A5101182918- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Heart Rate Variability and Autonomic Control
- Speech and Audio Processing
- Immunotherapy and Immune Responses
- Underwater Vehicles and Communication Systems
- Monoclonal and Polyclonal Antibodies Research
- Hearing Loss and Rehabilitation
- Underwater Acoustics Research
- Cancer Immunotherapy and Biomarkers
- Indoor and Outdoor Localization Technologies
- Immune Cell Function and Interaction
- Phonocardiography and Auscultation Techniques
- Human auditory perception and evaluation
- Freezing and Crystallization Processes
- Flow Measurement and Analysis
- Airway Management and Intubation Techniques
- ECG Monitoring and Analysis
- Respiratory Support and Mechanisms
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Obstructive Sleep Apnea Research
- Water Quality Monitoring Technologies
- Nanoplatforms for cancer theranostics
- Food Drying and Modeling
University of Tsukuba
2015-2025
Japan Research Institute
2024
Chiba University
2007-2011
Toyama Prefectural University
2003
Photoplethysmography (PPG) technology has been used to develop small, wearable, pulse rate sensors. These devices, consisting of infrared light-emitting diodes (LEDs) and photodetectors, offer a simple, reliable, low-cost means monitoring the noninvasively. Recent advances in optical have facilitated use high-intensity green LEDs for PPG, increasing adoption this measurement technique. In review, we briefly present history PPG recent developments wearable sensors with LEDs. The application...
Abstract Immune checkpoint blockade (ICB) efficiently reactivates effector T cells and induces antitumor efficacy. However, more than half of patients, particularly patients with the immunologically cold tumor microenvironment (TME), failed to experience clinical benefits, even in combination other drugs. To augment efficacy by ICB therapy, various attempts modify TME are under investigation. The activation innate immune cells, antigen-presenting (APCs), through pattern recognition...
In immune aplastic anemia (IAA), severe pancytopenia results from the immune-mediated destruction of hematopoietic stem cells. Several autoantibodies have been reported, but no clinically applicable autoantibody tests are available for IAA. We screened using a microarray containing >9000 proteins and validated findings in large international cohort IAA patients (n = 405) controls 815). identified novel that binds to C-terminal end cyclooxygenase 2 (COX-2, aCOX-2 Ab). total, 37% all adult...
Abstract This paper proposes a procedure for measuring transmitter–receiver (Tx–Rx) distance using acoustic communication signals to realize and positioning underwater with the same signal device. Specifically, we focus on an orthogonal division multiplexing, where pilot messages are placed in time–frequency domain. In this paper, show that measurements of both Tx–Rx speed available by utilizing signal. We conducted sea trial evaluated performance proposed method. During experiment, was...
This study examined position dependency in photoplethysmography (PPG). For transmitted-light PPG, a sensor is usually attached on fingertip and transmitted light monitored. Although simple to use, PPG cannot monitor vital signs during exercise daily activities because the attachment becomes disturbed. Reflected-light can be applied any part of body. However, differences cutaneous blood supply different regions have been reported, accuracy measurements vary among neighboring sites. cause...
Accurately measuring blood pressure (BP) is essential for maintaining physiological health, which commonly achieved using cuff-based sphygmomanometers. Several attempts have been made to develop cuffless To increase their accuracy and long-term variability, machine learning methods can be applied analyzing photoplethysmogram (PPG) signals. Here, we propose a method estimate the BP during exercise device. The estimation process involved preprocessing signals, feature extraction, techniques....
Noninvasive bone-conducted hearing aids require the consistent fitting of transducers for hearing. In this paper, a method estimating contact force and amount hair between person's skin sound transducer using electrical impedance is proposed. Experiments are conducted with human surface model consisting hair, skin, bone. The estimator implemented three-layered neural network. Ten measurements 70 conditions by changing from 0 to 5 N 169.6 mm3. With trained estimator, it possible estimate...
To evaluate the moisturizing function and other effects of royal jelly extract on skin. The applying an essence containing skin healthy Japanese males females were examined.Thirty-five men women who aware their dryness applied or placebo for 4 weeks using split-face method in a placebo-controlled, double-blind, parallel comparative study. stratum corneum water content, transepidermal evaporation, pigmentation, pores, redness evaluated.The content significantly increased by application to...
In this study, we evaluated a method of estimating the contact force bone-conducted sound transducer using human subjects. The was previously proposed and only with model. First, relationship between electrical impedance validated for 12 subjects from 10 Hz to 60 kHz. results showed that shows four peaks change all in same manner. A implemented three-layered neural network data estimation 90% error within ±0.43 N, which is possible. This result enables may support reproducible fitting transducer.
Measuring temperature distribution is an important technique in the fields of meteorology, agriculture, and architecture. The acoustic probe emits sound waves from a speaker measures time it takes for to reach microphone, enabling measurement average between microphone. Additionally, by placing multiple probes around area, becomes possible measure using fewer sensors compared point-type sensors. However, can have higher costs due requirement externally controllable setups or interfaces with...
Abstract Gut microbiota is associated with antitumor efficacy of immune checkpoint blockade therapies, yet the mechanism not largely understood. Here, we show that a novel bacterial strain Ruminococcaceae isolated from feces patients who respond to PD-1 (programmed cell death 1) efficiently primes/activates tumor-specific CD8+ T cells through effective stimulation/maturation CD103+ dendritic (DCs) during migration gut tumor microenvironment (TME). The administration this bacteria...
This paper proposes sparse channel estimation using basis pursuit denoising (BPDN) with a global optimum solution (GOS) for underwater acoustic (UWA) communication orthogonal signal division multiplexing (OSDM). To realize reliable UWA communication, we need to address delay and Doppler spreads by utilizing the nature of channel. BPDN recovers from observed signal, which consists original noise components. Conventional OSDM iterative-based suffers large computational complexity cannot fully...