A5033571681- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Visual Impairment Studies
- Neuroscience and Neural Engineering
- Ocular Infections and Treatments
- Photoreceptor and optogenetics research
- Vascular Malformations Diagnosis and Treatment
- Optical Coherence Tomography Applications
- Ocular Oncology and Treatments
- Tissue Engineering and Regenerative Medicine
- Systemic Lupus Erythematosus Research
- Proteoglycans and glycosaminoglycans research
- EEG and Brain-Computer Interfaces
- Heat transfer and supercritical fluids
- Ocular Disorders and Treatments
- Nuclear Materials and Properties
Osaka University
2016-2025
Chikamori Hospital
2018-2025
Kinan Hospital
2025
Osaka Rosai Hospital
2023-2025
Sakai Municipal Hospital
2020-2024
Osaka University of Pharmaceutical Sciences
2022-2024
Tokyo University of Agriculture and Technology
2023
Kajima Corporation (Japan)
2023
Ophthalmology Associates (United States)
2011-2022
Hiroshima Prefectural Hospital
2021
Ocular trauma or disease may lead to severe corneal opacification and, consequently, loss of vision as a result complete epithelial stem cells. Transplantation autologous stem-cell sources is an alternative allograft transplantation and does not require immunosuppression, but it possible in many cases which bilateral produces total deficiency both eyes. We studied the use oral mucosal cells source for reconstruction surface.We harvested 3-by-3-mm specimens tissue from four patients with...
Background: Despite extensive knowledge regarding the diagnosis and management of keratoconus ectatic corneal diseases, many controversies still exist. For that reason, there is a need for current guidelines these conditions. Purpose: This project aimed to reach consensus ophthalmology experts from around world focusing on their definition, concepts, clinical management, surgical treatments. Methods: The Delphi method was followed with 3 questionnaire rounds complemented face-to-face...
Background. Limbal stem-cell deficiency by ocular trauma or diseases causes corneal opacification and visual loss. Recent attempts have been made to fabricate epithelial graft constructs, but the technology is still evolving. We developed a novel cell-sheet manipulation using temperature-responsive culture surfaces generate functional, cultivated cell sheet grafts. Methods. Human rabbit limbal stem cells were cocultured with mitomycin C -treated 3T3 feeder layers on dishes at 37°C. Cell...
To investigate circadian changes in subfoveal choroidal thickness (SFCT) and the relation to systemic factors healthy subjects.Thirty-eight eyes of 19 volunteers were enrolled. SFCT was measured by using prototype high-penetration optical coherence tomography. Intraocular pressure (IOP), systolic blood (SBP), diastolic pressures (DBP), heart rate (HR) every 3 hours over a 24-hour period. Circadian mean arterial (MAP) ocular perfusion (MOPP) calculated. The difference between maximal minimal...
Two optical coherence tomography (OCT) modalities can visualize the choroid: high-penetration OCT (HP-OCT) using a long wavelength, and enhanced depth imaging technique Heidelberg (EDI-OCT). The purpose of this study was to compare investigate agreement among retinal/choroidal thickness parameters.Twenty-four eyes 12 healthy volunteers were examined simultaneously prototype swept-source HP-OCT EDI-OCT. Six independent examiners measured central thicknesses on horizontal B-scan images....
Immune attacks are key issues for cell transplantation. To assess the safety and immune reactions after iPS cells-derived retinal pigment epithelium (iPS-RPE) transplantation, we transplanted HLA homozygote iPS-RPE cells established at an bank in HLA-matched patients with exudative age-related macular degeneration. In addition, local steroids without immunosuppressive medications were administered. We monitored rejections by routine ocular examinations as well lymphocytes-graft reaction...
This study reports a new method for fabricating bioengineered human corneal endothelial cell sheets suitable ocular surgery and repair. We have initially cultured cells on type IV collagen-coated dishes and, after several passages, expanded were then seeded onto novel temperature-responsive culture dishes. Four weeks reaching confluence, these harvested as intact monolayer by simple temperature reduction without enzymatic treatment. Scanning electron microscopy indicated that primarily...
Many types of organ‐specific stem cells have been recently shown to exhibit a side population (SP) phenotype based on their ability efflux Hoechst 33342 dye. Because from corneal epithelium reside in the basal layer limbal epithelium, purpose this study was examine whether contains SP cells. The ATP‐binding cassette transporter Bcrp1/ABCG2 is reported contribute several diverse sources. Here we show data fluorescence‐activated cell sorting and real‐time quantitative RT‐PCR analysis showing...
To examine the safety and effectiveness of a retinal prosthesis that is implanted semichronically in two patients with advanced retinitis pigmentosa (RP).Two eyes RP had sclera pocket one eye. The visual acuity both before implantation was bare light perception. Phosphenes were elicited by suprachoroidal-transretinal stimulation (STS). internal devices STS under skin on temporal side head, 49 electrode-array scleral Biphasic electrical pulses (duration, 0.5 ms; frequency, 20 Hz) delivered...
During development, the retinal vasculature grows toward hypoxic areas in an organized fashion. By contrast, ischemic retinopathies, new blood vessels grow out of surfaces without ameliorating hypoxia. Restoration proper angiogenic directionality would be great benefit to reoxygenize retina and resolve disease pathogenesis. Here, we show that binding semaphorin 3E (Sema3E) ligand transmembrane PlexinD1 receptor initiates a signaling pathway normalizes both developing retinas retinopathy. In...
<h3>Aims</h3> The purpose of this study is to elucidate the clinical manifestations and current treatment status cytomegalovirus (CMV) endotheliitis via a large case series obtained from national survey conducted in Japan. <h3>Methods</h3> Japan Corneal Endotheliitis Study Group proposed diagnostic criteria for CMV based on viral examination by PCR aqueous humour, combination with manifestations. A was then retrospectively among 1160 members Cornea Society. reviewed patient profiles,...
Induced pluripotent stem (iPS) cells can be established from somatic cells. However, there is currently no strategy to generate corneal epithelial iPS In this study, we investigated whether could differentiated We tested 2 distinct sources: human adult dermal fibroblast (HDF)-derived (253G1) and limbal (HLEC)-derived (L1B41). first HLEC by introducing the Yamanaka 4 factors. Corneal were successfully induced stromal cell-derived inducing activity (SDIA) differentiation method, as Pax6+/K12+...