A5009287865- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Organometallic Complex Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- Organoboron and organosilicon chemistry
- Synthetic Organic Chemistry Methods
- Carbon dioxide utilization in catalysis
- Cancer-related gene regulation
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Geological and Geochemical Analysis
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Surface Chemistry and Catalysis
- HER2/EGFR in Cancer Research
- Land Rights and Reforms
- Oxidative Organic Chemistry Reactions
- Cerebral Palsy and Movement Disorders
- Protein Structure and Dynamics
- Molecular spectroscopy and chirality
- Polymer Nanocomposites and Properties
- earthquake and tectonic studies
Eisai (Japan)
2018-2025
Kyoto University
2012-2024
National Rehabilitation Center for Persons with Disabilities
2021-2023
Japan Coast Guard Academy
2023
Center for Children
2021-2022
Nagoya University
2011-2020
Obihiro Kyokai Hospital
2018
Kurume University Hospital
2016
National Institute of Biomedical Innovation, Health and Nutrition
2012-2015
National Institute of Advanced Industrial Science and Technology
2010-2014
Lenvatinib is a multiple receptor tyrosine kinase inhibitor targeting mainly vascular endothelial growth factor (VEGF) and fibroblast (FGF) receptors. We investigated the immunomodulatory activities of lenvatinib in tumor microenvironment its mechanisms enhanced antitumor activity when combined with programmed cell death-1 (PD-1) blockade. Antitumor was examined immunodeficient immunocompetent mouse models. Single-cell analysis, flow cytometric immunohistochemistry were used to analyze...
Abstract Angiogenesis inhibitors such as lenvatinib and sorafenib, an immune checkpoint inhibitor ( ICI ), nivolumab, are used for anticancer therapies against advanced hepatocellular carcinoma HCC ). Combination treatments comprising angiogenesis plus s promising options improving clinical benefits in patients, trials ongoing. Here, we investigated the antitumor immunomodulatory activities of (a multiple receptor tyrosine kinase targeting vascular endothelial growth factor 1‐3, fibroblast...
Merging cooperative Si-H bond activation and electrophilic aromatic substitution paves the way for C-3-selective indole C-H functionalization under electronic not conventional steric control. The is heterolytically split by Ru-S of a coordinatively unsaturated cationic ruthenium(II) complex, forming sulfur-stabilized silicon electrophile. Wheland intermediate subsequent Friedel-Crafts-type process assumed to be deprotonated sulfur atom, no added base required. overall catalysis proceeds...
Abstract Chiral bis(oxazolinylphenyl)amines proved to be efficient auxiliary ligands for iron and cobalt catalysts with high activity asymmetric hydrosilylation of ketones conjugate enones.
High-dose ionizing radiation induces severe DNA damage in the epithelial stem cells small intestinal crypts and causes gastrointestinal syndrome (GIS). Although tumour suppressor p53 is a primary factor inducing death of crypt with damage, its essential role maintaining genome stability means inhibiting to prevent GIS not viable strategy. Here we show that innate immune receptor Toll-like 3 (TLR3) critical for pathogenesis GIS. Tlr3(-/-) mice substantial resistance owing significantly...
Just a little bit: The 1/FeCl2 complex was activated in the presence of Zn and exhibited catalytic activity for hydrosilane reduction ketones to give S-configured alcohol. In contrast, mixed-catalyst system 1 Fe(OAc)2 provides R enantiomer. This approach both enantiomers from single chiral source by addition small amount Zn. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...
Several transition-metal complexes that bind the bis(oxazolinyl)phenyl moiety as a tridentate ligand have been prepared to showcase their highly potent activities for asymmetric catalysis in conjugate reductions, reductive aldol reactions, direct reactions and hydrogenation reactions. Some of metals were also examined.
A patient with Graves' disease developed spontaneous hypoglycemia after treatment for 3 weeks methimazole. The hypoglycemic attacks lasted 4 days and disappeared spontaneously. Although the had never received exogenous insulin, significant insulin-binding antibodies were found in serum, a huge amount of immunoreactive insulin (23 100 to 35 280 μU/ml) was extracted from serum obtained during attacks. One year episode hypoglycemia, elevated still present patient. autoimmune concept might...
