3>Context</h3> Dopamine receptor–mediated pathways play critical roles in the mechanism of addiction. However, associations D<sub>2</sub>dopamine receptor gene (<i>DRD2)</i>with substance abuse are controversial. <h3>Objective</h3> To determine whether susceptibility sites resided at<i>DRD2.</i> <h3>Design</h3> Haplotype-based case-control analysis 2 distinct populations using 10 single nucleotide polymorphisms (SNPs) with heroin dependence. <h3>Setting</h3> Universities Mainz and Bonn,...
The orientation of bacteriorhodopsin in the purple membrane Halobacterium halobium has been studied by proteolytic degradation sheets, reconstituted vesicles, and whole cells, with following results: ( i ) Bacteriorhodopsin sheets is cleaved at a single site Pronase or trypsin; polypeptide segment about 15 amino acids lost from carboxyl end. Carboxypeptidase A sequentially releases end; tetrapeptide sequence -Ala-Ala-Thr-Ser(COOH) was tentatively deduced for this terminus. ii apomembrane,...
Abstract A common T→C polymorphism of the KIBRA gene has been recently associated with worse performance on tests episodic memory. This should aimed to determine whether older adults CC genotype (1) have memory than T‐allele carriers and, (2) are more likely express phenotype amnestic mild cognitive impairment (MCI). Our Cross‐sectional investigation 312 aged 50–89 years free dementia included genotyping rs17070145 and assessment Establish a Registry for Alzheimer's Disease (CERAD)....
The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the schizophrenia common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs).The family sample included 2,461 individuals from 631 pedigrees (581 in primary European-ancestry analyses). Association was tested for single SNPs genetic pathways. Polygenic scores based on results were predict case-control status Schizophrenia Psychiatric GWAS Consortium (PGC) data set,...
OBJECTIVE: An association between the 5-HTTLPR short variant polymorphism in promoter region of serotonin transporter gene and risk for alcohol dependence has been reported from case-control studies that are, however, prone to chance findings related artifacts population structure. The authors sought additional evidence this a family-based study. METHOD: Ninety-two alcohol-dependent probands their parents were tested nonrandom transmission alleles heterozygous affected probands. RESULTS:...