A5101613600- Aquaculture Nutrition and Growth
- Reproductive biology and impacts on aquatic species
- Cardiac Imaging and Diagnostics
- Fish Biology and Ecology Studies
- Physiological and biochemical adaptations
- Cardiac Ischemia and Reperfusion
- Coronary Interventions and Diagnostics
- Fish Ecology and Management Studies
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Marine and fisheries research
- Cardiomyopathy and Myosin Studies
- Acute Myocardial Infarction Research
- Aquaculture disease management and microbiota
- Cardiac Fibrosis and Remodeling
- Marine Bivalve and Aquaculture Studies
- Healthcare and Environmental Waste Management
- Nitric Oxide and Endothelin Effects
- Cardiac Valve Diseases and Treatments
- Toxic Organic Pollutants Impact
- Cardiac Arrest and Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Lymphoma Diagnosis and Treatment
- Viral Infections and Immunology Research
- Syphilis Diagnosis and Treatment
Eli Lilly (Japan)
2022-2025
Kyushu University
2025
Tokyo Metropolitan Komagome Hospital
2018-2024
Osaka Red Cross Hospital
2011-2023
Hakodate Central General Hospital
2021-2023
University of Yamanashi Hospital
2023
Juntendo University
1989-2021
Kyoto University
2001-2018
Tokyo Women's Medical University Adachi Medical Center
2016
Tenri Hospital
2014
Markers of cardiac injury, including troponin-T (TnT), are used to diagnose acute coronary syndrome (ACS); however, markers for plaque instability may be more useful diagnosing ACS at the earliest stage. Lectin-like oxidized LDL receptor-1 (LOX-1) appears play crucial roles in pathogenesis atherosclerotic rupture and onset. LOX-1 is released part as soluble (sLOX-1) by proteolytic cleavage.We examined serum sLOX-1 levels 521 patients, consisting 427 consecutive patients undergoing...
As a first step for field applications of stable isotope techniques to investigate the migration Japanese temperate bass (Lateolabrax japonicus) (Perciformes) juveniles, we conducted diet switch experiment and fitted an exponential model changes in carbon (δ 13 C) nitrogen 15 N) ratios muscle, fin, liver. The trophic enrichment values were ranked liver < muscle fin δ C (range 0.80 +3.66) N (+0.59 +3.12). half-life similar both (19.325.7 days), while those 5.3 days 14.4 N. Both...
Objective: Ischaemic preconditioning may be mediated by oxygen free radicals generated during preconditioning. Conflicting results have been reported regarding the effect of superoxide dismutase (SOD) in attenuating cardioprotective The aim study was to reconcile this conflict examining three different oxyradical scavengers on infarct size limiting preconditioning, Methods: Anaesthetised open chest rabbits were subjected 30 min coronary occlusion and 48 h reperfusion. In groups, a single 5...
Late adverse events such as very late stent thrombosis (VLST) or target-lesion revascularization (TLR) after first-generation sirolimus-eluting stents (SES) implantation have not been yet fully characterized at long term in comparison with those bare-metal (BMS) implantation.Among 13 058 consecutive patients undergoing first percutaneous coronary intervention the Coronary REvascularization Demonstrating Outcome study-Kyoto registry Cohort-2, 5078 were treated SES only, and 5392 BMS only....
ABSTRACT Changes in chloride cell morphology were examined the yolk-sac membrane of Mozambique tilapia (Oreochromis mossambicus) embryos and larvae transferred from fresh water to sea water. By labelling cells with DASPEI, a fluorescent probe specific for mitochondria, we observed vivo sequential changes individual by confocal laser scanning microscopy. In 3 days after fertilization, 75 % survived 96 h, showed remarkable increase size. contrast, size did not change kept The same rate...
BACKGROUND Polymorphonuclear neutrophils (PMNs) accumulate in postischemic myocardium and may cause injury to or vessels by production of oxygen free radicals release proteases lipases. PMN accumulation is dependent on adherence endothelium, which mediated a family glycoproteins the surface, each has common beta-subunit (CD18). The purpose this study was determine whether an antibody (IB4) against CD18 protein could attenuate limit myocardial infarct size. METHODS AND RESULTS F(ab')2...
