A5041145642- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Cancer Research and Treatments
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Colorectal Cancer Screening and Detection
- Mechanisms of cancer metastasis
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Pediatric Hepatobiliary Diseases and Treatments
- RNA modifications and cancer
- Alcohol Consumption and Health Effects
- Enzyme Production and Characterization
Aichi Cancer Center
2016-2025
Osaka Metropolitan University
2022-2024
Osaka City University
2023-2024
Osaka University
2002-2024
San-Ei Gen F.F.I (Japan)
2024
Protein Research Foundation
2024
Tenshi Hospital
2023
Tokyo Metropolitan University
2022
Yokohama City University
2021
Hokkaido University
2020
Abstract Background Although some retrospective studies have suggested the value of adjuvant therapy, no recommended standard exists in bile duct cancer. The aim this study was to test hypothesis that gemcitabine chemotherapy would improve survival probability resected Methods This a randomized phase III trial. Patients with cancer were assigned randomly and observation groups, which balanced respect lymph node status, residual tumour status location. Gemcitabine given intravenously at dose...
Pancreatic ductal adenocarcinoma (PDAC) may derive from an intraductal papillary mucinous neoplasm (IPMN) of the pancreas or develop in pancreatic duct apart IPMN. The purpose this study was to define clinicopathological features these 2 entities and compare them with those ordinary PDAC.Of 765 patients who had surgical resection for IPMN, 122 were diagnosed as having PDAC derived IPMN 31 concomitant In addition, 7605 registered Japan Pancreas Society cancer registry compared above...
Clinical Practice Guidelines for Pancreatic Cancer was first published in 2006 by the Japan Pancreas Society, and revised 2009, 2013, 2016, 2019. In July 2022, newly Japanese.For this revision, we developed an entirely new guideline according to Minds Manual Guideline Development 2020, which includes concepts of GRADE-Grading Recommendations Assessment, Development, Evaluation, enable a better understanding current guidelines. Patients public were actively involved both development...
<b>Background and study aim:</b> Malignancy in pancreatic neuroendocrine tumors (PNETs) is graded by assessing the resected specimens according to World Health Organization (WHO) 2010 criteria. The feasibility of such grading using endoscopic ultrasound-guided fine-needle aspiration (EUS–FNA) remains unclear. aim this was ascertain optimal method measuring Ki-67 index EUS–FNA specimens, as criterion standard. <b>Patients methods</b>: A total 58 consecutive patients diagnosed with PNETs...
OBJECTIVES: Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) has recently been reported as an alternative to percutaneous transhepatic biliary drainage (PTBD) in cases of obstruction, when endoscopic (EBD) is unsuccessful. However, prospective studies EUS-CDS have not yet performed. We conducted a study evaluate the safety, feasibility, and efficacy patients with malignant lower tract obstruction. METHODS: A confirm safety was carried out 6 patients, followed by trial...
Five patients with obstructive jaundice caused by malignant periampullary biliary stenosis underwent EUS-guided choledochoduodenostomy (EUS-CDS) from the first portion of duodenum using a convex echoendoscope and needle knife. All steps procedure including passage dilatation plastic stent placement were performed through accessory channel over guide wire. Stent insertion was technically successful in all five patients. The also clinically effective relieving cases. One patient developed...
Abstract Background The aim of the study was to investigate prognostic impact lymph node metastasis in cholangiocarcinoma using three different classifications. Methods Patients who underwent pancreaticoduodenectomy for distal 24 hospitals Japan between 2001 and 2010 were included. Survival calculated by means Kaplan–Meier method differences subgroups assessed with log rank test. Cox proportional hazards model used identify independent predictors survival. χ2 scores determine cut-off value...
A prospective clinical study was conducted to evaluate the safety, feasibility, and efficacy of endoscopic ultrasound (EUS)-guided choledochoduodenostomy (CDS) with direct metallic stent placement using a prototype forward-viewing echoendoscope. The indication for EUS – CDS in this lower biliary obstruction only, not failed drainage, because aim first-line drainage therapy. technical functional success rates were 94 % (17 /18) (16 /17), respectively. Early complications (focal peritonitis)...
The present study was a retrospective investigation of predictors malignancy in intraductal papillary mucinous neoplasm (IPMN) the pancreas.The subjects were 310 patients who underwent pancreatic resection at 3 high-volume centers. Preoperative laboratory and imaging findings analyzed logistic regression analyses. Endoscopic ultrasonography measurements essential for size mural nodules, central review conducted pathological diagnosis.Pathological diagnosis benign IPMN 150 cases malignant 160...
Few studies have been conducted on patterns of recurrence after resection for distal cholangiocarcinoma (DCC). The aim this study was to investigate the incidence and pattern DCC, evaluate prognostic factors time recurrence-free survival (RFS).Patients who underwent pancreatoduodenectomy with curative intent DCC between 2001 2010 at one 30 hospitals in Japan were reviewed retrospectively, special attention patterns. Cox proportional hazards model used multivariable analysis.In interval, 389...
Free cancer cells in the abdominal cavity exfoliated from a tumor are considered to be responsible for peritoneal dissemination, most frequent pattern of failure gastric carcinoma patients treated with curative surgery.A prospective survival analysis was performed 91 by potentially resection. Cytology all patients. The method Kaplan and Meier used construct curves diagnosis dissemination death as end points. Multivariate Cox's proportional hazards model identify independent prognostic...
PURPOSE: Previous reports have suggested that mucinous colorectal adenocarcinomas are more advanced at diagnosis and a poorer prognosis than nonmucinous adenocarcinomas. The purpose of this study was to clarify whether the mucin-producing histologic type carcinoma is associated with worse nonmucinous, differentiated adenocarcinoma for patients who undergo curative surgery. METHODS: Using database 2,678 surgical cancers operated on Aichi Cancer Center between 1965 1994, we investigated 97...
Hepatocellular carcinoma (HCC) most commonly arises from chronic inflammation due to viral infection, as a result of genetic and epigenetic abnormalities. A global picture changes in HCC is lacking. We used methylated CpG island amplification microarrays (MCAMs) study 6458 islands adjacent preneoplastic tissues [chronic hepatitis (CH) or liver cirrhosis (LC)] comparison with normal where neither infection nor has existed. MCAM identified 719 (11%) prominent genes hypermethylation HCCs. HCCs...
Corrected by: Development of pancreatic cancers during long-term follow-up side-branch intraductal papillary mucinous neoplasmsEndoscopy 2011; 43(01): 79-79DOI: 10.1055/s-0030-1256071
Abstract It is believed that the plastids in green plants lost peptidoglycan (i.e., a bacterial cell wall-containing d-amino acids) during their evolution from an endosymbiotic cyanobacterium. Although wall-like structures could not be detected of plants, moss Physcomitrella patens has genes required to generate (Mur genes), and knocking out these causes defects chloroplast division. Here, we generated P. knockout lines (∆Pp-ddl) for homolog peptidoglycan-synthetic gene encoding d-Ala:d-Ala...