A5065889075- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Alcohol Consumption and Health Effects
- BRCA gene mutations in cancer
- Sleep and Work-Related Fatigue
- Helicobacter pylori-related gastroenterology studies
- Sleep and related disorders
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Circadian rhythm and melatonin
- Pancreatic and Hepatic Oncology Research
- Diet, Metabolism, and Disease
- Acute Lymphoblastic Leukemia research
- Nutrition, Genetics, and Disease
- Childhood Cancer Survivors' Quality of Life
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Sleep and Wakefulness Research
- Colorectal Cancer Surgical Treatments
- Breast Cancer Treatment Studies
- Cleft Lip and Palate Research
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Multiple and Secondary Primary Cancers
National Center for Global Health and Medicine
2025
Aichi Cancer Center
2021-2024
RIKEN Center for Integrative Medical Sciences
2023
Kouseiren Takaoka Hospital
2023
Osaka University
2017-2020
Osaka Health Science University
2020
Osaka International Cancer Institute
2020
University of Miyazaki
2010-2015
University of Occupational and Environmental Health Japan
2005
Helicobacter pylori infection is a well-known risk factor for gastric cancer. However, the contribution of germline pathogenic variants in cancer-predisposing genes and their effect, when combined with H. infection, on cancer has not been widely evaluated.We evaluated association between 27 sample 10,426 patients 38,153 controls from BioBank Japan. We also assessed effect status calculated cumulative 1433 5997 Hospital-based Epidemiologic Research Program at Aichi Cancer Center...
The clinical importance of genetic testing BRCA1 and BRCA2 in breast, ovarian, prostate, pancreatic cancers is widely recognized. However, there insufficient evidence to include other cancer types that are potentially associated with management guidelines.To evaluate the association pathogenic variants additional their characteristics 100 914 individuals across 14 types.This case-control analysis identify included DNA samples information from 63 828 patients common 37 086 controls were...
Reproductive factors, such as age at menarche, are known to be associated with disease risk, but data on trends in these factors Japan limited. In this study, we investigated secular reproductive and explored their potential association socioeconomic historical events.
ABSTRACT While male breast cancer (MBC) remains a rare and understudied disease, comparatively little is known about its prognosis in contrast to female (FBC). There paucity of large population‐based studies comparing the MBC patients FBC Japan. This study analyzed 181,540 cases, 1058 (0.6%) males 180,482 (99.4%) females, from 12 prefectures Japan diagnosed between 1993 2011. Five‐ ten‐year net survival (NS) were estimated stratified by sex, period, age, stage, histological groups. Excess...
Abstract The relationship between hospital volume and patient outcome is globally known; thus, widely used as a quality indicator. In Japan, however, recent studies on this topic are scarce. present study examined whether surgery associated with postoperative 5‐year survival among cancer patients. Using the Osaka Cancer Registry, we identified sample of 86 145 patients who were diagnosed at any five different sites (stomach, colorectum, lung, breast uterus) underwent surgeries 2007 2011 in...
Long-term sickness absence (LTSA) is an important public health challenge, yet limited data exist on its incidence in Japan. We aimed to describe the of all-cause and cause-specific LTSA by sex age, using 10-year from a large Japanese working population, focusing differences. The study participants were employees 16 worksites Japan Epidemiology Collaboration Occupational Health Study between April 2012 March 2022. LTSA, defined as work lasting 30 days or more, was recorded at each worksite....
To estimate cumulative incidence and mortality risk for gastric cancer by category.Risk was classified into four types according to the presence/absence of Helicobacter pylori infection chronic atrophic gastritis: in order lowest highest risk, Group A: H. pylori(-) gastritis(-); B: pylori(+) C:H. gastritis(+); and, D: gastritis(+). We used vital statistics crude all-cause rates 2011 data from population-based registries (the Monitoring Cancer Incidence Japan) 2011. For relative prevalence,...
The aim of this study was to examine the relationship between shift-work disorder (SWD) and environmental somatic factors related falling asleep among rapidly rotating shift workers in a manufacturing industry.A total 556 male were recruited complete self-administered questionnaire regarding age, work experience, lifestyle, family structure; Epworth sleepiness scale (ESS); Pittsburgh sleep quality index (PSQI); Horne Ostberg questionnaire, for asleep. We classified according having SWD or...
Idiopathic hypersomnia (IH) is a rare, heterogeneous sleep disorder characterized by excessive daytime sleepiness. In contrast to narcolepsy type 1, which well-defined of central disorders hypersomnolence, the etiology IH poorly understood. No susceptibility loci associated with have been clearly identified, despite tendency for familial aggregation IH. We performed variation screening prepro-orexin/hypocretin and orexin receptors genes an association study in Japanese population,...
