A5034723746- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Pharmacological Receptor Mechanisms and Effects
- Pain Mechanisms and Treatments
- Genetic Associations and Epidemiology
- Schizophrenia research and treatment
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Bipolar Disorder and Treatment
- Amino Acid Enzymes and Metabolism
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Pain Management and Opioid Use
- Ion channel regulation and function
- Forensic Toxicology and Drug Analysis
- Parkinson's Disease Mechanisms and Treatments
Kobe University
2016-2025
Tohoku University
2008-2022
Tokyo Metropolitan Institute of Medical Science
2009-2018
National Institute on Drug Abuse
1999-2016
New Mexico VA Health Care System
2016
Tokyo Institute of Psychiatry
2000-2014
University of Würzburg
2001-2014
Japan Science and Technology Agency
2013
Japanese Urological Association
2005-2011
National Institutes of Health
1997-2010
The role of dopamine in sleep regulation and mediating the effects wake-promoting therapeutics is controversial. In this study, polygraphic recordings caudate microdialysate measurements narcoleptic dogs revealed that antinarcoleptic compounds modafinil amphetamine increase extracellular a hypocretin receptor 2-independent manner. mice, deletion transporter (DAT) gene reduced non-rapid eye movement time increased wakefulness consolidation independently from locomotor effects. DAT knock-out...
Morphine produces analgesia at opiate receptors expressed in nociceptive circuits. mu, delta, and kappa receptor subtypes are circuits that can modulate nociception receive inputs from endogenous opioid neuropeptide ligands. The roles played by each subtype processing drug-free morphine-treated states have not been clear, however. We produced homologous, recombinant receptor, heterozygous homozygous knockout animals displayed approximately 54% 0% of wild-type levels mu expression,...
Cocaine and methylphenidate block uptake by neuronal plasma membrane transporters for dopamine, serotonin, norepinephrine. also blocks voltage-gated sodium channels, a property not shared methylphenidate. Several lines of evidence have suggested that cocaine blockade the dopamine transporter (DAT), perhaps with additional contributions from serotonin (5-HTT) recognition, was key to its rewarding actions. We now report knockout mice without DAT 5-HTT establish cocaine-conditioned place...
Cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET). reward/reinforcement has been linked to actions at DAT or blockade of SERT. However, knockouts neither DAT, SERT, NET reduce cocaine reward/reinforcement, leaving substantial uncertainty about cocaine's molecular mechanisms reward. Conceivably, the bases reward might display sufficient redundancy that either SERT be able mediate in other's absence. To test this...
The brain vesicular monoamine transporter (VMAT2) pumps neurotransmitters and Parkinsonism-inducing dopamine neurotoxins such as 1-methyl-4-phenyl-phenypyridinium (MPP + ) from neuronal cytoplasm into synaptic vesicles, which amphetamines cause their release. Amphetamines MPP each also act at nonvesicular sites, providing current uncertainties about the contributions of actions to in vivo effects. To assess amphetamine-induced locomotion, reward, sequestration resistance dopaminergic...
Thalamocortical neurons innervating the barrel cortex in neonatal rodents transiently store serotonin (5-HT) synaptic vesicles by expressing plasma membrane transporter (5-HTT) and vesicular monoamine (VMAT2). 5-HTT knock-out (ko) mice reveal a nearly complete absence of 5-HT cerebral immunohistochemistry, barrels, both at P7 adulthood. Quantitative electron microscopy reveals that ko affects neither density synapses nor length contacts layer IV. VMAT2 mice, completely lacking...
Antidepressant drugs produce therapeutic actions and many of their side effects via blockade the plasma membrane transporters for serotonin (SERT/SLC6A2), norepinephrine (NET/SLC6A1), dopamine (DAT/SLC6A3). Many antidepressants block several these transporters; some are more selective. Mouse gene knockouts provide interesting models possible chronic antidepressant treatments. To examine role monoamine in depression DAT, NET, SERT knockout (KO) mice wild-type littermates were studied forced...
<h3>Context</h3> Various factors are involved in the pathogenesis of schizophrenia. Accumulation advanced glycation end products, including pentosidine, results from carbonyl stress, a state featuring an increase reactive compounds (RCOs) and their attendant protein modifications. Vitamin B<sub>6</sub>is known to detoxify RCOs, products. Glyoxalase I (GLO1) is one enzymes required for cellular detoxification RCOs. <h3>Objectives</h3> To examine whether plasma levels pentosidine serum vitamin...
Opioids, such as morphine and fentanyl, are widely used effective analgesics for the treatment of acute chronic pain. In addition, opioid system has a key role in rewarding effects morphine, ethanol, cocaine various other drugs. Although sensitivity is well known to vary among individual subjects, several candidate genetic polymorphisms reported so far not sufficient fully understanding wide range interindividual differences human sensitivity. By conducting multistage genome-wide association...
The association between SNPs of the human OPRM1 gene encoding micro-opioid receptor and postoperative analgesic requirements in surgical patients remains controversial. Here, we evaluate whether any five tag (A118G, IVS2+G691C, IVS3+G5953A, IVS3+A8449G TAA+A2109G) representing four linkage disequilibrium blocks influences requirements.We studied 138 adult Japanese who underwent major open abdominal surgery under combined general epidural anesthesia received continuous analgesia with...
Context:We can improve understanding of human methamphetamine dependence, and possibly our abilities to prevent treat this devastating disorder, by identifying genes whose allelic variants predispose dependence.Objective: To find "methamphetamine dependence" identified each 2 genome-wide association (GWA) studies independent samples methamphetamine-dependent individuals matched controls.Design: Replicated GWA results in casecontrol studies.Setting: Japan Taiwan.Participants: Individuals with...
Individual differences in sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. Still controversial is whether the single nucleotide polymorphisms (SNPs) of human OPRM1 gene encoding mu-opioid receptor influence analgesic effects opioids. We examined associations between fentanyl and two SNPs, A118G IVS3+A8449G, 280 Japanese patients undergoing painful orofacial cosmetic surgery, including bone dissection. Regarding SNP exon 1, cold pressor-induced...
Interactions between δ-opioid receptors and morphine-preferring μ-opioid receptor subtypes have been suggested. Availability of transgenic knockout mice allows assessment roles in the analgesia produced by classical agonist [d-Pen2,d-Pen5]enkephalin (DPDPE) hot-plate tail-flick tests. DPDPE was dramatically reduced a gene-dose-dependent fashion. The induced this classic depends on intact receptors, suggesting that selective drugs may require occupancies for full efficacy.