Shogyoku Bun
A5065692454- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Digital Mental Health Interventions
- Mental Health Research Topics
- Treatment of Major Depression
- Long-Term Effects of COVID-19
- Ginkgo biloba and Cashew Applications
- COVID-19 and Mental Health
- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Telemedicine and Telehealth Implementation
- Electroconvulsive Therapy Studies
- Electrolyte and hormonal disorders
- Aging and Gerontology Research
- Thermal Regulation in Medicine
- Cancer-related cognitive impairment studies
- COVID-19 Clinical Research Studies
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Optimism, Hope, and Well-being
- Machine Learning in Healthcare
- Intensive Care Unit Cognitive Disorders
- Tea Polyphenols and Effects
- Artificial Intelligence in Healthcare and Education
Keio University
2021-2025
Keio University Hospital
2021-2024
Satou Hospital
2019-2023
National Institutes for Quantum Science and Technology
2022
University of Tsukuba
2015-2016
Bando Chemical Industries (Japan)
2012
Mount Sinai Beth Israel
2011-2012
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal total brain volumes among 8766 community-dwelling participants recruited from Japan Prospective Studies Collaboration for Aging Dementia 2016 2018. A Food Frequency Questionnaire was used to assess consumption, whereas magnetic resonance imaging performed lesions, volume, volume. Multivariable-adjusted analysis revealed significant correlations fewer higher no...
Plasma biomarkers have emerged as promising screening tools for Alzheimer's disease (AD) because of their potential to detect amyloid β (Aβ) accumulation in the brain. One such candidate is plasma Aβ42/40 ratio (Aβ42/40). Unlike previous research that used traditional immunoassay, recent studies measured using fully automated platforms reported results. However, its utility should be confirmed a broader patient population, focusing on early detection.We recruited 174 participants, including...
Abstract In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer’s disease (AD), has attracted much attention. However, evidence for relationship serum-hs-CRP dementia including AD are inconsistent. Therefore, relationships of serum high-sensitivity CRP (hs-CRP) with regions interest brain MRI were investigated. A total 11,957 community residents aged 65 years or older recruited in eight sites Japan (JPSC-AD Study). After applying exclusion...
With the widespread increase in elderly populations, quality of life and mental health old age are issues great interest. The human brain changes with age, aging process is biologically complex varies widely among individuals. In this cross-sectional study, to clarify effects health, as well common metabolic factors (e.g., diabetes) on healthy late life, we analyzed structural MRI findings examine relationship between predicted satisfaction, depressive symptoms, resilience, lifestyle-related...
<h3>Background and Objectives</h3> Epidemiologic evidence has shown that social isolation, a low frequency of contact with others, is associated the risk dementia late-life depressive symptoms. Therefore, we hypothesized may be involved in brain atrophy, symptoms play some role this relationship. We aimed to evaluate association between volumes various regions assess extent which mediate these relationships from large population-based multisite cohort study. <h3>Methods</h3> Dementia-free...
Live two-way video, easily accessible from home via smartphones and other devices, is becoming a new way of providing psychiatric treatment. However, lack evidence for real-world clinical setting effectiveness hampers its approval by medical insurance in some countries. Here, we conducted the first large-scale pragmatic, randomized controlled trial to determine long-term treatment multiple disorders video using which are currently primary means telecommunication.
Previous studies have evaluated the diagnostic effect of amyloid PET in selected research cohorts. However, these did not assess clinical impact combination and tau PETs. Our objective was to evaluate association 2 PETs with changes diagnosis, treatment, management a memory clinic cohort.All participants underwent [18F]florbetaben using [18F]PI-2620 or [18F]Florzolotau, which are potentially useful for diagnosis non-Alzheimer disease (AD) tauopathies. Dementia specialists determined pre-...
<title>Abstract</title> Background Plasma biomarkers offer a promising alternative to amyloid beta (Aβ) PET or cerebrospinal fluid (CSF) for diagnosing Alzheimer’s disease (AD). This cross-sectional study assessed the utility of multiple plasma in Japanese cohort, including healthy controls (HC), individuals on AD continuum, and those with non-AD cognitive impairment. Methods Participants were classified using Aβ imaging neuropsychological tests into HC, continuum (preclinical [preAD], mild...
