A5086182020- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Terahertz technology and applications
- Gyrotron and Vacuum Electronics Research
- Ocular Diseases and Behçet’s Syndrome
- Photoreceptor and optogenetics research
- Retinal and Macular Surgery
- Spectroscopy and Laser Applications
- Neurogenesis and neuroplasticity mechanisms
- Photochromic and Fluorescence Chemistry
- Cerebral Venous Sinus Thrombosis
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Semiconductor materials and devices
- Superconducting and THz Device Technology
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Systemic Sclerosis and Related Diseases
- Ferroelectric and Negative Capacitance Devices
- Semiconductor Quantum Structures and Devices
- Electronic and Structural Properties of Oxides
- Infectious Disease Case Reports and Treatments
Hokkaido University
2023-2025
Adeka (Japan)
2025
Kurashiki Central Hospital
2025
Shizuoka University
2024-2025
Kyoto Prefectural University of Medicine
2022-2024
Kobe City Medical Center General Hospital
2010-2022
Fukuoka University
2015-2021
Osaka University
2007-2013
Japan Science and Technology Agency
2013
Foundation for Biomedical Research and Innovation
2007
We previously reported that Otx2 is essential for photoreceptor cell fate determination; however, the functional role of in postnatal retinal development still unclear although it has been to be expressed bipolar cells and photoreceptors at stages. In this study, we first examined roles terminal differentiation by analyzing Otx2; Crx double-knockout mice. Otx2+/-; Crx-/- retinas, degeneration downregulation photoreceptor-specific genes were much more prominent than suggesting a...
We present experimental and numerical results on the propagation energy deposition of laser-generated fast electrons into conical targets. The first part reports measurements performed in various configurations order to assess predicted benefit targets over standard planar ones. For conditions investigated here, electron-induced heating is found be much weaker cone-guided irradiated at a laser wavelength 1.057μm, whereas frequency doubling pulse permits us bridge disparity between This...
To investigate when and how fast the foveal thinning occurs in central serous chorioretinopathy.Outer nuclear layer (ONL) thickness was measured 60 eyes of patients with active chorioretinopathy. Patients were divided into 3 groups based on duration symptoms; within 1 month (Group A, 25 eyes), to 6 months B, 17 >6 C, 18 eyes). Outer visual acuity compared between each group. Some underwent several examinations serial changes analyzed.The ONL correlated symptoms (R = -0.61, P < 0.001). Visual...
Seventy-nine adult patients with primary open-angle glaucoma (POAG) were randomly assigned to treatment by modified trabeculotomy ab externo (TAB) (n = 44) and trabeculectomy adjunctive mitomycin C (TMC) 35), the postoperative outcomes achieved these two techniques compared. With TAB, probability of successful intraocular pressure control 1 year postoperatively was .8644; TMC, .8432; difference is not significant (P .7956). However, complications such as corneal epithelial damage, bleb...
The photoreceptor is a highly polarized neuron and also has epithelial characteristics such as adherens junctions. To investigate the mechanisms of polarity formation cells, we conditionally knocked out atypical protein kinase Cλ ( aPKC λ), which been proposed to play critical role in establishment neuronal polarity, differentiating cells using Cre-loxP system. In λ conditional knock-out (CKO) mice, displayed morphological defects failed form ribbon synapses. Intriguingly, lack...
Purpose. Anti-vascular endothelial growth factor (VEGF) therapy is a first-line treatment for age-related macular degeneration (AMD) but frequent visits and injections can be burden patients. The purpose of this study to estimate the remission rate tolerability anti-VEGF AMD in clinical setting. Methods. We investigated 90 eyes 87 patients with who underwent were followed more than 6 months. Ranibizumab pegaptanib used as agents. Initial was any following: single injection, 3 consecutive...
We have demonstrated frequency up-conversion in the terahertz (THz) region by flash ionization, which occurs due a wave interacting with plasma created an ultrashort laser pulse. The upshift is controlled density. performed proof-of-principle experiment creation time scale much shorter than period of electromagnetic and length longer its wavelength. upshifted from 0.35 to 3.5 THz irradiating ZnSe crystal Ti:sapphire
To determine the prevalence and annual trend of number incident cases myopia high in children. A nationwide, comprehensive claims database study. Of 15 million children aged ≤14 years, those covered by universal health insurance were included. The validation study claims-based definitions was conducted using 14 654 individuals years recruited from 11 diverse medical facilities. This comprises a national analysis multicenter Data National Database Health Insurance Claims Specific Checkups...
An HfxZr1–xO2 (HZO) thin film is a promising material for next-generation ferroelectric memory devices. Ferroelectric HZO films are industrially produced using the atomic layer deposition (ALD) technique. However, conventional ALD precursors ZrO2 exhibit lower thermal stability than those HfO2; thus, temperature limited by Zr precursor processing (320 °C), limiting quality of HZO. In this study, we developed an HZO: liquid homoleptic cocktail referred to as FER-1, which composed...
The maintenance of aged city infrastructure is one the severe monetary and labor-cost-consuming problems. To tackle this problem, we have been investigating sewer pipe inspection using multiple UAVs. In system, a multi-hop wireless network established within leading UAV, which equipped with camera, transmits video data to control node on ground via relay UAVs LAN. our previous work, proposed packet transmission scheduling method for both UAV commands based Bi-IPT protocol carried out...
Objectives Erythropoietin (EPO) exerts tissue‐protective effects on various organs including the kidney. However, of EPO established renal fibrosis remain unclear. In this study, we aimed to examine therapeutic potential against fibrosis. Methods Renal was induced in mice by unilateral ureteral obstruction (UUO) and were treated with recombinant human (rhEPO) daily during 7 13 days after UUO. The degrees fibrosis, myofibroblast accumulation, macrophage infiltration; mRNA expression levels...