A5057097256- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Drug Transport and Resistance Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Ion Transport and Channel Regulation
- Psychosomatic Disorders and Their Treatments
- Renal Transplantation Outcomes and Treatments
- Tryptophan and brain disorders
- Plasma Applications and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Obsessive-Compulsive Spectrum Disorders
- Pancreatic function and diabetes
- Hemoglobin structure and function
- Glycosylation and Glycoproteins Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- thermodynamics and calorimetric analyses
- Genetics, Aging, and Longevity in Model Organisms
- Fungal Infections and Studies
- Air Quality Monitoring and Forecasting
- Youth Substance Use and School Attendance
- Genetic Associations and Epidemiology
- Long-Term Effects of COVID-19
National Center of Neurology and Psychiatry
2021-2025
National Institute of Mental Health
2021-2025
Ochanomizu University
2021-2024
Kochi University of Technology
2015-2017
Japan Science and Technology Agency
2012
National Institute of Health Sciences
2012
Kanazawa University Hospital
2008-2012
National Institute of Infectious Diseases
2012
Kanazawa University
2005-2006
Human organic anion transporting polypeptide OATP-B (OATP2B1) is a pH-sensitive transporter expressed in the apical membranes of small intestinal epithelial cells. In this study, we have examined contribution to uptake [<sup>3</sup>H]estrone-3-sulfate Caco-2 cells comparison with those its homologs OATP-D (OATP3A1) and OATP-E (OATP4A1). Immunocytochemical study revealed that The by was Na<sup>+</sup>-independent inhibited several anions. It showed biphasic saturation kinetics...
Cold atmospheric plasmas have attracted significant worldwide attention for their potential beneficial effects in cancer therapy. In order to further improve the effectiveness of plasma therapy, it is important understand generation and transport reactive species into tissue fluids, tissues cells, moreover rates depths delivery, particularly across physical barriers such as skin. this study, helium (He) jet treatment a 3D tumour, grown on back live mouse, induced apoptosis within tumour...
Abstract According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive (MDD), and autism spectrum (ASD) are classified based on symptoms. While its cluster of symptoms defines each these disorders, there is also an overlap in between disorders. We hypothesized that similarities differences cortical structural neuroimaging features among T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects...
Glycosylphosphatidylinositol (GPI)-anchor attachment is one of the most common posttranslational protein modifications. Using nematode Caenorhabditis elegans, we determined that GPI-anchored proteins are present in germline cells and distal tip cells, which essential for maintenance stem cell niche. We identified 24 C. elegans genes involved GPI-anchor synthesis. Inhibition various steps synthesis by RNA interference or gene knockout resulted abnormal development oocytes early embryos, both...
The helium (He) atmospheric-pressure plasma jet (APPJ) delivery of reactive oxygen and nitrogen species (RONS) molecular (O2) in deionized (DI) water was monitored real time using situ UV absorption spectroscopy. He APPJ used to treat DI directly through an agarose target as a surrogate for tissue (e.g., skin barrier). For direct treatment, the RONS were generated immediately water, concentration continued increase during treatment. But there only very minor total detected after gas flow...
Abstract Establishing a brain biomarker for schizophrenia is strongly desirable not only to support diagnosis by psychiatrists but also help track the progressive changes in over course of illness. A morphological signature was reported recent study and defined clusters regions with reduced volume patients compared healthy individuals. This proven be effective at differentiating from individuals, suggesting that it good candidate schizophrenia. However, longitudinal characteristics this have...
ABSTRACT Schizophrenia causes cognitive dysfunction. The assessment of function is important in the treatment schizophrenia. Wechsler Adult Intelligence Scale (WAIS) used to assess patients with psychiatric disorders. For clinical use, a short form WAIS‐III was developed Japan specifically for schizophrenia, allowing estimation IQ using Similarities and Symbol Search. In present study, we examined whether same tasks could be on WAIS‐IV. subjects were 110 Using methods consistent those...
Abstract Background The creation of a novel diagnostic system using objective biomarkers is expected to take place, due difficulty the current based on symptoms in psychiatry. Aims & Objectives We clustered 5602 subjects brain subcortical volumes and showed four-biotype classification, namely extremely (Brain Biotype [BB] 1: n=110) moderately smaller limbic regions (BB2: n=566), larger basal ganglia (BB3: n=679), normal (BB4: n=4247), being associated with cognitive/social functioning...
ABSTRACT One of the challenges in diagnosing psychiatric disorders is that results biological and neuroscience research are not reflected diagnostic criteria. Thus, data‐driven analyses incorporating cross‐disease perspectives, regardless category, have recently been proposed. A clustering study based on subcortical volumes 5604 subjects classified into four brain biotypes associated with cognitive/social functioning. Among identified controls patients schizophrenia, bipolar disorder, major...