The use of polygenic risk scores (PRS) for predicting disease in Japanese populations, particularly dementia and related phenotypes, remains markedly unexplored. aim this study was to bridge gap by developing a novel PRS model designed predict amyloid-β (Aβ) deposition utilizing positron emission tomography (PET) imaging data from cohort. Using the score-continuous shrinkage (PRS-CS) algorithm, we calculated based on significant single nucleotide polymorphisms (SNPs) associated with...
Background:While longitudinal studies have investigated the relationships between mild cognitive impairment (MCI) subtypes and dementia subtypes, results been contradictory. In addition, some research shows that depression accompanied by MCI might increase risk of Alzheimer's disease ( AD). Objective:The aim this study is to longitudinally investigate with special attention effect comorbid depressive symptoms in a Japanese rural community. Methods:Non-demented participants (n = 802)...
Abstract Previous studies have developed and explored magnetic resonance imaging (MRI)-based machine learning models for predicting Alzheimer’s disease (AD). However, limited research has focused on incorporating diverse patient populations. This study aimed to build a clinically useful prediction model amyloid-beta (Aβ) deposition using source-based morphometry, data-driven algorithm based independent component analyses. Additionally, we assessed how the predictive accuracies varied with...
Introduction The rapid spread of COVID-19 posed a global burden. Substantial number people died the disease in acute phase infection. In addition, significant proportion patients have been reported to suffer from post-acute symptoms, sequelae COVID-19, which may negatively influence quality daily living and/or socioeconomic circumstances patients. However, no previous study has comprehensively and objectively assessed life by using existing international scales. Further, evidence...
A number of studies have examined the effect a single supplement against Alzheimer's disease (AD) with conflicting results. Taking into account complex and multifactorial nature AD pathogenesis, multiple supplements may be more effective. P
Depressive and neurocognitive disorders are debilitating conditions that account for the leading causes of years lived with disability worldwide. However, there no biomarkers objective or easy-to-obtain in daily clinical practice, which leads to difficulties assessing treatment response developing new drugs. New technology allows quantification features clinicians perceive as reflective disorder severity, such facial expressions, phonic/speech information, body motion, activity, sleep. Major...
Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessing this issue. This study aimed examine the associations between urinary albumin-creatinine ratio (UACR) and eGFR levels WMLV in a community-dwelling older population of Japanese.Population-based cross-sectional study.A total 8,630...
Alzheimer's disease (AD) is the most common cause of dementia worldwide. In AD, abnormal tau accumulates within neurons brain, facilitated by extracellular β-amyloid deposition, leading to neurodegeneration, and eventually, cognitive impairment. As this process thought be irreversible, early identification in brain crucial for development new therapeutic interventions.18 F-PI-2620 one second-generation PET tracers with presumably less off-target binding than its predecessors. Although a few...
To reveal the clinical features and assess risk factors linked to brain fog its societal implications, including labor productivity, providing valuable insights for future care of individuals who have experienced coronavirus disease 2019 (COVID-19).
To establish simple screening tests to suspect Alzheimer's disease (AD) pathology, the clinical sign "head-turning sign" (HTS), which is a patient's behavior of turning their head towards partner seek assistance with questions posed by examiner during interview, and questionnaire for dementia named "Neucop-Q" were validated in participants diagnosed amyloid tau positron emission tomography (PET). We enrolled 155 patients: 47 cognitive normal, 36 mild impairment, 64 dementia, 8 psychiatric...
Few biomarkers can be used clinically to diagnose and assess the severity of depression. However, a decrease in activity sleep efficiency observed depressed patients, recent technological developments have made it possible measure these changes. In addition, physiological changes, such as heart rate variability, distinguish patients from normal persons; parameters improve diagnostic accuracy. The proposed research will explore construct machine learning models capable detecting depressive...
Background Studies have shown that decreased gait speed is associated with impaired cognitive function. However, whether this association equivalent across ages or genders in the older population remains unclear. Thus, we examined between mild impairment (MCI) and emphasising influence of age gender. Methods Overall, 8233 Japanese participants aged ≥65 years were enrolled cross‐sectional study 2016 2018. After stratification by gender group, participants' speeds divided into quintiles,...