A5101976815- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Retinal Diseases and Treatments
- Ocular Infections and Treatments
- Systemic Lupus Erythematosus Research
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- T-cell and B-cell Immunology
- interferon and immune responses
- Autoimmune and Inflammatory Disorders Research
- Research on Leishmaniasis Studies
- Cerebral Venous Sinus Thrombosis
- Vasculitis and related conditions
- Sinusitis and nasal conditions
- Chemokine receptors and signaling
- Cytokine Signaling Pathways and Interactions
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal and Macular Surgery
Tokyo Medical and Dental University
2015-2024
The University of Tokyo
2018-2023
Visual Sciences (United States)
2020
Weatherford College
2019
National Eye Institute
2005-2008
National Institutes of Health
2004-2007
Laboratory of Molecular Genetics
2005
Nippon Dental University
1995
Hirosaki University
1990
Aims International criteria for the diagnosis of ocular sarcoidosis (OS) was established by first Workshop on Ocular Sarcoidosis (IWOS) and validations studies revealed certain limitations criteria. To overcome limitations, revised IWOS in an international meeting. This manuscript aimed at reporting Methods A consensus workshop carried out to discuss revise The held 27 April 2017, Nusa Dua, Bali, Indonesia. Prior workshop, a questionnaire proposing consisting one item differential diagnosis,...
<h3>Aims</h3> The purpose of this study is to elucidate the clinical manifestations and current treatment status cytomegalovirus (CMV) endotheliitis via a large case series obtained from national survey conducted in Japan. <h3>Methods</h3> Japan Corneal Endotheliitis Study Group proposed diagnostic criteria for CMV based on viral examination by PCR aqueous humour, combination with manifestations. A was then retrospectively among 1160 members Cornea Society. reviewed patient profiles,...
purpose. To determine whether patients with Vogt-Koyanagi-Harada (VKH) disease have immune responses specific to the melanocyte antigens tyrosinase and gp100. methods. T-cell clones (TCCs) were established from cells infiltrating aqueous humor peripheral blood mononuclear (PBMCs) of VKH. The target LDR4-transfected (HLA-DRB1*0405). TCCs cocultured LDR4 in presence (tyrosinase450-462: SYLQDSDPDSFQD), gp100 (gp10044-59: WNRQLYPEWTEAQRLD), or a control peptide. response was evaluated by...
To determine the cytokine expression profile at protein level in aqueous humor (AqH) and sera of patients with uveitis.Patients various clinical entities strictly diagnosed infectious or noninfectious uveitis were tested. AqH collected from uveitis. was also during surgery cataract, as control specimens. Interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-2, -4, -5, -10 measured nondiluted samples simultaneously, microparticle-based flow cytometric analysis.In...
Abstract T cells that encounter ocular pigment epithelium in vitro are inhibited from undergoing TCR-triggered activation, and instead acquire the capacity to suppress activation of bystander cells. Because retinal epithelial (RPE) cell by releasing soluble inhibitory factors, we studied whether factors also promote generation regulatory (Treg) We found RPE converted CD4+ into Treg producing secreting CTLA-2α, a cathepsin L (CathL) inhibitor. Mouse rCTLA-2α vitro, CTLA-2α small interfering...
Abstract Objective Primary vitreoretinal lymphoma (PVRL) is a rare type of wherein the lesions are limited to eyes. PVRL difficult diagnose because challenges related obtaining sufficient samples for biopsy. Moreover, has poor outcomes and often leads development central nervous system (CNS) during its course. Two studies recently reported that approximately 70%‐80% patients with have MYD88 L265P , which frequently mutated in primary CNS (PCNSL). PCNSL closely associated PVRL. The mutation...
To measure the bacterial genome in ocular fluids and to analyse clinical relevance of infectious endophthalmitis.Nineteen fluid samples (eight aqueous humour 11 vitreous samples) were collected from 19 patients with suspected endophthalmitis. Fifty uveitis also along 40 without inflammation used as controls. Bacterial ribosomal DNA (16S rDNA) was measured by a quantitative PCR assay.Bacterial 16S rDNA detected clinically endophthalmitis (18/19, 95%). With exception one case, high copy...