Memory function impairment is severe in patients with schizophrenia, but improving memory remains challenging. The use of benzodiazepines and anticholinergics, which are not recommended by pharmacological therapy guidelines for has been associated worsened cognitive function. However, it unclear whether better adherence psychiatrists to schizophrenia improved Therefore, we investigated the relationship between psychiatrists' schizophrenia. To evaluate associations function, utilized...
Negative symptoms and social function have been known to predict work outcomes in patients with schizophrenia. Recent studies report that specific subdomains of these predictors were particularly important prediction. The aims this study (1) determine which negative the most among schizophrenia, (2) use factors produce charts demonstrate estimated probabilities workable hours. Data obtained from 293 Four separate logistic regression analyses conducted using psychiatric symptoms, intellectual...
Clinician adherence to guideline recommendations in the pharmacological therapy of schizophrenia is important for favorable patient outcomes. To evaluate whether prescriptions followed guidelines schizophrenia, we recently developed a summary indicator multiple quality indicators: individual fitness score (IFS). It unclear related Here, investigated correlations between IFS values and psychotic symptoms patients with schizophrenia.We assessed patients' current adhered using 47...
Changes of mycophenolic acid (MPA) pharmacokinetics with aging were investigated in rats. We also compared the effect concomitant amoxicillin/clavulanate combination (CVA/AMPC) on MPA 4-week-old and 12-week-old rats (the package insert CVA/AMPC warns possible interaction MPA). Four-week-old showed a 1.4-fold higher total body clearance lower volume distribution (65%), to values However, difference disappeared when enterohepatic circulation was eliminated by bile duct cannulation (BDC)....
Background Schizophrenia is a complex mental disorder characterized by significant cognitive and neurobiological alterations. Impairments in function eye movement have been known to be promising biomarkers for schizophrenia. However, assessment methods require specialized expertise. To date, data on simplified measurement tools assessing both patients with schizophrenia are lacking. Objective This study aims assess the efficacy of novel tablet-based platform combining measures classifying...
Abstract The trough level of blood concentration cyclosporin A (CyA) in a patient receiving immunotherapy was observed to decrease following coadministration amphotericin B (AMB). This clinical observation confirmed experimentally Wistar rats intravenously given AMB (1.5 or 3.0 mg/kg) saline (control) for 4 days, followed by CyA (10 mg/kg). after i.v. p.o. administration both groups significantly decreased compared with the control. oral bioavailability 1.5 mg/kg treatment 67% 46%,...
Abstract Aim Social functioning is influenced by various factors. Autistic traits could be one of the factors that affect social functioning. Methods In present study, relationship between autistic and among 755 healthy individuals was analyzed. were assessed with autism‐spectrum quotient. scale activity assessment. Results The Autism‐Spectrum Quotient total score significantly negatively correlated all subscales scale. All except attention to detail score. However, not assessment, which...
Abstract Schizophrenia is a psychiatric disorder that associated with various social dysfunctions, including shorter work hours. To measure the degree to which psychiatrists adhere guidelines for pharmacological therapy of schizophrenia, we recently developed individual fitness score (IFS) adherence among in each patient. However, it remains unclear whether better higher patients’ functional outcomes, such as In this study, examined relationship between and hours patients schizophrenia....
Patients with schizophrenia can exhibit intelligence decline, which is an important element of cognitive impairment. Previous magnetic resonance imaging (MRI) studies have demonstrated that patients altered gray matter structures and functional connectivity associated decline defined by a difference between premorbid current quotients (IQs). However, it has remained unclear whether white microstructures are related to decline. In the present study, indices diffusion tensor (DTI) obtained...
The purpose of this study was to investigate whether the trough plasma concentration voriconazole (VRCZ) in steady-state (Cmin) influences efficacy and safety adult pediatric patients.Treatment successful 75% patients 56% patients,and there no association between Cmin efficacy.However,liver dysfunction occurred more frequently case that over 4μg/mL both patients.Also,pediatric patients,especially those younger than 2 years,required a higher dose VRCZ adults achieve similar Cmin.We concluded...
Abstract Aims Schizophrenia is a psychiatric disorder presenting lack of insight. Although insight changes over time, longitudinal studies in schizophrenia are scarce. Furthermore, most previous on and intelligence have not measured full‐scale IQ been able to examine the relationship between detailed dimensions cognitive function In this study, we assessed at two time points function. Methods A total 163 patients with participated study. We evaluated understand patterns change examined...