A5044283342- Schizophrenia research and treatment
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Genetic Associations and Epidemiology
- Pharmacogenetics and Drug Metabolism
- Diet and metabolism studies
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Genomic variations and chromosomal abnormalities
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Effects and Toxicity Studies
- Cardiac electrophysiology and arrhythmias
- Genomics and Rare Diseases
- Attention Deficit Hyperactivity Disorder
- Epilepsy research and treatment
- Posttraumatic Stress Disorder Research
- Maternal Mental Health During Pregnancy and Postpartum
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Receptor Mechanisms and Signaling
- Disaster Response and Management
- Neuroscience and Neuropharmacology Research
- Obsessive-Compulsive Spectrum Disorders
- Drug Transport and Resistance Mechanisms
Niigata University
2016-2025
Niigata University Medical and Dental Hospital
2012-2023
Niigata Prefectural Central Hospital
2022
Japanese Society of Clinical Neuropsychopharmacology
2005-2020
Suzuki (Japan)
2019
International Union of Basic and Clinical Pharmacology
2014
Japan Society for the Promotion of Science
2011-2013
Niigata University of Health and Welfare
2011
Université de Montréal
2009
California State University, Long Beach
2007
Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs) autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 ASD cases, 2,458 SCZ 2,095 controls Japanese population confirmed an increased burden of rare exonic CNVs both disorders. Clinically significant (or pathogenic) CNVs, including those at 29 loci common to disorders, were found about 8% which was significantly higher than controls. Phenotypic analysis revealed association...
Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In present GWAS (Phase I/II), which included 2964 61 887 control subjects from Japanese population, we detected a novel locus at 11q12.2 (rs28456, P=6.4 × 10−9), region known contain regulatory genes plasma lipid levels (FADS1/2/3). A subsequent meta-analysis...
This study reports the first paired measurements of glucose metabolism and size thalamic regions in never-medicated schizophrenic patients using coregistered magnetic resonance imaging (MRI) templates.Positron emission tomography with [18F]fluorodeoxyglucose matching MRI scans were obtained 20 schizophrenia 15 normal volunteers. Methods for edge finding, statistical testing shape differences chi-square maps, localization major subregions developed.Patients showed a diminished metabolic rate...
Genome-wide association studies (GWASs) have identified >100 susceptibility loci for schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by numerous genetic variants but with small effect size. We conducted GWAS in the Japanese (JPN) population (a) to detect novel SCZ-susceptibility genes (b) examine shared risk of across (East Asian [EAS] European [EUR]) populations and/or trans-diseases (SCZ, bipolar [BD], major depressive [MDD]) within EAS between EUR...
The ability to infer others' mental states is essential social interactions. This ability, critically evaluated by testing whether one attributes false beliefs (FBs) others, has been considered be uniquely hominid and accompany the activation of a distributed brain network. We challenge taxon specificity this identify causal locus introducing an anticipatory-looking FB paradigm combined with chemogenetic neuronal manipulation in macaque monkeys. find spontaneous gaze bias macaques implicitly...
Abstract No instrument for assessing impulsiveness has been developed in Japan. After translating the Barratt Impulsiveness Scale 11th version (BIS‐11) into Japanese, we investigated reliability and validity student ( n = 34) worker 416) samples. To assess test–retest reliability, intraclass coefficient between test retest was calculated sample. Internal consistency examined by calculating Cronbach's alpha see factor validity, confirmatory analysis whether three‐factor model, proposed a...
Chromatin remodeling may play a role in the neurobiology of schizophrenia and process, therefore, be considered as therapeutic target. The SMARCA2 gene encodes BRM SWI/SNF chromatin-remodeling complex, associations single nucleotide polymorphisms (SNPs) to were found two linkage disequilibrium blocks after screening 11 883 SNPs (rs2296212; overall allelic P = 5.8 × 10−5) subsequent 22 genes involved chromatin (rs3793490; 2.0 10−6) Japanese population. A risk allele missense polymorphism...
Studies on HLA antigens were conducted in several patient populations with the following findings: (a) All 135 Japanese narcoleptic patients, eight of whom considered to have "symptomatic" narcolepsy, found be HLA-DR2 and HLA-DQw1 positive. 17 members a subgroup original population also HLA-Dw2-positive. It was concluded that is prerequisite for development narcolepsy diagnosis can excluded if or HLA-Dw2 negative. The distinction between idiopathic symptomatic needs reconsidered. (b)...
Aim: This study was undertaken 5 months after the 2004 Niigata–Chuetsu earthquake in Japan to assess factors that impacted on psychological distress and its recovery. Methods: Three thousand twenty‐six adult victims who lived temporary shelter seriously damaged areas were evaluated by questionnaire. The questionnaire queried subject profile, degree of house damage, health status, using a 5‐point scale before, immediately earthquake. Results: Immediately earthquake, 59.3% subjects had...
BackgroundWe aimed to determine the similarities and differences in roles of genic regulatory copy number variations (CNVs) bipolar disorder (BD), schizophrenia (SCZ), autism spectrum (ASD).MethodsBased on high-resolution CNV data from 8708 Japanese samples, we performed our knowledge largest cross-disorder analysis CNVs BD, SCZ, ASD.ResultsIn CNVs, found an increased burden smaller (<100 kb) exonic deletions which contrasted with highest larger (>500 SCZ/ASD. Pathogenic linked...
Abstract Many postsynaptic density proteins carrying density‐95/discs large/zone occludens‐1 (PDZ) domain(s) interact with glutamate receptors to control receptor dynamics and synaptic plasticity. Here we examined the expression of PDZ proteins, synapse‐associated protein (SAP) 97, (PSD)‐95, chapsyn‐110, GRIP1 SAP102, in post‐mortem brains schizophrenic patients subjects, evaluated their contribution pathology. Among these SAP97 exhibited most marked change: levels were decreased less than...
Abstract Recent progress in genotyping technology and the development of public databases has enabled large‐scale genome‐wide association tests with diseases. We performed a two‐stage study (GWAS) bipolar disorder (BD) Japanese cohorts. First we used Affymetrix 100K GeneChip arrays analysis 107 cases I controls, selected markers that were nominally significant ( P < 0.01) at least one three models (1,577 total). In follow‐up stage, analyzed these using an Illumina platform (1,526 markers;...
Background: Japan is located in an area prone to natural disasters, and major earthquakes have occurred recently rural areas where the proportion of elderly adults high. Although persons are vulnerable members communities at a time disaster, prevalence mental disorders among this population has yet be reported Japan. This study aimed determine suicidal thoughts community-dwelling 3 years after earthquake identify risk factors associated with their quality life (QOL).Methods: Face-to-face...