A5010057808- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Pancreatic function and diabetes
- Renal function and acid-base balance
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Diabetes and associated disorders
- Coffee research and impacts
- Nutrition, Health and Food Behavior
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Eating Disorders and Behaviors
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Regulation of Appetite and Obesity
- Vitamin K Research Studies
- Bone and Dental Protein Studies
- Blood properties and coagulation
- Alcoholism and Thiamine Deficiency
Tokushima University
2017-2025
Institute of Biomedical Science
2017
Hyogo Medical University
2013
Advanced glycation end-products (AGEs), which are a major cause of diabetic vascular complications, accumulate in various tissues under chronic hyperglycemic conditions, as well with aging patients diabetes. The loss muscle mass and strength, so-called sarcopenia dynapenia, has recently been recognized complication. However, the influence accumulated AGEs on strength remains unclear. present study aimed to evaluate association dynapenia type 2 diabetes.We recruited 166 diabetes aged ≥30...
Background Impacts of chronic systemic inflammation and body size their interaction effect on insulin resistance in Asian populations, whom obesity is less common, are not fully understood. This study evaluated combined relationships with a Japanese cohort. Methods We analyzed cross-sectional data from 1,074 eligible subjects (536 men 538 women) aged 35–69 years who participated the baseline survey cohort Tokushima Prefecture, Japan. Systemic level was assessed by serum high-sensitivity...
Cigarette smoking is one of the most important risk factors for lung cancer. Genetic studies have shown that behavior-related genetic variants are directly associated with cancer, independent behavior, mainly in European populations. A recent genome-wide association study Japan identified five loci number cigarettes smoked per day. This aimed to evaluate whether these cancer or indirectly through changing behavior. Here, we conducted a case-control (1427 cases and 5595 controls) prospective...
<p>Supplementary Table S1-S14</p>
<p>Supplementary File (List of the contributors to J-MICC Study)</p>
Coffee may contribute to the prevention of metabolic abnormalities in both obese and normal weight Japanese adults. Although evidence suggests a relationship between coffee serum adiponectin, stratified analyses according obesity status have not yet been reported. This cross-sectional study examined intake high molecular (HMW)-adiponectin, which is most active form status. The baseline data 606 participants (aged 35-69 years) living Tokushima prefecture Japan Multi-Institutional...
Purpose The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. purpose this study was to examine associations MetS metabolically unhealthy obesity (MUHO) with mortality in Japanese population. Methods We used data Japan Multi-Institutional Collaborative Cohort Study. population consisted 28,554 eligible subjects (14,103 men 14,451 women) aged 35–69 years. diagnosed based on criteria National Cholesterol Education Program Adult...
Background: Nutrients have been proposed to be related metabolic syndrome (MetS). The aims of this study were identify dietary patterns that correlated with several nutrients using reduced rank regression (RRR) and examine the association between extracted prevalence MetS in a Japanese population.
The objective of the present study was to investigate correlations between serum undercarboxylated osteocalcin (ucOC) or (OC) concentrations and %body fat, adiponectin free-testosterone concentration, muscle strength dose exogenous insulin in patients with type 1 diabetes. We recruited 73 Japanese young adult childhood-onset All participants were receiving replacement therapy. logarithmic ucOC OC each parameter examined. Serum inversely correlated fat (r = -0.319, P 0.007; r -0.321, 0.006,...
Abstract To investigate unknown patterns associated with type 2 diabetes in the Japanese population, we first used an alternating decision tree (ADTree) algorithm, a powerful classification algorithm from data mining, for 1,102 subjects aged 35–69 years. On basis of investigated patterns, then evaluated associations serum high-sensitivity C-reactive protein (hs-CRP) as biomarker systemic inflammation and family history (negative, positive or unknown) prevalence because their detailed have...
We examined the association between dairy intake and all-cause, cancer, cardiovascular disease mortality in a cohort of general population followed up for 12 years across Japan.
The beneficial effects of dietary calcium intake on high-sensitivity C-reactive protein levels, a risk factor cardiovascular disease, have not been fully elucidated. This study investigated the associations between and serum levels in general Japanese population. We analyzed data 2,019 subjects (1,194 men 825 women) aged 35 to 69 years cross-sectional Japan Multi-Institutional Collaborative Cohort Study. Nutrients including were estimated using validated food-frequency questionnaire....
Abstract Glomerular filtration rate (GFR) and urinary albumin excretion (UAER) are used to diagnose classify the severity of chronic kidney disease. Total adiponectin (T-AN) high molecular weight (H-AN) assays were developed using fully automated immunoassay system, HI-1000 their significance over conventional biomarkers investigated. The T-AN H-AN had reproducibility, good linearity, sufficient sensitivity detect trace amounts in urine. Urine samples after gel analyzed for presence...
To investigate the basal insulin requirement in patients with type 1 diabetes who are on multiple daily injections (MDI) and to assess patient characteristics that affect percent of total dose (%TBD/TDD).
<h3>Background</h3> Abatacept (CTLA4-Ig) is a new therapeutic agent used for rheumatoid arthritis (RA). Recently, it reported that CTLA-4 directly inhibits osteoclast formation. On the other hand, Osteopontin (OPN) produced by activated T lymphocytes and has been recognized as one of key molecules osteoclastic bone-resorption in RA. However, effect abatacept on bone homeostasis OPN production RA poorly understood. In this study, we investigated effects biochemical markers bone, serum soluble...
We previously developed two immune complex transfer enzyme immunoassays (ICT-EIA) to measure total adiponectin (T-AN) and high molecular weight (H-AN) in urine have verified their usefulness as biomarkers for diabetic kidney disease. In this study, we T-AN H-AN assays using the sandwich EIA (Sand-EIA). The reactivities of Sand-EIAs were compared with ICT-EIAs by measuring size exclusion chromatography (SEC) fractions standard. As a result, showed higher macromolecular specificity. then...
Abstract The present study investigated the relationship between metabolic phenotypes and risk of cancer in a Japanese population using criteria based on an examination those questionnaires. We used data from 25,357 subjects for examination-based analyses 53,042 questionnaire-based Japan Multi-institutional Collaborative Cohort study. Metabolic were defined by classifying according to their body mass index (BMI; obesity: BMI ≥25 kg/m2; normal weight: &lt;25 kg/m2) number abnormalities....
<title>Abstract</title> <bold>Purpose:</bold>The impact of diet on the body acid-base balance may be related to risk various chronic diseases. Despite emerging evidence relationships between dietary acid load and all-cause cause-specific mortalities, further information is needed. This prospective cohort study examined mortalities in a large Japanese population. <bold>Methods: </bold>The data 74,360 subjects (aged 35-69 years baseline survey) Japan Multi-Institutional Collaborative Cohort...
<p>Flowcharts of the selection study participants. <b>A,</b> Study participants for analyses examination-based metabolic phenotypes. <b>B,</b> questionnaire-based phenotypes.</p>
<div>Abstract<p>The present study investigated the relationship between metabolic phenotypes and risk of cancer in a Japanese population using criteria based on an examination those questionnaires. We used data from 25,357 subjects for examination-based analyses 53,042 questionnaire-based Japan Multi-institutional Collaborative Cohort study. Metabolic were defined by classifying according to their body mass index (BMI; obesity: BMI ≥25 kg/m<sup>2</sup>; normal weight:...
<p>Background characteristics of participants according to obesity classification</p>