A5006235348- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Genetic factors in colorectal cancer
- Lipid metabolism and disorders
Aichi Cancer Center
2022-2023
The associations between blood lipids, including total cholesterol (TC), high-density lipoprotein (HDL-C), triglycerides, and low-density (LDL-C), colorectal cancer risk are controversial. We evaluated potential causal relationships lipids risk. Using the baseline data from Japanese Consortium of Genetic Epidemiology studies, we estimated single-nucleotide polymorphism (SNP)-exposure (n = 34,546 for TC, n 50,290 HDL-C, 51,307 30,305 LDL-C). also SNP-outcome in another dataset 7,936 cases...
Abstract Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation analysis was performed determine between genetic variants associated with elevated fasting glucose, haemoglobin A1c (HbA1c), C-peptide cancer risk. In single nucleotide polymorphism (SNP)-exposure analysis, we meta-analysed study-level genome-wide...