In Brief Purpose: To evaluate the fundus autofluorescence (FAF) patterns in eyes with primary intraocular lymphomas (PIOLs). Methods: A review of medical charts four consecutive patients (five eyes) PIOL who had been studied by FAF. camera was used to obtain FAF images. Optical coherence tomography also performed. Results: The ophthalmoscopically observed brown clumps on surface greasy yellowish masses beneath retinal pigmented epithelium a bright hyperfluorescence appearance This completely...
In Brief Purpose: To evaluate the subfoveal choroidal thickness (SCT) at convalescent stage of Vogt–Koyanagi–Harada disease and to investigate correlations among SCT, presence sunset glow fundus, size peripapillary atrophy (PPA). Methods: The medical records consecutive patients with without active intraocular inflammation were reviewed, one eye was randomly chosen for analyses. duration more than 3 years. Enhanced depth imaging optical coherence tomography performed measure SCT. area PPA...
In order to prevent central nervous system ( CNS ) involvement and improve the prognosis of primary intraocular lymphoma PIOL ), we prospectively evaluated efficacy combined therapy using intravitreal methotrexate MTX systemic high‐dose on treatment‐naïve . Patients with newly diagnosed whose was limited eyes were enrolled. The patients treated weekly until ocular lesions resolved, followed by five cycles (3.5 g/m 2 every other week. Ten enrolled in this study completed treatment. All...
Purpose: To establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip PCR) for concurrent detection of common ocular infectious disease pathogens. Methods: A PCR was established to detect 24 pathogens: herpes simplex virus (HSV) 1, HSV2, varicella-zoster (VZV), Epstein-Barr (EBV), cytomegalovirus (CMV), human (HHV) 6, HHV7, HHV8, T-cell lymphotropic (HTLV)-1, adenovirus, Mycobacterium tuberculosis, Treponema pallidum, Propionibacterium acnes (P. acnes),...
A novel multiplex polymerase chain reaction (PCR) test (Strip PCR) for 24 common ocular infectious disease pathogens was established. Solid-phase techniques provide stable, prompt, and accurate results while using less sample amount with lower cost than conventional quantitative real-time PCR (qPCR). Strip uveitis optimized evaluated intraocular samples.Evaluation of diagnostic testing.We examined 722 samples at 14 institutions. Genomic DNA from aqueous humor vitreous fluid analyzed by qPCR...
To establish expert recommendations for the management of ocular sarcoidosis (OS).A question-based survey on OS was circulated to international uveitis experts (members International Uveitis Study Group and Ocular Inflammation Society) electronically. Subsequently, a consensus workshop conducted at 7th Workshop Sarcoidosis (IWOS) in June 2019 Sapporo, Japan as part Global Workshops. Statements that were supported by two-thirds majority 10 panel members workshop, after discussion voting,...
Primary vitreoretinal lymphoma (PVRL) is a rare malignant subtype with an unfavorable prognosis due to frequent central nervous system (CNS) progression. Thus, identifying factors associated CNS progression essential for improving the of PVRL patients. Accordingly, we conducted comprehensive genetic analysis using archived vitreous humor samples 36 patients diagnosed and treated at our institution retrospectively examined relationship between alterations Whole-exome sequencing (n = 2)...
Pigment epithelium isolated from the eye possesses immunosuppressive properties such as regulatory T (Treg) cell induction; e.g., cultured retinal pigment (RPE) converts CD4(+) cells into Treg in vitro. RPE constitutively expresses a novel factor, CTLA-2alpha, which is cathepsin L (CathL) inhibitor, and this molecule acts via to induce cells. To clarify CTLA-2alpha's role response ocular inflammation, we used experimental autoimmune uveitis (EAU) animal model examine new property of RPE. In...