A5069742724- Physics of Superconductivity and Magnetism
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- ZnO doping and properties
- Magnetic properties of thin films
- Laser Material Processing Techniques
- Nerve injury and regeneration
- Iron-based superconductors research
- Electronic and Structural Properties of Oxides
- Magnetic and transport properties of perovskites and related materials
- Semiconductor materials and devices
- Ion-surface interactions and analysis
- Spinal Cord Injury Research
- Acute Myeloid Leukemia Research
- Copper-based nanomaterials and applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Superconductivity in MgB2 and Alloys
- Acoustic Wave Resonator Technologies
- Copper Interconnects and Reliability
- Angiogenesis and VEGF in Cancer
- Neuroscience and Neuropharmacology Research
- Advanced Condensed Matter Physics
- Dental materials and restorations
- Neurobiology and Insect Physiology Research
MIND Research Institute
2019-2025
Cornell University
2019-2025
Burke Foundation
2021-2025
Burke Medical Research Institute
2019-2025
Okinawa Institute of Science and Technology Graduate University
2022-2025
Japanese Red Cross Kochi Hospital
2025
Kōchi University
2025
Weill Cornell Medicine
2019-2024
Cincinnati Children's Hospital Medical Center
2013-2023
Nagoya University
2010-2022
Striatal medium spiny neurons (MSN) are critically involved in motor control, and their degeneration is a principal component of Huntington's disease. We find that the transcription factor Ctip2 (also known as Bcl11b ) central to MSN differentiation striatal development. Within striatum, it expressed by all MSN, although excluded from essentially interneurons. In absence , do not fully differentiate, demonstrated dramatically reduced expression large number markers, including DARPP-32,...
Little is known about the organizational and functional connectivity of corticospinal (CS) circuits that are essential for voluntary movement. Here, we map between CS neurons in forelimb motor sensory cortices various spinal interneurons, demonstrating distinct CS-interneuron control specific aspects skilled movements. fibers originating mouse cortex directly synapse onto premotor including those expressing Chx10. Lesions or silencing Chx10+ interneurons produces deficits reaching. In...
During development, the retinal vasculature grows toward hypoxic areas in an organized fashion. By contrast, ischemic retinopathies, new blood vessels grow out of surfaces without ameliorating hypoxia. Restoration proper angiogenic directionality would be great benefit to reoxygenize retina and resolve disease pathogenesis. Here, we show that binding semaphorin 3E (Sema3E) ligand transmembrane PlexinD1 receptor initiates a signaling pathway normalizes both developing retinas retinopathy. In...
Blood vessel networks are typically formed by angiogenesis, a process in which new vessels form sprouting of endothelial cells from pre-existing vessels. This is initiated vascular growth factor (VEGF)-mediated tip cell selection and subsequent angiogenic sprouting. Surprisingly, we found that VEGF directly controls the expression Plexin-D1, receptor for traditional repulsive axon guidance cue, semaphorin 3E (Sema3E). Sema3E–Plexin-D1 signaling then negatively regulates activity VEGF-induced...
Commissural axon guidance requires complex modulations of growth cone sensitivity to midline-derived cues, but underlying mechanisms in vertebrates remain largely unknown. By using combinations ex vivo and approaches, we uncovered a molecular pathway controlling the gain response midline repellent, Semaphorin3B (Sema3B). First, provide evidence that Semaphorin3B/Plexin-A1 signaling participates commissural projections at vertebrate ventral midline. Second, show that, precrossing stage,...
The disappearance of fine motor control Manual skills are much better developed in primates than rodents. This difference is part due to species-specific differences the motoneurons by brain. Gu et al. used a range approaches evaluate potential corticospinal tract projections neonatal mice. These exist immediately after birth but disappear within first 2 postnatal weeks owing actions plexin A, member semaphorin receptor family. Targeted deletion receptors mutant mice prevented elimination...
Six cases were described in which an initial clinical diagnosis of "rhinitis gangrenosa progressiva" or lethal midline granuloma was made. The histological examinations their surgical and autopsy specimens proved that nasologic diseases could all be identified as malignant lymphoma arising from the nasal cavity, showing general histologic characteristics reported for T-cell lymphomata derived peripheral T-cells. This observation then confirmed by immunofluorescence studies using various...
The organization of neural progenitors in the developing mammalian neuroepithelium is marked by cadherin-based adherens junctions. Whereas RhoA, a founding member small Rho GTPase family, has been shown to play important roles epithelial junctions, its physiological development remain uncertain due lack specific loss-of-function studies. Here, we show that RhoA protein accumulates at junctions mouse brain and colocalizes cadherin–catenin complex. Conditional deletion midbrain forebrain using...
Neural circuit formation requires the coordination of many complex developmental processes. First, neurons project axons over long distances to find their final targets and then establish appropriate connectivity essential for neuronal circuitry. Growth cones, leading edges axons, navigate by interacting with a variety attractive repulsive axon guidance cues along trajectories at target regions. In addition polarization, migration dendrite development must be precisely regulated during...
Hippocampal mossy fibers project preferentially to the proximal-most lamina of suprapyramidal region CA3, stratum lucidum, and parts infrapyrmidal CA3c. Molecular mechanisms that govern lamina-restricted projection fibers, however, have not been fully understood. We previously studied functions neural repellent Semaphorin-6A (Sema6A), a class 6 transmembrane semaphorin, its receptors, plexin-A2 (PlxnA2) PlxnA4, in fiber proposed PlxnA4-expressing are principally prevented from entering...
In mammalian spinal cord, group Ia proprioceptive afferents form selective monosynaptic connections with a select of motor pool targets. The extent to which sensory recognition neurons contributes the selectivity sensory-motor remains unclear. We show here that express PlexinD1 avoid forming in Sema3E+ pools yet are able direct Sema3Eoff pools. Anatomical and electrophysiological analysis mice Sema3E-PlexinD1 signaling has been deregulated or inactivated genetically reveals repellent...