A5057968270- Alcohol Consumption and Health Effects
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Genomic variations and chromosomal abnormalities
- Genetic Associations and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Nutrition, Genetics, and Disease
- Gastric Cancer Management and Outcomes
- Viral-associated cancers and disorders
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Esophagitis
- Genetic and phenotypic traits in livestock
- Menopause: Health Impacts and Treatments
- T-cell and Retrovirus Studies
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
Aichi Cancer Center
2006-2025
Nagoya University
2020-2024
Organ Technologies (Japan)
1999
Helicobacter pylori infection is a well-known risk factor for gastric cancer. However, the contribution of germline pathogenic variants in cancer-predisposing genes and their effect, when combined with H. infection, on cancer has not been widely evaluated.We evaluated association between 27 sample 10,426 patients 38,153 controls from BioBank Japan. We also assessed effect status calculated cumulative 1433 5997 Hospital-based Epidemiologic Research Program at Aichi Cancer Center...
Malfunctions in the formaldehyde clearance processes induce DNA damage and overload repair system cause AMeD syndrome.
The TEL (ETV6)–AML1 (RUNX1) chimeric gene fusion is the most common genetic abnormality in childhood acute lymphoblastic leukemias. Evidence suggests that this constitutes an initiating mutation necessary but insufficient for development of leukemia. In a search additional events could be linked to leukemia, we applied genome‐wide array‐comparative genomic hybridization technique 24 TEL–AML1 leukemia samples and two cell lines. It was found at least chromosomal imbalances were involved all...
Reproductive factors, such as age at menarche, are known to be associated with disease risk, but data on trends in these factors Japan limited. In this study, we investigated secular reproductive and explored their potential association socioeconomic historical events.
Amplification of 2p has been observed as a recurrent alteration in diffuse large B‐cell lymphoma (DLBCL). Whereas two candidate oncogenes, REL and BCL11A , have investigated targets for amplification, the question remains to whether true target gene amplicon is or both. We previously identified frequent genomic gains chromosomal 25 out 99 DLBCL cases by means genome‐wide array comparative hybridization (CGH). All these included copy number gain at 2p15–16. In study presented here, were...
A genetic variant on aldehyde dehydrogenase 2 (ALDH2 rs671, Glu504Lys) contributes to carcinogenesis after alcohol consumption. Somewhat conversely, the ALDH2 Lys allele also confers a protective effect against alcohol-induced by decreasing consumption due acetaldehyde-related adverse effects. Here, we applied mediation analysis five case-control studies for head and neck, esophageal, stomach, small intestine, colorectal cancers, with 4,099 cases 6,065 controls, explored potentially...
Cigarette smoking is one of the most important risk factors for lung cancer. Genetic studies have shown that behavior-related genetic variants are directly associated with cancer, independent behavior, mainly in European populations. A recent genome-wide association study Japan identified five loci number cigarettes smoked per day. This aimed to evaluate whether these cancer or indirectly through changing behavior. Here, we conducted a case-control (1427 cases and 5595 controls) prospective...
Abstract Purpose: Increases in gene dosage through DNA amplification represents a common feature of many tumors and can result the up-regulation tumor-promoting genes. Our recent genome-wide, array-based comparative genomic hybridization analysis 66 cases diffuse large B-cell lymphoma found that gain 6p21 was observed as 17 cases, including 14 with low-level copy number three high-level gains (amplifications). Experimental Design Results: To identify target gene(s) for amplification, we...
Mesotheliomas are frequently characterized by disruption of Hippo pathway due to deletion and/or mutation in genes, such as neurofibromin 2 ( NF2 ). attenuates yes-associated protein (YAP) phosphorylation allowing YAP translocate the nucleus and regulate gene expression. The role disrupted maintenance established mesotheliomas has been extensively investigated using cell lines; however, its involvement development human mesothelioma not explored much. Here, we employed immortalized...
Helicobacter pylori infection is a significant risk factor for gastric cancer. The acquired mainly in early childhood and influenced by environmental factors, including socioeconomic status sibling number. However, the impact of number on has not been well studied Japan. We conducted cross-sectional study to evaluate status, represented education level, prevalence among 3,423 non-cancer subjects who visited Aichi Cancer Center between 2005 2013. calculated odds ratios (ORs) 95% confidence...
Although socioeconomic status (SES) has been associated with cancer risk, little research on this association done in Japan. To evaluate the between SES and digestive tract we conducted a case-control study for head neck, esophageal, stomach, colorectal cancers 3188 cases same number of age- sex-matched controls within framework Hospital-based Epidemiological Research Program at Aichi Cancer Center III (HERPACC III). We employed education level areal deprivation index (ADI) as indicators....
The associations between blood lipids, including total cholesterol (TC), high-density lipoprotein (HDL-C), triglycerides, and low-density (LDL-C), colorectal cancer risk are controversial. We evaluated potential causal relationships lipids risk. Using the baseline data from Japanese Consortium of Genetic Epidemiology studies, we estimated single-nucleotide polymorphism (SNP)-exposure (n = 34,546 for TC, n 50,290 HDL-C, 51,307 30,305 LDL-C). also SNP-outcome in another dataset 7,936 cases...
Background: Obesity is a reported risk factor for various health problems. Genome-wide association studies (GWASs) have identified numerous independent loci associated with body mass index (BMI). However, most of these been focused on Europeans, and little evidence available the genetic effects across life course other ethnicities.
As part of our efforts to develop practical intervention applications for cancer prevention, we investigated a risk prediction model gastric based on genetic, biological, and lifestyle-related factors.We conducted two independent age- sex-matched case-control studies, the first derivation (696 cases 1392 controls) second (795 795) external validation. Using study data, developed by fitting conditional logistic regression using predictors age, ABCD classification defined H. pylori infection...
Adult T‐cell leukemia/lymphoma ( ATL ) develops in human leukemia virus type 1 HTLV ‐1) carriers. Although the ‐1‐encoded HBZ gene is critically involved, alone insufficient and additional, cooperative “hits” are required for development of . Candidate hits being defined, but methods to rapidly explore their roles collaboration with lacking. Here, we present a new mouse model acute that can be generated by transplanting vitro ‐induced T cells have been retrovirally transduced two genes, BCL...
A functional variant on ALDH2 rs671 (G>A) confers a protective effect against alcohol-induced carcinogenesis through an indirect pathway mediated by decreased alcohol consumption. Conversely, this also contributes to the accumulation of carcinogenic agents, resulting in direct effect. This study aimed separately quantify these two opposing effects allele pancreatic cancer risk and explore impact consumption carcinogenesis. We included 426 cases 1456 age- sex-matched controls. Odds ratio (OR)...