New chiral pincer iron complexes having bis(oxazolinyl)phenyl ligands have been synthesized by oxidative addition of Fe2(CO)9 to 2-bromo-substituted ligands. This complex can catalyze the asymmetric hydrosilylation simple aromatic ketones give corresponding alcohols.
We present an interpretable machine learning model for medical diagnosis called sparse high-order interaction with rejection option (SHIMR). A decision tree explains to a patient the long rule (i.e., conjunction of many intervals), while SHIMR employs weighted sum short rules. Using proteomics data 151 subjects in Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, is shown be as accurate other non-interpretable methods (Sensitivity, SN = 0.84 ± 0.1, Specificity, SP 0.69 0.15 and...
Abstract The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and the of multiple types cancer, its aberrant activation provides cancer cells with escape mechanisms from immune checkpoint inhibitors. E7386, an orally active selective inhibitor interaction between β-catenin CREB binding protein, which is part pathway, disrupts HEK293 adenomatous polyposis coli (APC)-mutated human gastric ECC10 cells. It also inhibited tumor growth xenograft model suppressed polyp...
Abstract Developmental dysplasia of the hip (DDH) is a cluster development disorders and one most common diseases in infants. Hip radiography convenient diagnostic tool for DDH, but its accuracy dependent on interpreter’s level experience. The aim this study was to develop deep learning model detecting DDH. Patients younger than 12 months who underwent between June 2009 November 2021 were selected. Using their images, transfer performed using “You Only Look Once” v5 (YOLOv5) single shot...
Propargylic alcohols were obtained with excellent enantioselectivities in the asymmetric direct alkynylation of aldehydes using 5 mol % chiral ruthenium complexes containing bis(oxazolinyl)phenyl ligand.
The transient titanium neopentylidyne, [(PNP)Ti≡C(t)Bu] (A; PNP(-)≡N[2-P(i)Pr2-4-methylphenyl]2(-)), dehydrogenates ethane to ethylene at room temperature over 24 h, by sequential 1,2-CH bond addition and β-hydrogen abstraction afford [(PNP)Ti(η(2)-H2C═CH2)(CH2(t)Bu)] (1). Intermediate A can also dehydrogenate propane propene, albeit not cleanly, as well linear volatile alkanes C4-C6 form isolable α-olefin complexes of the type, [(PNP)Ti(η(2)-H2C═CHR)(CH2(t)Bu)] (R = CH3 (2), CH2CH3 (3),...
Carbon–hydrogen bond activation of arenes by the pincer Ir(III) acetate complex (phebox)Ir(OAc)2(H2O) (1; phebox = bis(oxazolinyl)phenyl) proceeded at 100 °C to give corresponding aryl complexes (phebox)Ir(Ar)(OAc) in high yields. Reactions monosubstituted anisole, toluene, chlorobenzene, acetophenone, and nitrobenzene resulted formation meta- para-substituted Competitive experiments between two exhibited relative reaction rates order C6H5OMe > C6H5NO2 C6H5COMe C6H5Cl C6H5Me. The kinetic...
Abstract The bis(oxazolinyl)‐3,5‐dimethylphenylrhodium and ‐iridium complexes were synthesized in high yields by an efficient CH bond activation method with 4,6‐dimethyl‐1,3‐bis(oxazolinyl)benzene derivatives. catalytic activity of the was examined for asymmetric conjugate reduction ( E )‐ethyl 3‐phenylbut‐2‐enoate reductive aldol reaction tert ‐butyl acrylate benzaldehyde. It found that rhodium complex 3,5‐dmPhebox showed higher activity, whereas corresponding iridium proved to be less active.
Good to excellent enantioselectivities (up 99 % ee) of trans-cyclopropane derivatives were achieved in the cyclopropanation alkenes with tert-butyl α-diazoacetate by using 0.5 mol a mononuclear chiral ruthenium aqua complex containing bis(oxazolinyl)phenyl ligand, which was obtained via CH activation RuCl3⋅3 H2O presence Mg and cyclooctadiene (cod). Intramolecular reactions new Ru also proceed high yields enantioselectivities. Detailed facts importance specialist readers are published as...