A5101463623- Genetic Associations and Epidemiology
- Cardiac Ischemia and Reperfusion
- Bipolar Disorder and Treatment
- Rocket and propulsion systems research
- Energetic Materials and Combustion
- Schizophrenia research and treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Adipose Tissue and Metabolism
- Plant Pathogens and Fungal Diseases
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Plant Physiology and Cultivation Studies
- Cardiac Imaging and Diagnostics
- Plant Pathogens and Resistance
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Plant Reproductive Biology
- Genomic variations and chromosomal abnormalities
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cerebrovascular and Carotid Artery Diseases
- Genomics and Rare Diseases
- Vestibular and auditory disorders
- Health Systems, Economic Evaluations, Quality of Life
- Wheat and Barley Genetics and Pathology
Fujita Health University
2016-2025
National Agriculture and Food Research Organization
2007-2022
Institute of Vegetable and Floriculture Science
1994-2022
Minami Kyushu University
2018
The University of Tokyo
1974-2014
Osaka University
2014
National Center for Global Health and Medicine
2014
Teikyo University
2014
University of Occupational and Environmental Health Japan
2014
Nagoya University
2014
Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In present GWAS (Phase I/II), which included 2964 61 887 control subjects from Japanese population, we detected a novel locus at 11q12.2 (rs28456, P=6.4 × 10−9), region known contain regulatory genes plasma lipid levels (FADS1/2/3). A subsequent meta-analysis...
Genome-wide association studies (GWASs) have identified >100 susceptibility loci for schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by numerous genetic variants but with small effect size. We conducted GWAS in the Japanese (JPN) population (a) to detect novel SCZ-susceptibility genes (b) examine shared risk of across (East Asian [EAS] European [EUR]) populations and/or trans-diseases (SCZ, bipolar [BD], major depressive [MDD]) within EAS between EUR...
Anthocyanins were detected in extracts from the peels of 123 accessions eggplant (Solanum melongena) and its related species. Their anthocyanin profiles classified into four types, including known Japanese type (type 1) non-Japanese 2). Although most had one two profiles, accession a novel profile 3). Two species showed another 4). The major anthocyanins identified as delphinidin 3-(p-coumaroylrutinoside)-5-glucoside (nasunin) 1), 3-rutinoside 2), 3-glucoside 3), petunidin (petunidin 3RGc5G)...
BackgroundWe aimed to determine the similarities and differences in roles of genic regulatory copy number variations (CNVs) bipolar disorder (BD), schizophrenia (SCZ), autism spectrum (ASD).MethodsBased on high-resolution CNV data from 8708 Japanese samples, we performed our knowledge largest cross-disorder analysis CNVs BD, SCZ, ASD.ResultsIn CNVs, found an increased burden smaller (<100 kb) exonic deletions which contrasted with highest larger (>500 SCZ/ASD. Pathogenic linked...
Abstract Large-scale genome-wide association studies (GWASs) on bipolar disorder (BD) have implicated the involvement of fatty acid desaturase ( FADS ) locus. These enzymes (FADS1 and FADS2) are involved in metabolism eicosapentaenoic (EPA) docosahexaenoic (DHA), which thought to potentially benefit patients with mood disorders. To model reductions activity FADS1/2 affected by susceptibility alleles, we generated mutant mice heterozygously lacking both Fads1 / 2 genes. We measured...
An experimental model that induces sustained ischemia and infarction may provide useful information relevant to prevention of the development ischemic brain disease. The purpose present study was elucidate pathophysiological consequences cerebral blood flow under or oligemia in rats after microsphere embolism. We injected 900 microspheres (48 microns diameter) into right internal carotid artery 146 determined time course changes cortex, striatum, hippocampus both hemispheres by hydrogen...
This pharmacovigilance study evaluated the profile of clozapine-related adverse events by region using Food and Drug Administration Adverse Event Reporting System (FAERS).
Among antipsychotics, clozapine is associated with a high risk of seizures. This study aimed to generate novel hypotheses regarding trends in the onset clozapine-induced seizures using JADER (Japanese Adverse Drug Event Report) database. Seizures were defined according Standardized MedDRA Queries (SMQ) for convulsions (SMQ20000079). Trends assessed multivariate logistic regression analysis covariates sex, age, dose, antipsychotic polypharmacy, concomitant medications, and history convulsive...
<title>Abstract</title> Background Gene-environment interactions may enhance our understanding of hypertension. Our previous study highlighted the importance considering psychosocial factors in gene discovery for blood pressure (BP) but was limited statistical power and population diversity. To address these challenges, we conducted a multi-population genome-wide association (GWAS) BP accounting gene-depressive symptomatology (DEPR) larger more diverse sample. Results included 564,680 adults...
Suicidal ideation (SI) and behavior (SB) are major public health concerns, but risk factors for their development progression poorly understood. We used ICD codes a natural language processing algorithm to identify individuals in hospital biobank with SI-only, SB, controls without either. compared the profiles of SB SI-only patients controls, each other, using phenome-wide association studies (PheWAS) polygenic scores (PRS). PheWAS identified many plus specific psychiatric disorders which...
Background Although several guidelines provide dosing recommendations for antidepressants based on patients’ genetic information, pharmacogenetic testing antidepressant use is rarely routinely performed in Japan. To clarify the clinical impact of testing, this study estimated potential drug-gene interactions first-time treatment Japanese patients with major depressive disorder. Methods This retrospectively included who were registered episodes (F32, International Classification Diseases,...
Objective: The purpose of the present study was to examine effects preconditioning on glycolysis and oxidative phosphorylation during reperfusion in perfused rat hearts. Methods: Preconditioning induced by 5 min ischemia before 40 sustained subsequent 30 reperfusion. Tissue energy metabolite levels, mitochondrial oxygen consumption capacity adenine nucleotide translocator content hearts were assessed at ischemia, Results: improved postischemic recovery rate X pressure product (92.5 ± 8.7 vs....
Schizophrenia (SZ) and bipolar disorder (BD) have been known to share genetic environmental risk factors, complex gene-environmental interactions may contribute their pathophysiology. In contrast high overlap between SZ BD, as revealed by genome-wide association studies, the extent of epigenetic remains largely unknown. present study, we explored whether BD factors in same manner they components.We performed DNA methylation analyses CpG sites top five candidate regions (FAM63B, ARHGAP26,...
Recent genome-wide association studies (GWASs) of schizophrenia (SCZ) identified several susceptibility genes and suggested shared genetic components between SCZ bipolar disorder (BD). We conducted a study single nucleotide polymorphisms (SNPs) selected according to previous GWAS targeting psychotic disorders (SCZ BD) in the Japanese population. Fifty-one SNPs were analyzed two-stage design using first-set screening samples (all SNPs: 1,032 SCZ, 1,012 BD, 993 controls) second-set replication...
A core collection of eggplant (Solanum melongena L.) was developed based on a dataset genome-wide 831 SNP and 50 SSR genotypes analyzed in 893 accessions genetic resources collected the NARO Genebank using Core Hunter II program. The were worldwide, mainly Asia. Genetic variation population structure among characterized. diversity Asian accessions, especially South Southeast forming center eggplant, higher than that other regions. resulting collection, World Eggplant (WEC) consisted 100...
Using an improved method for evaluating powdery mildew (Sphaerotheca cucurbitae) resistance in cucumber, experiments were conducted the breeding of varieties resistant to that would be adapted greenhouse cultivation during period from winter spring Japan. The relationship between pathogen and ambient temperature was analyzed by spray inoculation a conidial suspension under controlled conditions. Although varieties, Asomidori-5-gou Natsufushinari at temperatures 25 30ºC, they became...