A5052081532- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Intracerebral and Subarachnoid Hemorrhage Research
- Organophosphorus compounds synthesis
- Synthesis of Organic Compounds
- Acute Ischemic Stroke Management
- Traffic Prediction and Management Techniques
- Dermatological and Skeletal Disorders
- Dermatology and Skin Diseases
- Phytochemistry and Biological Activities
- Retinopathy of Prematurity Studies
- Advancements in Transdermal Drug Delivery
- Transportation Planning and Optimization
- Ophthalmology and Eye Disorders
- Ocular Infections and Treatments
- Human Mobility and Location-Based Analysis
Kyoto University
2016-2025
Toshiba (Japan)
2014-2024
Purpose: To evaluate the efficacy and safety of faricimab injections for treatment-naïve neovascular age-related macular degeneration (nvAMD) patients, including subtypes pachychoroid phenotypes, identify predictive factors visual outcomes. Methods: nvAMD patients were prospectively recruited, receiving three monthly (6 mg) injections. Best-corrected acuity (BCVA) two months after last injection (month 4) was compared between subtypes, neovasculopathy (PNV) non-PNV eyes. Regression analysis...
Aims The aim of this study was to elucidate the epidemiological background central serous chorioretinopathy (CSC), including its incidence and treatment pattern. Methods This a population-based longitudinal cohort using nationwide health insurance claims database Japan Ministry Health, Labour Welfare (MHLW). As employs universal coverage, covers more than 95% issued in Japan. We accessed all data stored with permission from MHLW. traced individuals aged 30 years or older identified new onset...
Abstract Though vascular endothelial growth factors (VEGF) and other proangiogenic factors, such as angiopoietins (Ang), may be involved in the development of neovascular age-related macular degeneration (nvAMD), only drugs that inhibit VEGF family are available for treatment. The newly approved anti-VEGF drug faricimab, which also inhibits Ang-2, is expected to effective patients with AMD refractory conventional drugs. Therefore, we prospectively investigated efficacy faricimab treatment...
Aims The latest evidence in the incidence of central retinal artery occlusion (CRAO) is needed to support development novel treatments as orphan drugs. However, up-to-date information on CRAO ageing or aged population limited. We aimed investigate nationwide epidemiological and clinical characteristics Japan, using health insurance claims data. Methods analysed a total 16 069 762 data sampling dataset National Database Health Insurance Claims Specific Checkups Japan (NDB), which database 127...
To determine the prevalence and annual trend of number incident cases myopia high in children. A nationwide, comprehensive claims database study. Of 15 million children aged ≤14 years, those covered by universal health insurance were included. The validation study claims-based definitions was conducted using 14 654 individuals years recruited from 11 diverse medical facilities. This comprises a national analysis multicenter Data National Database Health Insurance Claims Specific Checkups...
To elucidate the incidence and treatment pattern of active exudative age-related macular degeneration (AMD).A population-based cohort study conducted using National Database Health Insurance Claims Specific Checkups Japan (NDB), a national claims database managed by Japanese Ministry Health, Labour, Welfare (MHLW).The entire population aged 40 years or older (76 million people).With permission MHLW, we accessed complete NDB dataset identified patients with newly diagnosed AMD between 2011...
Abstract Background The morphology and content of stratum corneum (SC) cells provide information on the physiological condition skin. Although morphological biochemical properties SC are known, no method is available to fully access interpret this information. This study aimed develop a comprehensively decode skin, based SC. Therefore, we established novel image analysis technique artificial intelligence (AI) multivariate predict skin conditions. Materials Methods samples were collected from...
A scientific evaluation index system for intelligent transportation (ITS) can play an important role in guiding the development of ITS decision makers smart communities. This study aims to develop a set performance indicators effective community China. The main goals developed are determined after careful review various systems implemented by agencies worldwide. divided into following six categories then presented: transport structure, traffic information service, efficiency, safety, energy...
To investigate the prevalence and incidence of strabismus in Japanese population by age group to estimate subtype proportions.
Patients with Behcet's disease frequently have abnormal focal outer plexiform layer (OPL) bumps, which compress the inner nuclear layer. This study investigates clinical relevance of these OPL elevations in patients.Thirty-one consecutive patients (59 eyes) remission and available optical coherence tomography (OCT) images were included. The number bumps was counted using spectral-domain OCT images. relationships between visual acuity (VA), retinal thickness, choroidal duration, prior ocular...
We aimed to describe the epidemiology of angioid streaks (AS) and pseudoxanthoma elasticum (PXE), which are rare diseases, using a national claims database.This was population-based longitudinal cohort study.A total 126 million individuals were covered by universal health coverage system in Japan.With permission from Ministry Health, Labor Welfare, we accessed all data National Database Health Insurance Claims Specific Checkups Japan, contains nationwide insurance for Japanese. identified...
This study aimed to analyze the trends and factors influencing number of ophthalmic surgeries in Japan using open data from National Database Health Insurance Claims Specific Checkups published by Ministry Health, Labour Welfare. We calculated cataract, glaucoma, vitreoretinal surgeries, categorized sex, age, surgical type, for fiscal years (FY) 2014 2020. The cataract remained stable at approximately 1.45 million cases FY 2018, increased nearly 1.6 2019, decreased Among glaucoma treatments...
To investigate the 10-year visual outcome and chorioretinal atrophy after a single intravitreal ranibizumab injection followed by pro re nata regimen for myopic macular neovascularization in pathologic myopia, to identify factors associated with best-corrected acuity (BCVA).This retrospective observational study evaluated 26 consecutive treatment-naïve eyes (26 patients) myopia who underwent of and/or aflibercept observed over 10 years. We assessed changes BCVA morphological parameters,...
Investigations of morphological changes in photoreceptors Behçet's disease (BD) using adaptive optics scanning light ophthalmoscope (AOSLO) are lacking. The authors aimed to evaluate macular cone density and regularity BD patients with or without a history uveitis good visual acuity (VA).The included 16 (29 eyes) 12 healthy volunteers (12 as controls. All subjects had VA 20/20 higher. Subjects underwent AOSLO the photoreceptor status including (numbers/mm2) proportion hexagonal Voronoi...
To investigate factors associated with 3-month or 1-year best-corrected visual acuity (BCVA) after vitrectomy subretinal tissue plasminogen activator injection for submacular hemorrhage (SMH) and to identify the predictors of early displacement.This prospective cohort study included consecutive eyes SMH complicating neovascular age-related macular degeneration retinal macroaneurysm that underwent were followed up at least 3 months. Parameters correlated BCVA, 2-week displacement grade (0-3)...
Abstract This retrospective observational study aimed to investigate the difference in 4-year outcomes of ranibizumab or aflibercept therapy for macular neovascularization (MNV) with high myopia between pathologic (PM) and non-PM. was conducted at Kyoto University Hospital included consecutive treatment-naïve eyes active myopic MNV, which a single intravitreal injection administered, followed by pro re nata (PRN) regimen 4 years. Based on META-PM classification, were assigned non-PM PM...
Optical coherence tomography angiography (OCTA) is a new technique for non-invasive imaging of blood vessels, allowing combined evaluation both deep and surface vessels. The purpose this study was to evaluate the post-trabeculectomy longitudinal changes in complete avascular area (CAA) filtering blebs using anterior segment (AS-) OCTA their association with surgical outcomes. This included 57 eyes 53 patients who had undergone trabeculectomy mitomycin C. AS-OCTA images bleb were acquired at...