Advances in diagnostic techniques and treatment modalities have impacted head neck cancer (HNC) prognosis, but their effects on subsite-specific prognosis remain unclear. This study aimed to assess trends mid- long-term survival for HNC patients diagnosed from 1993 2011 using data population-based registries Japan. We estimated the net (NS) by subsite 13 prefectural Changes over time were assessed multivariate excess hazard model of mortality. In total, 68,312 included this analysis....
Recently, corporate social responsibility (CSR) is becoming widely recognized as an issue for Japanese companies. Corporate employees considered important by various stakeholders, and occupational safety health regarded one of these responsibilities. The present authors examined this from the viewpoint management analysis statements found in CSR-related reports. For companies listed on First Section Tokyo Stock Exchange (TSE), we searched reports, titles contents, based two established...
Workers with shift work schedules often experience disorder (SWD). However, all workers do not necessarily develop SWD. The aim of this cross-sectional study was to investigate the association between susceptibility SWD and clock gene polymorphisms. A total 257 male from a semiconductor factory were recruited in study. Participants completed questions about age, body mass index (BMI), history, lifestyle, living conditions, Epworth Sleepiness Scale (ESS) score, Pittsburgh Sleep Quality Index...
The impact of hospital surgical volume on long-term mortality has not been well assessed in Japan, especially for esophageal, biliary tract, and pancreatic cancer, although these three cancers need a high level medical-technical skill. purpose this study was to examine associations between 3-year severe-prognosis cancer patients.
Objective: In 2013, 15 childhood cancer hub hospitals in Japan were designated to provide quality medical treatment and care. The present study assessed hospital accessibility by investigating travel times distances from patient residences. Methods: A total of 37,309 residence/hospital pairs generated using the addresses that 2019 local government offices 2014. Using Google Directions Application Programming Interface (API), calculated on assumption each would arrive driving 10 am Wednesday,...
As part of our efforts to develop practical intervention applications for cancer prevention, we investigated a risk prediction model gastric based on genetic, biological, and lifestyle-related factors.We conducted two independent age- sex-matched case-control studies, the first derivation (696 cases 1392 controls) second (795 795) external validation. Using study data, developed by fitting conditional logistic regression using predictors age, ABCD classification defined H. pylori infection...
A functional variant on ALDH2 rs671 (G>A) confers a protective effect against alcohol-induced carcinogenesis through an indirect pathway mediated by decreased alcohol consumption. Conversely, this also contributes to the accumulation of carcinogenic agents, resulting in direct effect. This study aimed separately quantify these two opposing effects allele pancreatic cancer risk and explore impact consumption carcinogenesis. We included 426 cases 1456 age- sex-matched controls. Odds ratio (OR)...
Personalized approaches to prevention based on genetic risk models have been anticipated, and many for the prediction of individual breast cancer developed. However, few studies evaluated personalized using both environmental factors. We developed a model factors 1319 cases 2094 controls from three case–control in Japan. Risk groups were defined number alleles 14 susceptibility loci, namely low (0–10 alleles), moderate (11–16) high (17+). Environmental collected self-administered...
The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) gefitinib and erlotinib were approved for metastatic or relapsed non-small cell lung cancer (NSCLC) in Japan 2002 2007, respectively. EGFR mutation testing was also 2007. Although clinical trials showed efficacy NSCLC patients harboring activating mutations, these effects have rarely been reported real-world practice. We evaluated changes survival following introduction of agents by extracting diagnosed with from...
Ingested alcohol is predominantly oxidized to acetaldehyde by dehydrogenase 1B (ADH1B), and further acetate mainly aldehyde 2 (ALDH2). Although consumption a convincing risk factor for oesophageal cancer, the role of ADH1B rs1229984 (His48Arg), single-nucleotide polymorphism associated with slow metabolism, in cancer development unclear. Because this both increased drinking intensity, its association might operate either through direct pathway independently via an indirect mediated or...
Approximately 5%-10% of breast cancers are hereditary, caused by germline pathogenic variants (GPVs) in cancer predisposition genes. To date, most studies the prevalence GPVs and risk for each gene based on cases noncancer controls have been conducted Europe United States, little information from Japanese populations is available. Furthermore, no considered confounding established environmental factors single-nucleotide polymorphisms (SNPs) identified genome-wide association (GWAS) together...
Falling asleep at the wheel is attributed to sleepiness, and obstructive sleep apnea a significant cause of sleepiness that increases risk motor vehicle collisions due falling wheel. Although continuous positive airway pressure therapy for reduces collisions, similar evidence alternatives such as oral appliance lacking. We discuss two truck microsleep confirmed with dashcam video footage commercial drivers apnea. Our results highlight current situation where there insufficient prevention...