Pacific bluefin tuna larvae (Thunnus thynnus) were experimentally reared from 2-day-old yolk-sac through 30-day-old early juveniles in June and July 1994. The initially fed on rotifers Day 3 Artemia nauplii, fish eggs around 13, thereafter an artificial diet. had transformed to the juvenile stage after 30 days. primitive digestive system differentiated 3. gastric gland pyloric caeca first appeared 11 14, respectively. pharyngeal jaw teeth became fully functional with differentiation. number...
Hemorrhagic acute myocardial infarction (AMI) was studied after selective intracoronary thrombolysis (SICT) in 30 patients undergoing autopsy. Urokinase, 240,000 to 1,200,000 U, selectively injected into the infarct-related coronary artery at 2 9 hr (4 +/- hr) onset of AMI. The showed complete occlusion 21, 99% stenosis eight, and 90% one patient before SICT. After SICT, seen only five, 22, three patients. Twenty-eight had transmural other two subendocardial infarction. Macroscopically...
During metamorphosis and settlement the digestive system of Japanese flounder (Paralichthys olivaceus) exhibits various morphological features that include: differentiation development gastric glands pyloric caeca coupled with partial degradation pancreas; involution liver; inflation gall bladder; shortening gut epithelium height. Pepsin‐like enzyme activity increases markedly as proceeds, while trypsin‐like amylase activities drop significantly. High percentage newly settled wild at climax...
Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in atherosclerotic plaque vulnerability. It shed, part, by proteases and released as soluble LOX-1 (sLOX-1), which a specific sensitive biomarker of acute coronary syndrome (ACS). The present study explored if sLOX-1 can also predict prognosis after ACS. Methods Results: ACS patients undergoing emergency percutaneous intervention measurement circulating were followed (median: 896 days). Among 94...
Aim: Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signalling, is novel therapeutic target for type 2 diabetes mellitus. We evaluated in vitro and vivo the pharmacological profiles new PTP1B inhibitor, JTT‐551: monosodium ({[5‐(1,1‐dimethylethyl)thiazol‐2‐yl]methyl} {[(4‐{4‐[4‐(1‐propylbutyl)phenoxy]methyl}phenyl)thiazol‐2‐yl]methyl}amino)acetate. Methods: inhibitory activity inhibition mode were assayed with p ‐nitrophenyl phosphate as substrate, selectivity...
In Japanese flounder (Paralichthys olivaceus), metamorphic period involves not only transformation from larva to juvenile but also migration offshore areas estuaries. the present study, role of endocrine systems in low-salinity adaptation was examined during early development and metamorphosis flounder. Survival rate 48 hr after transfer 1/8 SW relatively high yolk-sac larvae, decreased gradually 0% at premetamorphosis, increased 100% climax. The ratio prolactin (PRL)-immunoreactive part...
Abstract Endothelin-1, a potent vasoconstrictor produced by vascular endothelial cells, activates the hypertrophic program in cultured heart muscle cells. However, role of endothelin-1 cardiac hypertrophy humans is unknown. Therefore, we studied cardiomyopathy patients with normal pulmonary arterial pressure, whom specific feature disease. Radioimmunoassay monoclonal antibody to human showed that plasma level immunoreactive endothelin was more than twofold higher control subjects ( P...
The developmental sequence of chloride cells was examined in both the body skin and gills Japanese flounder (Paralichthys olivaceus) larvae by whole-mount immunocytochemistry using an antiserum specific for Na(+),K(+)-ATPase. In premetamorphic at 0 4 days after hatching (days 4), immunoreactive were distributed only yolk-sac membrane skin. Premetamorphic 8-18 possessed cutaneous branchial cells. Large often formed multicellular complexes, suggestive their ion-secreting function. Cutaneous...