A5074139458- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- CNS Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Protease and Inhibitor Mechanisms
- Metastasis and carcinoma case studies
- PI3K/AKT/mTOR signaling in cancer
- Acute Lymphoblastic Leukemia research
- Erythrocyte Function and Pathophysiology
- Gastrointestinal Tumor Research and Treatment
- Retinoids in leukemia and cellular processes
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- T-cell and B-cell Immunology
- T-cell and Retrovirus Studies
- Pharmacological Effects of Natural Compounds
- Multiple Myeloma Research and Treatments
Hiroshima University Hospital
2023
Hiroshima University
2023
Tokyo Medical and Dental University
2013-2022
The University of Tokyo
1997-2022
Waseda University
2013-2021
Oita University Hospital
2018
Kyoto University
2018
Tokyo Medical and Dental University Hospital
2014
Yamaguchi University
1998-2014
Food Research Institute
2013
Abstract Objectives Patients with rheumatoid arthritis ( RA ) may develop lymphoproliferative disorders ‐ LPD ). Immunosuppressive states due to methotrexate MTX and Epstein–Barr virus EBV reactivation have been regarded as causes. Sometimes spontaneous regression occurs after withdrawal of . The objective this study was identify factors predictive relapse survival in patients , treated Methods We evaluated the clinicopathological features, clinical characteristics, treatment outcomes 102...
A role for tyrosine phosphorylation in the signal-transducing mechanisms of several hematopoietic growth factors has been hypothesized. To extend these observations, we have examined effects erythropoietin (Epo) on an Epo-responsive cell that was obtained by transfecting murine receptor (EpoR) into interleukin-3 (IL-3)-dependent line. By two-dimensional analysis phosphotyrosine-containing proteins isolated with a monoclonal antibody (1G2) against phosphotyrosine, Epo and IL-3 were found to...
The erythropoietin receptor (EpoR) belongs to the cytokine family, members of which lack a tyrosine kinase domain. Recent studies, however, have shown that cytoplasmic kinase, JAK2, interacts with domain EpoR and becomes activated upon binding Epo receptor. has also been stimulate activation Ras Raf-1. present studies were undertaken examine possible involvement Epo-induced phosphorylation in Ras/mitogen-activated protein (MAP kinase) pathway determine its significance on growth signaling...
The cytoplasmic domain of the erythropoietin receptor (EpoR) contains a region, proximal to transmembrane domain, that is essential for function and has homology with other members cytokine family. To explore functional significance this region identify critical residues, we introduced several amino acid substitutions examined their effects on erythropoietin-induced mitogenesis, tyrosine phosphorylation, expression immediate-early (c-fos, c-myc, egr-1) early (ornithine decarboxylase T-cell...
Regulation of oxidative stress and redox systems has important roles in carcinogenesis cancer progression, for this reason attracted much attention as a new area therapeutic targets. Glutathione peroxidase 4 (GPX4), an antioxidant enzyme, biological functions such signaling cell death by suppressing peroxidation membrane phospholipids. However, few studies exist on the expression clinical relevance GPX4 malignant lymphomas diffuse large B-cell lymphoma. In study, we assessed...
Adult T cell leukaemia/lymphoma (ATL) is a human leukaemia virus type-I (HTLV-I)-infected malignancy with poor prognosis. We herein developed novel therapeutic vaccine designed to augment an HTLV-I Tax-specific cytotoxic lymphocyte (CTL) response that has been implicated in anti-ATL effects, and conducted pilot study investigate its safety efficacy. Three previously treated ATL patients, classified as intermediate- high-risk, were subcutaneously administered the vaccine, consisting of...
Erythropoietin (Epo) regulates the proliferation and differentiation of erythroid precursors. The Epo receptor (EpoR) belongs to cytokine family lacks a tyrosine kinase domain. However, induces phosphorylation cellular substrates including EpoR. To explore functional significance phosphorylation, we examined possible interaction with 85-kDa regulatory subunit (p85) phosphatidylinositol (PI) 3-kinase. After stimulation, p85 was found associate tyrosine-phosphorylated 72-kDa form EpoR as well...
Systemic chronic active Epstein-Barr virus infection (sCAEBV) was defined as a T- or NK-cell neoplasm in the 2017 World Health Organization (WHO) classification. To clarify clinical features of sCAEBV under this classification and review effects chemotherapy, we performed nationwide survey Japan from 2016 through 2018 patients with newly diagnosed January 2003 March 2016. One hundred cases were evaluated. The aged 1 to 78 years (median, 21) included 53 males 47 females. Spontaneous...
Abstract Objective Primary vitreoretinal lymphoma (PVRL) is a rare type of wherein the lesions are limited to eyes. PVRL difficult diagnose because challenges related obtaining sufficient samples for biopsy. Moreover, has poor outcomes and often leads development central nervous system (CNS) during its course. Two studies recently reported that approximately 70%‐80% patients with have MYD88 L265P , which frequently mutated in primary CNS (PCNSL). PCNSL closely associated PVRL. The mutation...
// Ayako Nogami 1 , Gaku Oshikawa Keigo Okada Shusaku Fukutake Yoshihiro Umezawa Toshikage Nagao Tetsuya Kurosu Osamu Miura Department of Hematology, Graduate School Medical and Dental Sciences, Tokyo University, Tokyo, Japan Correspondence to: Miura, e-mail: miura.hema@tmd.ac.jp Keywords: AML, FLT3, PI3K, STAT5, MCL-1 Received: December 02, 2014 Accepted: February 07, 2015 Published: March 16, ABSTRACT FLT3-ITD FLT3-TKD are the most frequent tyrosine kinase mutations in acute myeloid...
Epstein-Barr virus (EBV) has been detected in several T- and NK-cell neoplasms such as extranodal NK/T-cell lymphoma nasal type, aggressive leukemia, EBV-positive peripheral T-cell lymphoma, systemic of childhood, chronic active EBV infection (CAEBV). However, how this contributes to lymphomagenesis T or NK cells remains largely unknown. Here, we examined NF-κB activation cell lines, SNT8, SNT15, SNT16, SNK6, primary clonally proliferating T/NK obtained from the blood patients with CAEBV....
In order to prevent central nervous system ( CNS ) involvement and improve the prognosis of primary intraocular lymphoma PIOL ), we prospectively evaluated efficacy combined therapy using intravitreal methotrexate MTX systemic high‐dose on treatment‐naïve . Patients with newly diagnosed whose was limited eyes were enrolled. The patients treated weekly until ocular lesions resolved, followed by five cycles (3.5 g/m 2 every other week. Ten enrolled in this study completed treatment. All...
FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML) associated with poor prognosis. We previously found that activates mTORC1/S6K/4EBP1 pathway cooperatively through STAT5/PIM and PI3K/AKT pathways to promote proliferation survival by enhancing eIF4F complex formation required for cap-dependent translation. Here, we show that, contrast BCR/ABL causing Ph-positive leukemias, distinctively serine/threonine kinases RSK1/2 activation of MEK/ERK PDK1 transduce...